Isolation of equine herpesvirus 1 from the brain of a horse affected with paresis.
Abstract: This research paper discusses the isolation of equine herpesvirus 1 (EHV1) from the brain of a horse experiencing paresis, demonstrating the connection between EHV1 infections and neurological disorders like ataxia, […]
Publication Date: 1985-10-01 PubMed ID: 3002312DOI: 10.1111/j.1751-0813.1985.tb07660.xGoogle Scholar: Lookup
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Summary
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This research paper discusses the isolation of equine herpesvirus 1 (EHV1) from the brain of a horse experiencing paresis, demonstrating the connection between EHV1 infections and neurological disorders like ataxia, paresis, and paraplegia in these animals.
Background on EHV1 and its effects
- This paper builds upon the growing body of knowledge on EHV1, a virus which has been increasingly implicated, particularly in North America and Europe, as a causative agent of neurological conditions like ataxia, paresis, and paraplegia in horses.
- Though the virus has previously been isolated from the central nervous system (CNS) of affected horses, such instances have been infrequent. The research of Little and Thorsen (1976) and Thein (1981) is cited here as documentation of prior successful attempts at virus isolation from the CNS of an afflicted animal.
EHV1 in Australia
- In the context of Australia, EHV1 infections are primarily coupled with respiratory illnesses in horses. However, there have been isolated incidents of EHV1-induced abortion cases in certain regions, including New South Wales as reported by Sabine et al. (1982) and Victoria as observed by Westbury et al. (1978).
- Investigations conducted in 1981 and 1982 were focused on distinct instances of clinical diseases suggestive of EHV1-impacted CNS disorders. However, during this period, the researchers could not detect any significant alterations in serum antibody titres to EHV1, indicating no discernible increase in the body’s immune response to the virus.
The Current Study
- The crux of this paper then is their successful isolation of EHV1 from the brain of a horse displaying paresis. The study thereby provides concrete evidence of the virus’s involvement in eliciting neurologically-driven distress in horses. Such discoveries further underscore the potential neurotropism of EHV1 that can culminate in severe disorders like paraplegia, ataxia, or paresis.
Cite This Article
APA
Carroll CL, Westbury HA.
(1985).
Isolation of equine herpesvirus 1 from the brain of a horse affected with paresis.
Aust Vet J, 62(10), 345-346.
https://doi.org/10.1111/j.1751-0813.1985.tb07660.x Publication
Researcher Affiliations
MeSH Terms
- Animals
- Brain / microbiology
- Herpesviridae / isolation & purification
- Herpesviridae Infections / veterinary
- Herpesvirus 1, Equid / isolation & purification
- Horse Diseases / microbiology
- Horses
- Male
- Paralysis / etiology
- Paralysis / veterinary
Citations
This article has been cited 12 times.- Tombácz D, Torma G, Gulyás G, Fülöp Á, Dörmő Á, Prazsák I, Csabai Z, Mizik M, Hornyák Á, Zádori Z, Kakuk B, Boldogkői Z. Hybrid sequencing discloses unique aspects of the transcriptomic architecture in equid alphaherpesvirus 1. Heliyon 2023 Jul;9(7):e17716.
- Kim SK, Shakya AK, O'Callaghan DJ. Interferon Gamma Inhibits Equine Herpesvirus 1 Replication in a Cell Line-Dependent Manner. Pathogens 2021 Apr 16;10(4).
- Kim SK, Shakya AK, O'Callaghan DJ. Intranasal treatment with CpG-B oligodeoxynucleotides protects CBA mice from lethal equine herpesvirus 1 challenge by an innate immune response. Antiviral Res 2019 Sep;169:104546.
- Shakya AK, O'Callaghan DJ, Kim SK. Comparative Genomic Sequencing and Pathogenic Properties of Equine Herpesvirus 1 KyA and RacL11. Front Vet Sci 2017;4:211.
- Kim SK, Shakya AK, O'Callaghan DJ. Immunization with Attenuated Equine Herpesvirus 1 Strain KyA Induces Innate Immune Responses That Protect Mice from Lethal Challenge. J Virol 2016 Sep 15;90(18):8090-104.
- Gupta AK, Kaur D, Rattan B, Yadav MP. Molecular variability in different Indian isolates of equine herpesvirus-1. Vet Res Commun 2005 Nov;29(8):721-34.
- Smith PM, Kahan SM, Rorex CB, von Einem J, Osterrieder N, O'Callaghan DJ. Expression of the full-length form of gp2 of equine herpesvirus 1 (EHV-1) completely restores respiratory virulence to the attenuated EHV-1 strain KyA in CBA mice. J Virol 2005 Apr;79(8):5105-15.
- Smith PM, Zhang Y, Grafton WD, Jennings SR, O'Callaghan DJ. Severe murine lung immunopathology elicited by the pathogenic equine herpesvirus 1 strain RacL11 correlates with early production of macrophage inflammatory proteins 1alpha, 1beta, and 2 and tumor necrosis factor alpha. J Virol 2000 Nov;74(21):10034-40.
- Smith PM, Zhang Y, Jennings SR, O'Callaghan DJ. Characterization of the cytolytic T-lymphocyte response to a candidate vaccine strain of equine herpesvirus 1 in CBA mice. J Virol 1998 Jul;72(7):5366-72.
- Tombácz D, Kakuk B, Torma G, Fülöp Á, Dörmő Á, Gulyás G, Csabai Z, Boldogkői Z. Mapping the temporal transcriptomic signature of a viral pathogen through CAGE and nanopore sequencing. PLoS One 2025;20(4):e0320439.
- Tombácz D, Maróti Z, Oláh P, Dörmő Á, Gulyás G, Kalmár T, Csabai Z, Boldogkői Z. Temporal transcriptional profiling of host cells infected by a veterinary alphaherpesvirus using nanopore sequencing. Sci Rep 2025 Jan 25;15(1):3247.
- Kasem S, Abdel-Moneim AS, Fukushi H. Effect of thymidine kinase-deficiency (∆ORF38) on neuropathogenicity of equine herpesvirus-1 in the mouse model and expression of neighboring genes. Virus Genes 2025 Apr;61(2):179-192.
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