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Iron-related markers of inflammation in horses with colic.
Abstract: The aim of the study was to compare and correlate levels of ferritin, transferrin, iron and APPs in healthy horses and those surgically treated for strangulating colic. On admission, measurements of inflammatory markers related to iron and total protein, fibrinogen, albumin, haptoglobin and ceruloplasmin were made. The study comprised 22 horses, divided into a control group (CG) of healthy horses (n = 10) and horses with surgically treated acute abdomen (n = 12), obstruction group (OG). The OG was subdivided according to the affected intestinal segment (small vs. large) and according to outcome (survivors vs. non survivors). The OG had higher haptoglobin (34.8±14.2 mg/dL vs 20.8±7.21 mg/dL) and transferrin (487±161 mg/dL vs 369±71.4 mg/dL) values and lower iron (96.9±65 µg/dL vs 218±105 µg/dL) values than the CG. The OG horses with large intestine obstruction had lower values of transferrin (374.6±130 mg/dL) than horses with small intestinal obstruction (598.6±98.9 mg/dL). There was no difference in outcome between horses with large and small intestinal obstruction. Ferritin levels were moderately correlated with total protein (r = 0.594; P = 0.042) and albumin (r = 0.584; P = 0.046) in OG. In the multivariate exploratory analysis, fibrinogen levels were higher in animals that did not survive. In conclusion, haptoglobin, transferrin and iron were useful inflammatory markers for colic in horses. The correlation of ferritin with other APPs shows a possible role of ferritin as an APP in horses. Fibrinogen levels are higher in horses with greater risk of death from strangulating obstructions.
Copyright © 2024 Elsevier Inc. All rights reserved.
Publication Date: 2024-01-28 PubMed ID: 38286193DOI: 10.1016/j.jevs.2024.105010Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
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The research investigates the correlation and comparison of ferritin, transferrin, iron, and acute phase proteins (APPs) levels in healthy horses and those undergoing surgical treatment for strangulating colic. It finds that haptoglobin, transferrin, and iron are effective inflammatory markers for colic in horses, and ferritin could also potentially play a role. Higher levels of fibrinogen were discovered in horses at a higher risk of strangulating obstructions death.
Research Method and Participants
- The research involved a total of 22 horses which were split into two groups. The control group consisted of 10 healthy horses, while the other group comprised 12 horses treated for acute abdomen through surgery and were collectively referred to as the obstruction group (OG).
- On admission, several health markers relating to inflammation and iron, including total protein, fibrinogen, albumin, haptoglobin, and ceruloplasmin, were measured.
- The OG was further divided according to the section of the intestine affected by the obstruction (small vs. large), and whether the horses survived or not after the treatment.
Findings and Results
- The research found that the OG had higher levels of haptoglobin and transferrin but lower levels of iron compared to the control group.
- For the OG, horses with a large intestine blockade manifested lesser transferrin values compared to those with a small intestine blockade.
- No difference was observed in the outcome between horses afflicted with large or small intestinal obstructions.
- A moderate correlation between ferritin levels and total protein and albumin was noted in the OG. These correlations might suggest a possible role of ferritin as an APP in horses.
- The research also found that horses, which unfortunately did not survive, had higher fibrinogen levels.
Conclusion and Significance
- Based on the results, transferrin, haptoglobin, and iron were identified as reliable inflammatory markers for colic in horses.
- Ferritin’s correlation with other APPs points to its potential role as an APP in horses.
- Further, elevated fibrinogen levels were linked to a greater risk of mortality in horses due to strangulating obstructions, implying that fibrinogen levels could be a crucial determinant in assessing risks.
Cite This Article
APA
Canola PA, Salles RF, Daneze ER, Sobreira MFR, Oliveira BE, Favero ML, Antonioli ML.
(2024).
Iron-related markers of inflammation in horses with colic.
J Equine Vet Sci, 134, 105010.
https://doi.org/10.1016/j.jevs.2024.105010 Publication
Researcher Affiliations
- Department of Veterinary Medicine and Surgery, Su00e3o Paulo State University (Unesp), School of Agricultural and Veterinarian Sciences, Via de Acesso Prof. Paulo Donato Castellane, Jaboticabal, Su00e3o Paulo 14884-900, Brazil. Electronic address: paulo.canola@unesp.br.
- Su00e3o Paulo State University (Unesp), School of Agricultural and Veterinarian Sciences, Jaboticabal, Su00e3o Paulo, Brazil.
- Su00e3o Paulo State University (Unesp), School of Agricultural and Veterinarian Sciences, Jaboticabal, Su00e3o Paulo, Brazil.
- Centro Universitu00e1rio Moura Lacerda, Ribeiru00e3o Preto, Su00e3o Paulo, Brazil.
- Su00e3o Paulo State University (Unesp), School of Agricultural and Veterinarian Sciences, Jaboticabal, Su00e3o Paulo, Brazil.
- Su00e3o Paulo State University (Unesp), School of Agricultural and Veterinarian Sciences, Jaboticabal, Su00e3o Paulo, Brazil.
- Su00e3o Paulo State University (Unesp), School of Agricultural and Veterinarian Sciences, Jaboticabal, Su00e3o Paulo, Brazil.
Conflict of Interest Statement
Declaration of competing interest None of the authors has any financial or personal relationships that could inappropriately influence or bias the content of the paper.
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