Inheritance of an abnormal haemoglobin haplotype in horses and its possible influence on blood values.
Abstract: In a breeding experiment a stallion of the native Norwegian Trotter breed with an abnormal Hb haplotype (N) and with the Hb type BI/N, sired 6 offspring. The abnormal haplotype controls one α-chain only, having lysine at position 60 and phenylalanine at position 24. Three of the offspring received the N haplotype from the sire and the BII haplotype from the dam, whereas the other 3 offspring received BI from the sire. The BII/N horses have two Hb components after alkaline electrophoresis or isoelectric focusing with the ratio between the fast and the slow band (anodal, cathodal) being approximately 30:70. Blood value determinations did not give any definite conclusions as regards differences between horses with the abnormal Hb type and normal horses of similar age within the same breed. En Norsk Traver hingst med en unormal Hb haplotype (N) og med Hb type BI/N fikk i et avlsfors0k seks avkom. Den unormale haplotype kontrollerer en a-kjede. Denne har lysin i posisjon nr. 60 og fenylalanin i posisjon nr. 24. Tre avkom fikk N haplotypen fra hingsten og BII fra hoppen, mens de tre andre avkom fikk BI fra hingsten. Hestene med Hb typen BII/N viser to Hb komponenter etter elektroforese i alkalisk miljø eller isoelektrisk fokusering. Forholdet mellom den hurtigste og den saktere komponent (anode—katode) er omtrent 30:70. Bestemmelser av blodverdier viste ingen sikre for-skjeller mellom de hester som har den unormale Hb type og normale hester av tilsvarende alder og rase.
Publication Date: 1983-01-01 PubMed ID: 6675451PubMed Central: PMC8291246DOI: 10.1186/BF03546712Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
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The study explores the inheritance pattern of an unusual hemoglobin (Hb) haplotype (genetic variation) in horses, specifically from a native Norwegian Trotter breed, and its potential impact on blood values. The researchers examined offspring from a stallion carrying this abnormal Hb to study its transmission and effect.
Experiment Setup
- The researchers carried out a breeding experiment involving a Norwegian Trotter stallion with an abnormal Hb haplotype labeled as N and with Hb type BI/N. This stallion fathered six offspring in the experiment.
Abnormal Haplotype Characteristics
- The abnormal N haplotype manages only one alpha chain (an important element of the molecule responsible for binding oxygen) which features the amino acids lysine at position 60 and phenylalanine at position 24. This composition is unusual compared to the normal hemoglobin structure of horses.
Haplotype Inheritance Among Offspring
- Three offspring inherited the N haplotype from the sire (father) and the BII haplotype from the dam (mother). The remaining three offspring received the BI haplotype from the sire.
Characteristics of Horses with BII/N Hb Type
- Horses having the Hb type BII/N demonstrate two Hb components when subjected to alkaline electrophoresis or isoelectric focusing, two methods used to analyze and separate proteins.
- The ratio between the fast (anodal) and the slow band (cathodal) is approximately 30:70. This suggests an atypical distribution of hemoglobin types in the blood of these horses.
Blood Value Comparison
- The study does not provide clear evidence of any significant differences in blood values between horses carrying the abnormal Hb type and normal horses of the same breed and age. Thus, the presence of the abnormal Hb may not have a prominent impact on the overall health or blood properties of the horse.
Cite This Article
APA
Braend M, Clegg JB, Storset A.
(1983).
Inheritance of an abnormal haemoglobin haplotype in horses and its possible influence on blood values.
Acta Vet Scand, 24(4), 384-391.
https://doi.org/10.1186/BF03546712 Publication
Researcher Affiliations
MeSH Terms
- Animals
- Erythrocyte Indices / veterinary
- Female
- Hematocrit / veterinary
- Hemoglobins, Abnormal / genetics
- Horses / blood
- Horses / genetics
- Male
References
This article includes 10 references
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- Braend M, J B Clegg. Irregular transmission of horse hemoglobin α-chain genes (Abstract). Genetics 1973, 74, June Suppl. no 2, part 2, p. 30.
- Clegg JB. Horse haemoglobin polymorphism: evidence for two linked non-allelic alpha-chain genes.. Proc R Soc Lond B Biol Sci 1970 Nov 3;176(1043):235-46.
- Clegg JB. Horse hemoglobin polymorphism.. Ann N Y Acad Sci 1974 Nov 29;241(0):61-9.
- Kilmartin JV, Clegg JB. Amino-acid replacements in horse haemoglobin.. Nature 1967 Jan 21;213(5073):269-71.
- Lie H. Serum types of the Nordland horse and the Norwegian trotter.. Nord Vet Med 1973 Feb;25(2):83-7.
- Paulsson S, B Åberg. Kliniskt-kemiska och hematologiska normal-värden. (Clinical-chemical and hematological normal values). .
- Svensk Vet. Tidn. 1965, 17, 462–476.
- Persson S. On blood volume and working capacity in horses. Studies of methodology and physiological and pathological variations.. Acta Vet Scand 1967;:Suppl 19:9-189.
- Schalm OW, N C Jain, E J Carrol. Veterinary Hematology. 3rd ed. Lea & Febiger, Philadelphia 1975, 807 pp..
Citations
This article has been cited 1 times.- Clegg JB, Goodbourn SE, Braend M. Genetic organization of the polymorphic equine alpha globin locus and sequence of the BII alpha 1 gene. Nucleic Acids Res 1984 Oct 25;12(20):7847-58.
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