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Home / Equine Research Bank / J Virol / Isolation and characterization of an equine foamy virus.
Journal of virology2001; 74(9); 4064-4073; doi: 10.1128/jvi.74.9.4064-4073.2000

Isolation and characterization of an equine foamy virus.

Abstract: Foamy viruses (FVs) are complex retroviruses which have been isolated from different animal species including nonhuman primates, cattle, and cats. Here, we report the isolation and characterization of a new FV isolated from blood samples of horses. Similar to other FVs, the equine foamy virus (EFV) exhibits a highly characteristic ultrastructure and induces syncytium formation and subsequent cell lysis on a large number of cell lines. Molecular cloning of EFV reveals that the general organization is that of other known FVs, whereas sequence similarity with its bovine FV counterpart is only 40%. Interestingly, EFV buds exclusively from the plasma membrane and not from the endoplasmic reticulum (ER), as previously shown for other FVs. The absence of the ER retrieval dilysine motif in EFV Env is likely responsible for this unexpected sorting pathway.
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Publication Date: 2001-02-07 PubMed ID: 10756018PubMed Central: PMC111920DOI: 10.1128/jvi.74.9.4064-4073.2000Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article discusses the discovery and analysis of a new type of Foamy Virus (FV), found in horses, that presents different characteristics compared to other known FVs in animals.

Introduction

  • The paper introduces Foamy Viruses (FVs) as complex retroviruses. These viruses have previously been found in a variety of animal species including but not limited to nonhuman primates, cattle, and cats.
  • The researchers report the isolation of an FV from the blood samples of horses, naming it Equine Foamy Virus (EFV).

Characteristic Features

  • Just like various other FVs, this EFV showcases a highly unique ultrastructure and elicits the formation of syncytium – a multinucleated cell that results from the fusion of several cells, leading to eventual cell lysis, or cell death, in numerous cell lines.
  • The paper explains that molecular cloning, which is the process of creating identical copies of DNA fragments, of EFV have shown that the general composition and pattern of this virus aligns with previously known FVs.

Distinctive Traits

  • One key finding is that the sequence similarity between EFV and its Bovine FV counterpart is only 40%, suggesting significant differences in their genetic components.
  • Moreover, a significant finding from the research was that EFV buds solely from the plasma membrane of the cell, rather than the endoplasmic reticulum. This is a departure from what has been previously observed for other FVs, making the EFV’s maturation process unique.
  • The paper also suggests that the lack of the ER retrieval dilysine motif, a specific sequence of amino acids, in the EFV envelope protein, might be responsible for this unique viral maturation pathway.

Conclusion

  • In short, the discovery of the Equine Foamy Virus provides new insights into the diversity and genetic makeup of Foamy Viruses. The unique properties and patterns observed in EFV indicate the vast extent of variation in the behaviors of these types of viruses, which has implications for understanding virus-host interactions and potentially developing antiviral strategies.

Cite This Article

APA
Tobaly-Tapiero J, Bittoun P, Neves M, Guillemin MC, Lecellier CH, Puvion-Dutilleul F, Gicquel B, Zientara S, Giron ML, de Thé H, Saïb A. (2001). Isolation and characterization of an equine foamy virus. J Virol, 74(9), 4064-4073. https://doi.org/10.1128/jvi.74.9.4064-4073.2000

Publication

Journal of virology
ISSN: 0022-538X
NlmUniqueID: 0113724
Country: United States
Language: English
Volume: 74
Issue: 9
Pages: 4064-4073

Researcher Affiliations

Tobaly-Tapiero, J
  • CNRS UPR9051, Université Paris 7, Hôpital Saint-Louis, 75475 Paris Cedex 10, France.
Bittoun, P
    Neves, M
      Guillemin, M C
        Lecellier, C H
          Puvion-Dutilleul, F
            Gicquel, B
              Zientara, S
                Giron, M L
                  de Thé, H
                    Saïb, A

