Omneity® Pellets
All-In-One Vitamin & Mineral Pellet
Hormonal, metabolic and physiological effects of laparoscopic surgery using a detomidine-buprenorphine combination in standing horses.
Abstract: To assess the hormonal, metabolic and physiological effects of laparascopic surgery performed under a sedative analgesic combination of detomidine and buprenorphine in standing horses. Methods: Prospective study. Methods: Eight healthy adult Dutch Warmblood horses and five healthy adult ponies undergoing laparoscopy were studied. Five healthy adult horses not undergoing laparoscopy were used as a control group. Methods: The sedative effect of an initial detomidine and buprenorphine injection was maintained using a continuous infusion of detomidine alone. The heart and respiratory rate, arterial blood pH and arterial oxygen and carbon dioxide tensions were monitored, while blood samples were taken for the measurement of glucose, lactate, cortisol, insulin and nonesterified fatty acids (NEFA). The same variables were monitored in a control group of horses which were sedated, but which did not undergo surgery. At the end of the sedation period the effects of detomidine were antagonized using atipamezole. Results: The protocol provided suitable conditions for standing laparoscopy in horses. Laparoscopy induced obvious metabolic and endocrine responses which, with the exception of NEFA values, were not significantly different from changes found in the control group. While atipamezole did not produce detectable adverse effects, it is possible that anatagonism may not be essential. Conclusions: The technique described reliably produces adequate sedation and analgesia for laparoscopic procedures. The level of sedation/analgesia was controlled by decreasing or increasing the infusion rate. Antagonism of the effects of detomidine may not be necessary in all cases.
Copyright © 2003 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.
Publication Date: 2016-11-15 PubMed ID: 28404419DOI: 10.1046/j.1467-2995.2003.00097.xGoogle Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research paper investigates the impact of a detomidine-buprenorphine combination sedative on hormonal, metabolic, and physiological functions during laparoscopic surgery in standing horses.
Study Design and Methodology
The study had a prospective design and involved three groups
- Eight healthy adult Dutch Warmblood horses
- Five healthy adult ponies, all scheduled for laparoscopic surgery
- Five healthy adult horses for the control group – they were sedated but did not undergo surgery.
The sedative combo of detomidine and buprenorphine was administered as an initial injection. It was continuously maintained through a detomidine-only infusion.
Various physiological and biochemical factors were closely observed during the experiment. These included
A
Moreover, the blood samples were collected to measure the following metabolites:
- Glucose
- Lactate
- Cortisol
- Insulin
- Nonesterified fatty acids (NEFA).
At the end of the sedation period, the sedative’s effects were neutralized using the antagonist, atipamezole.
Outcomes
The proposed protocol, as concluded by the study, generated suitable conditions for laparoscopic surgery in stand-up horses. The surge in metabolic and endocrine responses witnessed was on par, excluding NEFA values, with the trends seen in the control group. While no substantial adverse effects were observed with atipamezole, it was suggested that the antagonist might not be essential in all situations.
Conclusions and Recommendations
The detomidine-buprenorphine combo reliably provided an optimal level of sedation and analgesia for laparoscopic procedures in horses. By tweaking the infusion rate, the sedation/analgesia level could be regulated. However, the need to neutralize detomidine’s effects may not be universally necessary. It indicates that it might depend on the specifics of individual cases and surgery procedures. Thus, the protocol may be adaptable for different situations.
Cite This Article
APA
Van Dijk P, Lankveld D, Rijkenhuizen A, Jonker FH.
(2016).
Hormonal, metabolic and physiological effects of laparoscopic surgery using a detomidine-buprenorphine combination in standing horses.
Vet Anaesth Analg, 30(2), 71-79.
https://doi.org/10.1046/j.1467-2995.2003.00097.x Publication
Researcher Affiliations
- Anaesthesiology and.
- Anaesthesiology and.
- Surgery, Department of Equine Sciences and.
- Department of Farm Animal Health, Veterinary Faculty, Utrecht University, Utrecht, The Netherlands.
Citations
This article has been cited 4 times.- Straticò P, Guerri G, Palozzo A, Varasano V, Petrizzi L. Current Use of Equine Laparoscopy in Urogenital Disorders: A Scoping Review of the Literature from 2000 to 2021. Vet Sci 2022 Jan 22;9(2).
- Haunhorst FR, Hopster K, Schmicke M, Bienert-Zeit A, Kästner S. Clinical effect of buprenorphine or butorphanol, in combination with detomidine and diazepam, on sedation and postoperative pain after cheek tooth extraction in horses. Can Vet J 2022 Jan;63(1):39-46.
- Beazley SG, Cosford K, Duke-Novakovski T. Cardiopulmonary effects of using carbon dioxide for laparoscopic surgery in cats. Can Vet J 2011 Sep;52(9):973-8.
- Cruz FS, Carregaro AB, Machado M, Antonow RR. Sedative and cardiopulmonary effects of buprenorphine and xylazine in horses. Can J Vet Res 2011 Jan;75(1):35-41.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
