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Epidemics2022; 39; 100566; doi: 10.1016/j.epidem.2022.100566

Inference for a spatio-temporal model with partial spatial data: African horse sickness virus in Morocco.

Abstract: African horse sickness virus (AHSV) is a vector-borne virus spread by midges (Culicoides spp.). The virus causes African horse sickness (AHS) disease in some species of equid. AHS is endemic in parts of Africa, previously emerged in Europe and in 2020 caused outbreaks for the first time in parts of Eastern Asia. Here we analyse a unique historic dataset from the 1989-1991 emergence of AHS in Morocco in a naïve population of equids. Sequential Monte Carlo and Markov chain Monte Carlo techniques are used to estimate parameters for a spatial-temporal model using a transmission kernel. These parameters allow us to observe how the transmissibility of AHSV changes according to the distance between premises. We observe how the spatial specificity of the dataset giving the locations of premises on which any infected equids were reported affects parameter estimates. Estimations of transmissibility were similar at the scales of village (location to the nearest 1.3 km) and region (median area 99 km2), but not province (median area 3000 km2). This data-driven result could help inform decisions by policy makers on collecting data during future equine disease outbreaks, as well as policies for AHS control.
Publication Date: 2022-04-28 PubMed ID: 35576724DOI: 10.1016/j.epidem.2022.100566Google Scholar: Lookup
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  • Journal Article

Summary

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The research article is focused on a study of the African horse sickness virus (AHSV) in Morocco, analyzing a unique historical dataset from 1989-1991. The researchers use statistical techniques to estimate parameters for how the virus spreads in space and time, observing how these parameters change based on the distance between effective premises.

Objective of the Study

  • The main aim of the research is to investigate the transmissibility of African horse sickness virus (AHSv) in Morocco during the 1989-1991 period. The researchers have used spatial-temporal modeling, Sequential Monte Carlo and Markov chain Monte Carlo techniques to analyze how the spread of the virus was influenced by the distances between areas with reported infections.

Methodology

  • The researchers used Sequential Monte Carlo and Markov chain Monte Carlo techniques to construct a spatial-temporal model. This model is a statistical representation of the spread of AHSv over time and geographic location.
  • They gauged the transmissibility of AHSv according to the distance between premises (areas with reported infections). This method helps them understand how the virus spread in areas of varying distances apart.
  • The research focused on the 1989-1991 period when AHS was new in Morocco, hence, the population of equids (the family of mammals including horses, donkeys, and zebras) was naive or previously unexposed to this virus.

Results and Conclusions

  • The findings suggested similar transmissibility rates at the village level (location to the nearest 1.3 km) and region level (median area 99 km) but differed at the province level (median area 3000 km).
  • The research showed that the ‘spatial specificity’ of data, meaning the exactness of location data, had an effect on the estimation of transmissibility parameters.
  • These results can be used by policy makers to make informed decisions during future outbreaks of equine diseases. They can guide how data should be collected, and policies should be designed for AHS control.

Cite This Article

APA
Fairbanks EL, Baylis M, Daly JM, Tildesley MJ. (2022). Inference for a spatio-temporal model with partial spatial data: African horse sickness virus in Morocco. Epidemics, 39, 100566. https://doi.org/10.1016/j.epidem.2022.100566

Publication

ISSN: 1878-0067
NlmUniqueID: 101484711
Country: Netherlands
Language: English
Volume: 39
Pages: 100566

Researcher Affiliations

Fairbanks, Emma L
  • School of Veterinary Medicine and Science, University of Nottingham, Loughborough, LE12 5RD, UK. Electronic address: emma.fairbanks@swisstph.ch.
Baylis, Matthew
  • Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Leahurst Campus, Neston, Cheshire, CH64 7TE, UK.
Daly, Janet M
  • School of Veterinary Medicine and Science, University of Nottingham, Loughborough, LE12 5RD, UK.
Tildesley, Michael J
  • The Zeeman Institute for Systems Biology & Infectious Disease Epidemiology Research, School of Life Sciences and Mathematics Institute, University of Warwick, Coventry, CV4 7AL, UK.

MeSH Terms

  • African Horse Sickness / epidemiology
  • African Horse Sickness / prevention & control
  • African Horse Sickness Virus
  • Animals
  • Ceratopogonidae
  • Disease Outbreaks / veterinary
  • Horses
  • Morocco / epidemiology