                      MeSH Terms

                      • Amino Acid Sequence
                      • Animals
                      • Antibodies, Viral / blood
                      • Antibodies, Viral / immunology
                      • Antigens, Viral / immunology
                      • Base Sequence
                      • Blotting, Southern
                      • COS Cells
                      • Cats
                      • Cattle
                      • Cloning, Molecular
                      • Cricetinae
                      • DNA, Viral / analysis
                      • Genes, env
                      • Genes, gag
                      • Genes, pol
                      • Horse Diseases / blood
                      • Horse Diseases / immunology
                      • Horse Diseases / virology
                      • Horses
                      • Humans
                      • Molecular Sequence Data
                      • Proviruses / genetics
                      • Rabbits
                      • Retroviridae Infections / blood
                      • Retroviridae Infections / immunology
                      • Retroviridae Infections / veterinary
                      • Retroviridae Infections / virology
                      • Sequence Analysis, DNA
                      • Sequence Homology, Amino Acid
                      • Spumavirus / genetics
                      • Spumavirus / immunology
                      • Spumavirus / isolation & purification
                      • Terminal Repeat Sequences
                      • Transcriptional Activation
                      • Tumor Cells, Cultured

                      References

                      This article includes 28 references
                      1. Bock M, Heinkelein M, Lindemann D, Rethwilm A. Cells expressing the human foamy virus (HFV) accessory Bet protein are resistant to productive HFV superinfection.. Virology 1998 Oct 10;250(1):194-204.
                        pubmed: 9770433doi: 10.1006/viro.1998.9362google scholar: lookup
                      2. De Celis J, Tobaly-Tapiero J, Hampe A, Emanoil-Ravier R. Structure and function of the long terminal repeat of the chimpanzee foamy virus isolates (SFV-6).. Arch Virol 1994;138(3-4):345-55.
                        pubmed: 7998839doi: 10.1007/BF01379137google scholar: lookup
                      3. Giron ML, Colas S, Wybier J, Rozain F, Emanoil-Ravier R. Expression and maturation of human foamy virus Gag precursor polypeptides.. J Virol 1997 Feb;71(2):1635-9.
                        pmc: PMC191222pubmed: 8995691doi: 10.1128/JVI.71.2.1635-1639.1997google scholar: lookup
                      4. Giron ML, de Thé H, Saïb A. An evolutionarily conserved splice generates a secreted env-Bet fusion protein during human foamy virus infection.. J Virol 1998 Jun;72(6):4906-10.
                        pmc: PMC110047pubmed: 9573257doi: 10.1128/JVI.72.6.4906-4910.1998google scholar: lookup
                      5. Goepfert PA, Shaw K, Wang G, Bansal A, Edwards BH, Mulligan MJ. An endoplasmic reticulum retrieval signal partitions human foamy virus maturation to intracytoplasmic membranes.. J Virol 1999 Sep;73(9):7210-7.
                        pmc: PMC104245pubmed: 10438808doi: 10.1128/JVI.73.9.7210-7217.1999google scholar: lookup
                      6. Goepfert PA, Shaw KL, Ritter GD Jr, Mulligan MJ. A sorting motif localizes the foamy virus glycoprotein to the endoplasmic reticulum.. J Virol 1997 Jan;71(1):778-84.
