Influence of exogenous progesterone on early embryonic development in the mare.
Abstract: The influence of exogenous progesterone on the development of equine oviductal embryos was determined based upon the recovery of Day-7 uterine blastocysts from treated mares (n=13) that were given 450 mg progesterone daily between Days 0 and 6 and from untreated control mares (n=13). Daily administration of 450 mg progesterone in oil significantly (P<0.02) increased serum progesterone concentrations in the treated mares. There was no significant difference in the recovery rate of Day-7 embryos between treated and control mares (8/13 versus 6/13, respectively). Embryonic development, assessed by morphologic evaluation, embryo diameter, and number of cell nuclei was not significantly different for embryos from treated and from control mares. The results of this study indicate that administration of progesterone beginning on the day of ovulation does not affect the embryo recovery rate or embryonic development, based on evaluation of uterine blastocysts recovered at Day 7 after ovulation.
Publication Date: 1992-12-01 PubMed ID: 16727203DOI: 10.1016/0093-691x(92)90119-cGoogle Scholar: Lookup
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Summary
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The research explores whether the addition of external progesterone affects early embryonic development in horses, concluding that there was no significant effect on embryo recovery rate or development.
Research Methodology
- The study examined the role of added progesterone on the development of horse embryos in the oviduct (a part of a female horse’s reproductive tract).
- The test group consisted of 13 mares that were given a daily dose of 450 mg progesterone from the day of ovulation to six days after.
- Another set of 13 mares, which did not receive progesterone, were used as a control group.
Key Findings
- The researchers found that the use of external progesterone boosted progesterone levels in the blood of the treated group, indicating the substance remained active in the body.
- However, despite the increase of progesterone levels in the treated group, it did not significantly affect the chances of retrieving a Day-7 embryo – an early-stage embryo that grows in the uterus seven days post-ovulation – from either group.
- The study also showed no significant differences in embryonic development in terms of morphology, diameter, and the number of cell nuclei between embryos from the treated and untreated mares.
Study Conclusion
- The results of the study revealed that giving progesterone to the mare starting on the day of ovulation had no notable impact on the embryo recovery rate or the progression of embryonic development.
- The embryos’ morphology, size, and cellular structure remained alike irrespective of whether the mare received additional progesterone.
Implications of the Study
- The research suggests that progesterone supplement does not interfere with early embryonic development in mares, providing a basis for further exploration of the influence of different hormones on equine reproduction.
- This study could also have practical implications on vet practices and breeders who are considering the use of hormone supplementation in horse breeding programs.
Cite This Article
APA
Ball BA, Miller PG, Daels PF.
(1992).
Influence of exogenous progesterone on early embryonic development in the mare.
Theriogenology, 38(6), 1055-1063.
https://doi.org/10.1016/0093-691x(92)90119-c Publication
Researcher Affiliations
- Department of Clinical Sciences, Cornell University, Ithaca, New York 14853, USA.
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