Lidocaine constant rate infusion in isoflurane anesthetized neonatal foals.
Abstract: In horses, lidocaine infusion is administered intraoperatively for analgesia and for a reduction of inhalant anaesthetic requirement. The objective of the study was to describe the anaesthetic effects of lidocaine infusion in isoflurane anaesthetised foals. Unassigned: Twelve foals (<3 weeks old) undergoing surgery were included in the study (LIDO group). Foals were premedicated with midazolam and butorphanol IV, anaesthesia was induced with ketamine and propofol IV and maintained with isoflurane. Lidocaine was administered intraoperatively at 0.05 mg/kg/min. Also, the anaesthetic records of 11 foals in which lidocaine was not administered intraoperatively were retrospectively evaluated and they were considered as a historical control group (HC). Heart rate (HR), mean arterial pressure (MAP) and fraction of expired isoflurane were monitored continuously. Time of extubation, time to reach sternal recumbency and standing were recorded. The quality of recovery was assessed. Unassigned: HR decreased in both groups compared with baseline values and intraoperatively the differences were statistically significant ( = 0.01 and = 0.03 respectively in the LIDO and HC groups). Intraoperatively the HR was significantly lower in the LIDO group (71.2 ± 13.4 bpm) compared with the HC group (87.1 ± 17.7 bpm) ( = 0.0236). The number of foals requiring inotropic support (LIDO = 7 and HC = 9) was not statistically associated with the treatment group ( = 0.371). The extubation time, the time to reach the sternal recumbency and the quality of recovery did not differ significantly between the two groups ( = 0.7 and = 0.6 respectively). Unassigned: In conclusion, in anaesthetised foals the addition of lidocaine does not provide a sparing effect on isoflurane requirement, and it does not interfere with the quality of recovery, however it decreases significantly the HR, which is pivotal in foals for the maintenance of cardiac output and peripheral perfusion. Therefore, a continuous patient monitoring is essential.
Copyright © 2024 Lambertini, Spaccini, Mazzanti, Spadari, Lanci and Romagnoli.
Publication Date: 2024-01-17 PubMed ID: 38298459PubMed Central: PMC10828045DOI: 10.3389/fvets.2023.1304868Google Scholar: Lookup
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- Journal Article
Summary
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The research investigated the effects of Lidocaine infusion in foals (horses less than 3 weeks old) under isoflurane anesthesia during surgery. It was found that such infusion lowers the heart rate of the foals, but does not have a significant impact on the anesthetic needs or the quality of recovery.
Objective and Methodology
- The study aimed to explore the anaesthetic effects of lidocaine infusion in isoflurane anaesthetised foals.
- The study consisted of twelve foals undergoing surgery (referred as LIDO group), where lidocaine was administered intraoperatively.
- They were premedicated with midazolam and butorphanol IV, anesthesia was induced with ketamine and propofol IV and maintained with isoflurane.
- The researchers also examined the anaesthetic records of 11 foals where lidocaine was not used during surgery. These were treated as a historical control group (HC).
- Data on Heart rate (HR), mean arterial pressure (MAP) and fraction of expired isoflurane were continuously monitored. Information on extubation time, recovery time, and the overall quality of recovery were also noted.
Observations and Results
- Heart rate decreased in both groups compared with baseline values and there was a statistically significant intraoperative difference between LIDO and HC groups.
- The HR was significantly lower in the LIDO group (71.2 ± 13.4 bpm) compared with the HC group (87.1 ± 17.7 bpm).
- The requirement of inotropic support differed across individual foals in both groups, but it was not statistically associated with the treatment group.
- There were no significant differences found in extubation time, the time to reach the sternal recumbency (sternum-resting position) and the quality of recovery between the two groups.
Conclusions
- As per the study, the addition of lidocaine during surgeries on anesthetised foals does not significantly affect the isoflurane requirement or interfere with the quality of recovery.
- However, it significantly lowers the heart rate which is crucial in foals for maintaining cardiac output and peripheral perfusion.
- The researchers emphasized that continuous patient monitoring is essential when using Lidocaine in such situations.
Cite This Article
APA
Lambertini C, Spaccini F, Mazzanti A, Spadari A, Lanci A, Romagnoli N.
(2024).
Lidocaine constant rate infusion in isoflurane anesthetized neonatal foals.
Front Vet Sci, 10, 1304868.
https://doi.org/10.3389/fvets.2023.1304868 Publication
Researcher Affiliations
- Department of Veterinary Medical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
- Department of Veterinary Medical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
- Private Practitioner, Bologna, Italy.
- Department of Veterinary Medical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
- Department of Veterinary Medical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
- Department of Veterinary Medical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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