                        pmc: PMC191117pubmed: 8985416doi: 10.1128/JVI.71.1.778-784.1997google scholar: lookup
                      7. Goepfert PA, Wang G, Mulligan MJ. Identification of an ER retrieval signal in a retroviral glycoprotein.. Cell 1995 Aug 25;82(4):543-4.
                        pmc: PMC7172326pubmed: 7664333doi: 10.1016/0092-8674(95)90026-8google scholar: lookup
                      8. Hill CL, Bieniasz PD, McClure MO. Properties of human foamy virus relevant to its development as a vector for gene therapy.. J Gen Virol 1999 Aug;80 ( Pt 8):2003-2009.
                        pubmed: 10466797doi: 10.1099/0022-1317-80-8-2003google scholar: lookup
                      9. Kupiec JJ, Sonigo P. Reverse transcriptase jumps and gaps.. J Gen Virol 1996 Sep;77 ( Pt 9):1987-91.
                        pubmed: 8810994doi: 10.1099/0022-1317-77-9-1987google scholar: lookup
                      10. Kupiec JJ, Tobaly-Tapiero J, Canivet M, Santillana-Hayat M, Flügel RM, Périès J, Emanoil-Ravier R. Evidence for a gapped linear duplex DNA intermediate in the replicative cycle of human and simian spumaviruses.. Nucleic Acids Res 1988 Oct 25;16(20):9557-65.
                        pmc: PMC338763pubmed: 2847117doi: 10.1093/nar/16.20.9557google scholar: lookup
                      11. Lindemann D, Rethwilm A. Characterization of a human foamy virus 170-kilodalton Env-Bet fusion protein generated by alternative splicing.. J Virol 1998 May;72(5):4088-94.
                        pmc: PMC109638pubmed: 9557698doi: 10.1128/JVI.72.5.4088-4094.1998google scholar: lookup
                      12. Linial ML. Foamy viruses are unconventional retroviruses.. J Virol 1999 Mar;73(3):1747-55.
                        pmc: PMC104413pubmed: 9971751doi: 10.1128/JVI.73.3.1747-1755.1999google scholar: lookup
                      13. Löchelt M, Flügel RM, Aboud M. The human foamy virus internal promoter directs the expression of the functional Bel 1 transactivator and Bet protein early after infection.. J Virol 1994 Feb;68(2):638-45.
                        pmc: PMC236497pubmed: 8289367doi: 10.1128/JVI.68.2.638-645.1994google scholar: lookup
                      14. Löchelt M, Muranyi W, Flügel RM. Human foamy virus genome possesses an internal, Bel-1-dependent and functional promoter.. Proc Natl Acad Sci U S A 1993 Aug 1;90(15):7317-21.
                        pmc: PMC47128pubmed: 8394017doi: 10.1073/pnas.90.15.7317google scholar: lookup
                      15. Löchelt M, Yu SF, Linial ML, Flügel RM. The human foamy virus internal promoter is required for efficient gene expression and infectivity.. Virology 1995 Jan 10;206(1):601-10.
                        pubmed: 7831816doi: 10.1016/s0042-6822(95)80077-8google scholar: lookup
                      16. Pfrepper KI, Löchelt M, Rackwitz HR, Schnölzer M, Heid H, Flügel RM. Molecular characterization of proteolytic processing of the Gag proteins of human spumavirus.. J Virol 1999 Sep;73(9):7907-11.
                        pmc: PMC104327pubmed: 10438890doi: 10.1128/JVI.73.9.7907-7911.1999google scholar: lookup
                      17. Pfrepper KI, Löchelt M, Schnölzer M, Flügel RM. Expression and molecular characterization of an enzymatically active recombinant human spumaretrovirus protease.. Biochem Biophys Res Commun 1997 Aug 28;237(3):548-53.
                        pubmed: 9299401doi: 10.1006/bbrc.1997.7187google scholar: lookup
