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Journal of veterinary internal medicine2021; 35(3); 1582-1588; doi: 10.1111/jvim.16079

Influence of endocrine disease on l-lactate concentrations in blood of ponies.

Abstract: Blood l-lactate concentrations are higher in people with developing or established diabetes mellitus and insulin resistance. Objective: To investigate whether blood l-lactate concentrations are positively correlated with measures of insulin dysregulation (ID) or increased autumnal ACTH concentrations in ponies. Methods: Systemically healthy client-owned ponies (n = 101). Methods: Prospective case-control study. Blood samples were obtained from 101 clinically healthy ponies. Breed, weight, height, and subjective and objective measures of body condition were recorded. Blood l-lactate, glucose, triglyceride, total adiponectin, and ACTH concentrations were measured and an oral sugar test (OST) was carried out. Correlations between blood l-lactate and variables of endocrine health were determined. Results: Using a seasonal cutoff point of ACTH concentrations ≥47 pg/mL, 55 ponies had increased autumnal ACTH concentrations and 45 did not. Using a basal insulin concentration of >50 μiU/mL, 42 ponies were diagnosed with ID and 58 were not. Using a 60 minutes after OST cutoff point of >45 μiU/mL, 57 ponies had ID and 37 did not. Blood l-lactate concentrations were significantly lower in obese (average body condition score ≥ 7/9) compared to nonobese ponies (0.6 mmol/L; range, 0.0-1.9 mmol/L vs 0.8 mmol/L; range, 0.3-2.7 mmol/L; P = .01). No other significant correlations were detected. No differences were detected between ponies with and without increased autumnal ACTH concentrations (0.7 mmol/L; range, 0.0-2.7 mmol/L vs 0.7 mmol/L; range, 0.3-1.8 mmol/L; P = .84) and with and without ID (0.7 mmol/L; range, 0.3-2.7 mmol/L vs 0.8 mmol/L; range, 0.0-1.6 mmol/L; P = .63). Conclusions: Results do not support an effect of endocrine status on l-lactate concentrations in blood of ponies.
© 2021 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.
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Publication Date: 2021-05-27 PubMed ID: 34043845PubMed Central: PMC8162605DOI: 10.1111/jvim.16079Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research investigates if there is a correlation between higher levels of l-lactate in pony blood and instances of insulin dysregulation or increased autumnal ACTH concentrations. The study found no significant effect of endocrine status on l-lactate concentrations in pony blood.

Objective and Methodology

  • The primary aim of this research was to examine whether blood l-lactate concentrations are positively linked with indications of insulin dysregulation (ID) or increased rates of ACTH (a hormone) during the autumn season in ponies.
  • The study involved a case-control methodology performed on 101 systemically healthy ponies.
  • To gather quantitative data, various tests were conducted including the measurement of blood l-lactate, glucose, triglyceride, total adiponectin, and ACTH concentrations. An oral sugar test (OST) was also performed.
  • The breed, weight, height, and both subjective and objective assessments of the ponies’ body conditions were also noted to provide contextual data.

Results

  • The results were divided based on ACTH concentrations, insulin levels, and OST results. According to predetermined thresholds, 55 ponies had increased ACTH concentrations, 42 showed insulin dysregulation, and 57 had abnormal OST results.
  • Surprisingly, obese ponies (those with a body condition score ≥ 7/9) had lower blood l-lactate concentrations compared to the non-obese sample.
  • No other significant correlations were found between blood l-lactate concentrations and the recorded endocrine health variables.
  • There was no difference in l-lactate concentrations between ponies with and without increased autumnal ACTH concentrations or insulin dysregulation.

Conclusions

  • Based on the findings of this research, it can be concluded that endocrine status does not influence l-lactate concentrations in the blood of ponies.
  • These results contradict earlier hypotheses and imply that other factors might be at play concerning l-lactate concentration changes. Further, the findings may also suggest potential differences in the metabolic response to insulin dysregulation and ACTH changes between humans and ponies.

Cite This Article

APA
Dunkel B, Knowles EJ, Chang YM, Menzies-Gow NJ. (2021). Influence of endocrine disease on l-lactate concentrations in blood of ponies. J Vet Intern Med, 35(3), 1582-1588. https://doi.org/10.1111/jvim.16079

Publication

Journal of veterinary internal medicine
ISSN: 1939-1676
NlmUniqueID: 8708660
Country: United States
Language: English
Volume: 35
Issue: 3
Pages: 1582-1588

Researcher Affiliations

Dunkel, Bettina
  • Department of Clinical Science and Services, The Royal Veterinary College, North Mymms, United Kingdom.
Knowles, Edward J
  • Department of Clinical Science and Services, The Royal Veterinary College, North Mymms, United Kingdom.
Chang, Yu-Mei
  • Research Support Office, The Royal Veterinary College, North Mymms, United Kingdom.
Menzies-Gow, Nicola J
  • Department of Clinical Science and Services, The Royal Veterinary College, North Mymms, United Kingdom.

MeSH Terms

  • Animals
  • Blood Glucose
  • Case-Control Studies
  • Endocrine System Diseases / veterinary
  • Horse Diseases
  • Horses
  • Insulin
  • Lactic Acid
  • Prospective Studies

Conflict of Interest Statement

Authors declare no conflict of interest.

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