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Home / Equine Research Bank / BMC Vet Res / Neutrophil and macrophage apoptosis in bronchoalveolar lavag...
BMC veterinary research2014; 10; 29; doi: 10.1186/1746-6148-10-29

Neutrophil and macrophage apoptosis in bronchoalveolar lavage fluid from healthy horses and horses with recurrent airway obstruction (RAO).

Abstract: Dysregulation of apoptosis has been implicated in a range of diseases including tumors, neurodegenerative and autoimmune diseases, as well as allergic asthma and chronic obstructive pulmonary disease (COPD) in humans. Although it has a different pathophysiology, delayed apoptosis of various inflammatory cells may play a pivotal role in the development of recurrent airway obstruction (RAO) in horses. Reduction of inflammatory cell apoptosis or a dysregulation of this process could lead to chronic inflammation and tissue injury. Therefore, the aim of this study was to investigate the rate of apoptosis and necrosis of neutrophils and macrophages in bronchoalveolar lavage fluid obtained from seven horses suffering from RAO (study group) and seven control horses. Results: We demonstrated that neutrophil/macrophage apoptosis is altered in RAO-affected horses compared with the control group in the BAL fluid. We found a significant difference between the median percentage of early and late apoptosis of neutrophils between the study and control group of horses. Moreover, we found a positive correlation between the rate of apoptosis and the median percentage of macrophages in RAO-affected horses. Conclusions: The findings suggest that apoptosis dysregulation may play a significant role in the pathogenesis of RAO. However, further studies are needed to clarify the role of altered apoptosis in the course of equine recurrent airway obstruction.
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Publication Date: 2014-01-24 PubMed ID: 24460911PubMed Central: PMC3903020DOI: 10.1186/1746-6148-10-29Google Scholar: Lookup
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  • Journal Article
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  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article investigates the role of apoptosis (cell death) of immune cells in horses suffering from recurrent airway obstruction (RAO). The findings suggest that irregularities in apoptosis could be a significant contributor to the development of RAO in horses.

Introduction to the Study

  • The study focuses on investigating the rate of apoptosis (the process of programmed cell death) and necrosis (death of cells in response to injury or disease) in certain inflammatory cells, namely neutrophils and macrophages, in bronchoalveolar lavage fluid. This fluid is collected from the lungs and airways of horses suffering from Recurrent Airway Obstruction (RAO).
  • RAO is a pulmonary disease in horses, often compared to asthma or COPD in humans, which generally impacts the respiratory system leading to breathing difficulties.

Dysregulation of Apoptosis and RAO

  • The dysregulation (malfunction) of apoptosis plays a crucial role in the progression of various diseases, including tumors, neurodegenerative disorders, autoimmune diseases, allergic asthma and COPD in humans.
  • In the context of horses with RAO, delayed apoptosis in inflammatory cells might play a vital role in the development of chronic inflammation and tissue injury through its influence on the immune response.
  • In other words, when the inflammatory cells do not go through apoptosis as scheduled, they persist for an extended period, potentially resulting in chronic inflammation and subsequent damage to the tissue.

Study Findings

  • The researchers have noted a significant difference in the median percentage of early and late apoptosis of neutrophils between horses with RAO (study group) and control (healthy) horses.
  • Moreover, the study revealed a positive correlation between the rate of apoptosis and the median percentage of macrophages (a type of white blood cell) in horses afflicted with RAO. This means as the rate of apoptosis increases, so does the percentage of macrophages.
  • These findings suggest that the dysregulation of apoptosis could be contributing to the development and progression of RAO in horses.

Conclusion

  • While these findings indicate a possible link between apoptosis dysregulation and the pathogenesis of RAO, they also emphasize the need for additional research to fully understand the character of apoptosis and its impacts on this equine disease.

Cite This Article

APA
Niedzwiedz A, Jaworski Z, Tykalowski B, Smialek M. (2014). Neutrophil and macrophage apoptosis in bronchoalveolar lavage fluid from healthy horses and horses with recurrent airway obstruction (RAO). BMC Vet Res, 10, 29. https://doi.org/10.1186/1746-6148-10-29

Publication

BMC veterinary research
ISSN: 1746-6148
NlmUniqueID: 101249759
Country: England
Language: English
Volume: 10
Pages: 29

Researcher Affiliations

Niedzwiedz, Artur
  • Department of Internal Diseases with Clinic for Horses, Dogs and Cats, The Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, Pl, Grunwaldzki 47, Wrocław 50-366, Poland. artur.niedzwiedz@up.wroc.pl.
Jaworski, Zbigniew
    Tykalowski, Bartlomiej
      Smialek, Marcin

        MeSH Terms

        • Airway Obstruction / pathology
        • Airway Obstruction / veterinary
        • Animals
        • Apoptosis / physiology
        • Bronchoalveolar Lavage Fluid / cytology
        • Case-Control Studies
        • Female
        • Horse Diseases / pathology
        • Horses
        • Macrophages / cytology
        • Macrophages / physiology
        • Male
        • Neutrophils / cytology
        • Neutrophils / physiology

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        This article has been cited 13 times.
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