                      18. Pfrepper KI, Rackwitz HR, Schnölzer M, Heid H, Löchelt M, Flügel RM. Molecular characterization of proteolytic processing of the Pol proteins of human foamy virus reveals novel features of the viral protease.. J Virol 1998 Sep;72(9):7648-52.
                        pmc: PMC110030pubmed: 9696869doi: 10.1128/JVI.72.9.7648-7652.1998google scholar: lookup
                      19. Saïb A, Koken MH, van der Spek P, Périès J, de Thé H. Involvement of a spliced and defective human foamy virus in the establishment of chronic infection.. J Virol 1995 Sep;69(9):5261-8.
                        pmc: PMC189359pubmed: 7636968doi: 10.1128/JVI.69.9.5261-5268.1995google scholar: lookup
                      20. Saïb A, Périès J, de Thé H. Recent insights into the biology of the human foamy virus.. Trends Microbiol 1995 May;3(5):173-8.
                        pubmed: 7627455doi: 10.1016/s0966-842x(00)88916-7google scholar: lookup
                      21. Schliephake AW, Rethwilm A. Nuclear localization of foamy virus Gag precursor protein.. J Virol 1994 Aug;68(8):4946-54.
                        pmc: PMC236435pubmed: 8035493doi: 10.1128/JVI.68.8.4946-4954.1994google scholar: lookup
                      22. Schmidt M, Herchenröder O, Heeney J, Rethwilm A. Long terminal repeat U3 length polymorphism of human foamy virus.. Virology 1997 Apr 14;230(2):167-78.
                        pubmed: 9143272doi: 10.1006/viro.1997.8463google scholar: lookup
                      23. Tobaly-Tapiero J, Kupiec JJ, Santillana-Hayat M, Canivet M, Peries J, Emanoil-Ravier R. Further characterization of the gapped DNA intermediates of human spumavirus: evidence for a dual initiation of plus-strand DNA synthesis.. J Gen Virol 1991 Mar;72 ( Pt 3):605-8.
                        pubmed: 1848594doi: 10.1099/0022-1317-72-3-605google scholar: lookup
                      24. Wang G, Mulligan MJ. Comparative sequence analysis and predictions for the envelope glycoproteins of foamy viruses.. J Gen Virol 1999 Jan;80 ( Pt 1):245-254.
                        pubmed: 9934708doi: 10.1099/0022-1317-80-1-245google scholar: lookup
                      25. Winkler I, Bodem J, Haas L, Zemba M, Delius H, Flower R, Flügel RM, Löchelt M. Characterization of the genome of feline foamy virus and its proteins shows distinct features different from those of primate spumaviruses.. J Virol 1997 Sep;71(9):6727-41.
                        pmc: PMC191953pubmed: 9261397doi: 10.1128/JVI.71.9.6727-6741.1997google scholar: lookup
                      26. Yu SF, Baldwin DN, Gwynn SR, Yendapalli S, Linial ML. Human foamy virus replication: a pathway distinct from that of retroviruses and hepadnaviruses.. Science 1996 Mar 15;271(5255):1579-82.
                        pubmed: 8599113doi: 10.1126/science.271.5255.1579google scholar: lookup
                      27. Yu SF, Edelmann K, Strong RK, Moebes A, Rethwilm A, Linial ML. The carboxyl terminus of the human foamy virus Gag protein contains separable nucleic acid binding and nuclear transport domains.. J Virol 1996 Dec;70(12):8255-62.
                        pmc: PMC190912pubmed: 8970944doi: 10.1128/JVI.70.12.8255-8262.1996google scholar: lookup
                      28. Yu SF, Sullivan MD, Linial ML. Evidence that the human foamy virus genome is DNA.. J Virol 1999 Feb;73(2):1565-72.
                        pmc: PMC103981pubmed: 9882362doi: 10.1128/JVI.73.2.1565-1572.1999google scholar: lookup

