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Clinical and vaccine immunology : CVI2006; 13(11); 1255-1266; doi: 10.1128/CVI.00150-06

Immunostimulatory effects of the anionic alkali mineral complex Barodon on equine lymphocytes.

Abstract: Previous studies have shown that the anionic alkali mineral complex BARODON has an immunoenhancing effect on pigs as an adjuvant and as a nonspecific immunostimulant. Likewise, the equine immune system has been defined with various monoclonal antibodies specific to equine leukocyte differentiation antigens to determine the possibility of enhancing equine resistance to respiratory diseases and promoting other immunostimulatory effects with the application of BARODON. Compared with the control group, after 3 weeks of treatment, BARODON-treated groups showed higher proportions of cells (P < 0.05) expressing major histocompatibility complex class II and CD2, CD4(+), CD4(+) CD25(+), CD8(+), and CD8(+) CD25(+) T lymphocytes, dendritic cells, and surface immunoglobulin M(+) B lymphocytes in peripheral blood, as well as enhanced cell proliferative responses with phytohemagglutinin and increased phagocytic activity against Streptococcus equi and Staphylococcus aureus strains with high antibiotic resistance, the bacteria frequently identified as etiologic agents of equine respiratory diseases at the Seoul Race Park in Seoul, Korea. This study shows that BARODON may act as an immunostimulator and can be an effective alternative to antimicrobial feed additives for nonspecific improvements in equine immune responses, particularly against respiratory diseases.
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Publication Date: 2006-08-30 PubMed ID: 16943344PubMed Central: PMC1656555DOI: 10.1128/CVI.00150-06Google Scholar: Lookup
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  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article explores how the anionic alkali mineral complex known as BARODON can boost the immune system of horses, particularly making them more resistant to respiratory illnesses. The study found that horses treated with BARODON had higher proportions of various kinds of beneficial immune cells in their blood and better immune responses.

Background

  • BARODON is an anionic alkali mineral complex that previous studies have suggested can enhance the immune system in pigs.
  • The study aims to explore the potential of BARODON as an immunostimulant in horses, to boost their resistance to respiratory diseases.

Methodology

  • The researchers used antibodies specific to equine leukocyte (white blood cell) differentiation antigens to determine the influence of BARODON on the horse’s immune system.
  • The treatment effects of BARODON were compared with a control group over a three-week period.

Findings

  • In the BARODON-treated groups, higher proportions of cells expressing major histocompatibility complex class II and various types of T lymphocytes, dendritic cells, and B lymphocytes were observed compared to the control groups.
  • The study also found that BARODON treatment led to an increase in cell proliferative responses with phytohemagglutinin and improved phagocytic activity against two bacterial strains – Streptococcus equi and Staphylococcus aureus. These strains are frequently identified as the causative agents of equine respiratory diseases, particularly in the Seoul Race Park, Korea.

Implications

  • The study suggests that BARODON could act as an immunostimulant and potentially provides an effective alternative to antimicrobial feed additives to enhance the immune responses of horses.
  • It specifically shows promise for mitigating respiratory diseases in the equine population.

Cite This Article

APA
Koo H, Ryu SH, Ahn HJ, Jung WK, Park YK, Kwon NH, Kim SH, Kim JM, Yoo BW, Choi SI, Davis WC, Park YH. (2006). Immunostimulatory effects of the anionic alkali mineral complex Barodon on equine lymphocytes. Clin Vaccine Immunol, 13(11), 1255-1266. https://doi.org/10.1128/CVI.00150-06

Publication

Clinical and vaccine immunology : CVI
ISSN: 1556-6811
NlmUniqueID: 101252125
Country: United States
Language: English
Volume: 13
Issue: 11
Pages: 1255-1266

Researcher Affiliations

Koo, Hyecheong
  • KRF Zoonotic Disease Priority Research Institute, College of Veterinary Medicine, Seoul National University, Sillim-dong, Gwanak-gu, Seoul, Republic of Korea.
Ryu, Seung-Ho
    Ahn, Hyung Jin
      Jung, Woo Kyung
        Park, Young Kyung
          Kwon, Nam Hoon
            Kim, So Hyun
              Kim, Jun Man
                Yoo, Byung Woo
                  Choi, Soo Il
                    Davis, William C
                      Park, Yong Ho

                        MeSH Terms

                        • Adjuvants, Immunologic / administration & dosage
                        • Alkalies / administration & dosage
                        • Alkalies / immunology
                        • Animal Feed
                        • Animals
                        • Anions / administration & dosage
                        • Anions / immunology
                        • Cell Proliferation
                        • Cells, Cultured
                        • Horses
                        • Lymphocyte Activation / immunology
                        • Lymphocyte Subsets / immunology
                        • Lymphocytes / cytology
                        • Lymphocytes / immunology
                        • Minerals / administration & dosage
                        • Minerals / immunology
                        • Solutions

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                        Citations

                        This article has been cited 5 times.
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