                      Citations

                      This article has been cited 55 times.
                      1. AbuEed L, Makundi I, Miyake A, Kawasaki J, Minoura C, Koshida Y, Nishigaki K. Feline Foamy Virus Transmission in Tsushima Leopard Cats (Prionailurus bengalensis euptilurus) on Tsushima Island, Japan.. Viruses 2023 Mar 24;15(4).
                        doi: 10.3390/v15040835pubmed: 37112816google scholar: lookup
                      2. Wang X, Chen Y, Cui J. Identification of Cartilaginous Fish Endogenous Foamy Virus Rooting to Vertebrate Counterparts.. J Virol 2023 Feb 28;97(2):e0181622.
                        doi: 10.1128/jvi.01816-22pubmed: 36651746google scholar: lookup
                      3. Wang Z, Tuo X, Zhang J, Chai K, Tan J, Qiao W. Antiviral role of IFITM3 in prototype foamy virus infection.. Virol J 2022 Nov 22;19(1):195.
                        doi: 10.1186/s12985-022-01931-xpubmed: 36419065google scholar: lookup
                      4. Materniak-Kornas M, Rożek W, Rola J, Osiński Z, Löchelt M, Kuźmak J. Occurrence of Equine Foamy Virus Infection in Horses from Poland.. Viruses 2022 Sep 6;14(9).
                        doi: 10.3390/v14091973pubmed: 36146781google scholar: lookup
                      5. Zhang J, Han C, Xiong Z, Qiu M, Tuo X, Wang C, Qiao W, Tan J. SGK1, a Serine/Threonine Kinase, Inhibits Prototype Foamy Virus Replication.. Microbiol Spectr 2022 Jun 29;10(3):e0199521.
                        doi: 10.1128/spectrum.01995-21pubmed: 35438526google scholar: lookup
                      6. Wang Z, Li R, Liu C, Qiao W, Tan J. Characterization of Bovine Foamy Virus Gag Late Assembly Domain Motifs and Their Role in Recruiting ESCRT for Budding.. Viruses 2022 Mar 3;14(3).
                        doi: 10.3390/v14030522pubmed: 35336929google scholar: lookup
                      7. Sumiyoshi A, Kitao K, Miyazawa T. Genetic and biological characterization of feline foamy virus isolated from a leopard cat (Prionailurus bengalensis) in Vietnam.. J Vet Med Sci 2022 Jan 24;84(1):157-165.
                        doi: 10.1292/jvms.21-0550pubmed: 34880191google scholar: lookup
                      8. Chen Y, Zhang YY, Wei X, Cui J. Multiple Infiltration and Cross-Species Transmission of Foamy Viruses across the Paleozoic to the Cenozoic Era.. J Virol 2021 Jun 24;95(14):e0048421.
                        doi: 10.1128/JVI.00484-21pubmed: 33910951google scholar: lookup
                      9. Jaguva Vasudevan AA, Becker D, L T, Gohlke H, Münk C. Foamy Viruses, Bet, and APOBEC3 Restriction.. Viruses 2021 Mar 18;13(3).
                        doi: 10.3390/v13030504pubmed: 33803830google scholar: lookup
                      10. Okamoto M, Oguma K, Yamashita-Kawanishi N, Ichijo T, Hatama S, Endo M, Ishikawa M, Haga T. Genomic characterization and distribution of bovine foamy virus in Japan.. J Vet Med Sci 2020 Nov 12;82(11):1607-1613.
                        doi: 10.1292/jvms.20-0429pubmed: 32921656google scholar: lookup
                      11. Zhang J, Wang C, Tuo X, Chai K, Xu Y, Qiao W, Tan J. Prototype foamy virus downregulates RelB expression to facilitate viral replication.. FEBS Open Bio 2020 Oct;10(10):2137-2148.
                        doi: 10.1002/2211-5463.12968pubmed: 32881382google scholar: lookup
                      12. Materniak-Kornas M, Löchelt M, Rola J, Kuźmak J. Infection with Foamy Virus in Wild Ruminants-Evidence for a New Virus Reservoir?. Viruses 2020 Jan 3;12(1).
                        doi: 10.3390/v12010058pubmed: 31947727google scholar: lookup
                      13. Aiewsakun P. Avian and serpentine endogenous foamy viruses, and new insights into the macroevolutionary history of foamy viruses.. Virus Evol 2020 Jan;6(1):vez057.
                        doi: 10.1093/ve/vez057pubmed: 31942244google scholar: lookup
                      14. Murray SM, Linial ML. Simian Foamy Virus Co-Infections.. Viruses 2019 Sep 27;11(10).
                        doi: 10.3390/v11100902pubmed: 31569704google scholar: lookup
                      15. Kirisawa R, Toishi Y, Hashimoto H, Tsunoda N. Isolation of an Equine Foamy Virus and Sero-Epidemiology of the Viral Infection in Horses in Japan.. Viruses 2019 Jul 5;11(7).
                        doi: 10.3390/v11070613pubmed: 31284407google scholar: lookup
                      16. Zhang S, Liu X, Liang Z, Bing T, Qiao W, Tan J. The Influence of Envelope C-Terminus Amino Acid Composition on the Ratio of Cell-Free to Cell-Cell Transmission for Bovine Foamy Virus.. Viruses 2019 Jan 31;11(2).
                        doi: 10.3390/v11020130pubmed: 30708993google scholar: lookup
                      17. Hachiya Y, Kimura K, Oguma K, Ono M, Horikita T, Sentsui H. Isolation of bovine foamy virus in Japan.. J Vet Med Sci 2018 Nov 1;80(10):1604-1609.
                        doi: 10.1292/jvms.18-0121pubmed: 30175751google scholar: lookup
                      18. Pinto-Santini DM, Stenbak CR, Linial ML. Foamy virus zoonotic infections.. Retrovirology 2017 Dec 2;14(1):55.
                        doi: 10.1186/s12977-017-0379-9pubmed: 29197389google scholar: lookup
                      19. Ruboyianes R, Worobey M. Foamy-like endogenous retroviruses are extensive and abundant in teleosts.. Virus Evol 2016 Jul;2(2):vew032.
                        doi: 10.1093/ve/vew032pubmed: 28058112google scholar: lookup
                      20. Ball NJ, Nicastro G, Dutta M, Pollard DJ, Goldstone DC, Sanz-Ramos M, Ramos A, Müllers E, Stirnnagel K, Stanke N, Lindemann D, Stoye JP, Taylor WR, Rosenthal PB, Taylor IA. Structure of a Spumaretrovirus Gag Central Domain Reveals an Ancient Retroviral Capsid.. PLoS Pathog 2016 Nov;12(11):e1005981.
                        doi: 10.1371/journal.ppat.1005981pubmed: 27829070google scholar: lookup
                      21. Hamann MV, Lindemann D. Foamy Virus Protein-Nucleic Acid Interactions during Particle Morphogenesis.. Viruses 2016 Aug 30;8(9).
                        doi: 10.3390/v8090243pubmed: 27589786google scholar: lookup
                      22. Bing T, Zhang S, Liu X, Liang Z, Shao P, Zhang S, Qiao W, Tan J. Important role of N108 residue in binding of bovine foamy virus transactivator Tas to viral promoters.. Virol J 2016 Jun 30;13:117.
                        doi: 10.1186/s12985-016-0579-2pubmed: 27363487google scholar: lookup
                      23. Duan J, Tang Z, Mu H, Zhang G. Nuclear import of prototype foamy virus transactivator Bel1 is mediated by KPNA1, KPNA6 and KPNA7.. Int J Mol Med 2016 Aug;38(2):399-406.
                        doi: 10.3892/ijmm.2016.2635pubmed: 27277550google scholar: lookup
                      24. Zhang S, Cui X, Li J, Liang Z, Qiao W, Tan J. Lysine residues K66, K109, and K110 in the bovine foamy virus transactivator protein are required for transactivation and viral replication.. Virol Sin 2016 Apr;31(2):142-9.
                        doi: 10.1007/s12250-015-3652-xpubmed: 26980333google scholar: lookup
                      25. Materniak M, Kubiś P, Rola-Łuszczak M, Khan AS, Buseyne F, Lindemann D, Löchelt M, Kuźmak J. Tenth International Foamy Virus Conference 2014--achievements and perspectives.. Viruses 2015 Mar 31;7(4):1651-66.
                        doi: 10.3390/v7041651pubmed: 25835535google scholar: lookup
                      26. Katzourakis A, Aiewsakun P, Jia H, Wolfe ND, LeBreton M, Yoder AD, Switzer WM. Discovery of prosimian and afrotherian foamy viruses and potential cross species transmissions amidst stable and ancient mammalian co-evolution.. Retrovirology 2014 Aug 4;11:61.
                        doi: 10.1186/1742-4690-11-61pubmed: 25091111google scholar: lookup
                      27. Hu X, Yang W, Liu R, Geng Y, Qiao W, Tan J. N-Myc interactor inhibits prototype foamy virus by sequestering viral Tas protein in the cytoplasm.. J Virol 2014 Jun;88(12):7036-44.
                        doi: 10.1128/JVI.00799-14pubmed: 24719420google scholar: lookup
                      28. Bing T, Yu H, Li Y, Sun L, Tan J, Geng Y, Qiao W. Characterization of a full-length infectious clone of bovine foamy virus 3026.. Virol Sin 2014 Apr;29(2):94-102.
                        doi: 10.1007/s12250-014-3382-5pubmed: 24643936google scholar: lookup
                      29. Kehl T, Tan J, Materniak M. Non-simian foamy viruses: molecular virology, tropism and prevalence and zoonotic/interspecies transmission.. Viruses 2013 Sep 13;5(9):2169-209.
                        doi: 10.3390/v5092169pubmed: 24064793google scholar: lookup
                      30. Mouinga-Ondémé A, Kazanji M. Simian foamy virus in non-human primates and cross-species transmission to humans in Gabon: an emerging zoonotic disease in central Africa?. Viruses 2013 Jun 19;5(6):1536-52.
                        doi: 10.3390/v5061536pubmed: 23783811google scholar: lookup
                      31. Goldstone DC, Flower TG, Ball NJ, Sanz-Ramos M, Yap MW, Ogrodowicz RW, Stanke N, Reh J, Lindemann D, Stoye JP, Taylor IA. A unique spumavirus Gag N-terminal domain with functional properties of orthoretroviral matrix and capsid.. PLoS Pathog 2013 May;9(5):e1003376.
                        doi: 10.1371/journal.ppat.1003376pubmed: 23675305google scholar: lookup
                      32. Reh J, Stange A, Götz A, Rönitz M, Große A, Lindemann D. An N-terminal domain helical motif of Prototype Foamy Virus Gag with dual functions essential for particle egress and viral infectivity.. Retrovirology 2013 Apr 25;10:45.
                        doi: 10.1186/1742-4690-10-45pubmed: 23618494google scholar: lookup
                      33. Hütter S, Zurnic I, Lindemann D. Foamy virus budding and release.. Viruses 2013 Apr 10;5(4):1075-98.
                        doi: 10.3390/v5041075pubmed: 23575110google scholar: lookup
                      34. Müllers E. The foamy virus Gag proteins: what makes them different?. Viruses 2013 Mar 26;5(4):1023-41.
                        doi: 10.3390/v5041023pubmed: 23531622google scholar: lookup
                      35. Lee EG, Sinicrope A, Jackson DL, Yu SF, Linial ML. Foamy virus Pol protein expressed as a Gag-Pol fusion retains enzymatic activities, allowing for infectious virus production.. J Virol 2012 Jun;86(11):5992-6001.
                        doi: 10.1128/JVI.06979-11pubmed: 22491447google scholar: lookup
                      36. Mouinga-Ondémé A, Caron M, Nkoghé D, Telfer P, Marx P, Saïb A, Leroy E, Gonzalez JP, Gessain A, Kazanji M. Cross-species transmission of simian foamy virus to humans in rural Gabon, Central Africa.. J Virol 2012 Jan;86(2):1255-60.
                        doi: 10.1128/JVI.06016-11pubmed: 22072747google scholar: lookup
                      37. Lindemann D, Rethwilm A. Foamy virus biology and its application for vector development.. Viruses 2011 May;3(5):561-85.
                        doi: 10.3390/v3050561pubmed: 21994746google scholar: lookup
                      38. Guo HY, Liang ZB, Li Y, Tan J, Chen QM, Qiao WT. A new indicator cell line established to monitor bovine foamy virus infection.. Virol Sin 2011 Oct;26(5):315-23.
                        doi: 10.1007/s12250-011-3204-ypubmed: 21979571google scholar: lookup
                      39. Müllers E, Stirnnagel K, Kaulfuss S, Lindemann D. Prototype foamy virus gag nuclear localization: a novel pathway among retroviruses.. J Virol 2011 Sep;85(18):9276-85.
                        doi: 10.1128/JVI.00663-11pubmed: 21715475google scholar: lookup
                      40. Mouinga-Ondémé A, Betsem E, Caron M, Makuwa M, Sallé B, Renault N, Saib A, Telfer P, Marx P, Gessain A, Kazanji M. Two distinct variants of simian foamy virus in naturally infected mandrills (Mandrillus sphinx) and cross-species transmission to humans.. Retrovirology 2010 Dec 14;7:105.
                        doi: 10.1186/1742-4690-7-105pubmed: 21156043google scholar: lookup
                      41. Müllers E, Uhlig T, Stirnnagel K, Fiebig U, Zentgraf H, Lindemann D. Novel functions of prototype foamy virus Gag glycine- arginine-rich boxes in reverse transcription and particle morphogenesis.. J Virol 2011 Feb;85(4):1452-63.
                        doi: 10.1128/JVI.01731-10pubmed: 21106749google scholar: lookup
                      42. Wang J, Guo HY, Jia R, Xu X, Tan J, Geng YQ, Qiao WT. Preparation of BFV Gag antiserum and preliminary study on cellular distribution of BFV.. Virol Sin 2010 Apr;25(2):115-22.
                        doi: 10.1007/s12250-010-3110-8pubmed: 20960308google scholar: lookup
                      43. Wang J, Tan J, Guo H, Zhang Q, Jia R, Xu X, Geng Y, Qiao W. Bovine foamy virus transactivator BTas interacts with cellular RelB to enhance viral transcription.. J Virol 2010 Nov;84(22):11888-97.
                        doi: 10.1128/JVI.01036-10pubmed: 20844054google scholar: lookup
                      44. Calattini S, Betsem EB, Froment A, Mauclère P, Tortevoye P, Schmitt C, Njouom R, Saib A, Gessain A. Simian foamy virus transmission from apes to humans, rural Cameroon.. Emerg Infect Dis 2007 Sep;13(9):1314-20.
                        doi: 10.3201/eid1309.061162pubmed: 18252101google scholar: lookup
                      45. Calattini S, Wanert F, Thierry B, Schmitt C, Bassot S, Saib A, Herrenschmidt N, Gessain A. Modes of transmission and genetic diversity of foamy viruses in a Macaca tonkeana colony.. Retrovirology 2006 Apr 11;3:23.
                        doi: 10.1186/1742-4690-3-23pubmed: 16608518google scholar: lookup
                      46. Cartellieri M, Herchenröder O, Rudolph W, Heinkelein M, Lindemann D, Zentgraf H, Rethwilm A. N-terminal Gag domain required for foamy virus particle assembly and export.. J Virol 2005 Oct;79(19):12464-76.
                        doi: 10.1128/JVI.79.19.12464-12476.2005pubmed: 16160174google scholar: lookup
                      47. Geiselhart V, Bastone P, Kempf T, Schnölzer M, Löchelt M. Furin-mediated cleavage of the feline foamy virus Env leader protein.. J Virol 2004 Dec;78(24):13573-81.
                        doi: 10.1128/JVI.78.24.13573-13581.2004pubmed: 15564468google scholar: lookup
                      48. Bastone P, Truyen U, Löchelt M. Potential of zoonotic transmission of non-primate foamy viruses to humans.. J Vet Med B Infect Dis Vet Public Health 2003 Nov;50(9):417-23.
                        doi: 10.1046/j.0931-1793.2003.00704.xpubmed: 14633194google scholar: lookup
                      49. Shaw KL, Lindemann D, Mulligan MJ, Goepfert PA. Foamy virus envelope glycoprotein is sufficient for particle budding and release.. J Virol 2003 Feb;77(4):2338-48.
                        doi: 10.1128/jvi.77.4.2338-2348.2003pubmed: 12551971google scholar: lookup
                      50. Lecellier CH, Neves M, Giron ML, Tobaly-Tapiero J, Saïb A. Further characterization of equine foamy virus reveals unusual features among the foamy viruses.. J Virol 2002 Jul;76(14):7220-7.
                        doi: 10.1128/jvi.76.14.7220-7227.2002pubmed: 12072521google scholar: lookup
                      51. Lecellier CH, Vermeulen W, Bachelerie F, Giron ML, Saïb A. Intra- and intercellular trafficking of the foamy virus auxiliary bet protein.. J Virol 2002 Apr;76(7):3388-94.
                        doi: 10.1128/jvi.76.7.3388-3394.2002pubmed: 11884565google scholar: lookup
                      52. Wilk T, Geiselhart V, Frech M, Fuller SD, Flügel RM, Löchelt M. Specific interaction of a novel foamy virus Env leader protein with the N-terminal Gag domain.. J Virol 2001 Sep;75(17):7995-8007.
                        doi: 10.1128/jvi.75.17.7995-8007.2001pubmed: 11483744google scholar: lookup
                      53. Eastman SW, Linial ML. Identification of a conserved residue of foamy virus Gag required for intracellular capsid assembly.. J Virol 2001 Aug;75(15):6857-64.
                        doi: 10.1128/JVI.75.15.6857-6864.2001pubmed: 11435565google scholar: lookup
                      54. Tobaly-Tapiero J, Bittoun P, Giron ML, Neves M, Koken M, Saïb A, de Thé H. Human foamy virus capsid formation requires an interaction domain in the N terminus of Gag.. J Virol 2001 May;75(9):4367-75.
                        doi: 10.1128/JVI.75.9.4367-4375.2001pubmed: 11287585google scholar: lookup
                      55. Meiering CD, Linial ML. Historical perspective of foamy virus epidemiology and infection.. Clin Microbiol Rev 2001 Jan;14(1):165-76.
                        doi: 10.1128/CMR.14.1.165-176.2001pubmed: 11148008google scholar: lookup
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