Observations on the transmission, immunology, clinical signs and chemotherapy of dourine (Trypanosoma equiperdum infection) in horses, with special reference to cerebro-spinal fluid.
Abstract: This paper is a record of observations on the transmission and clinical signs of dourine in naturally infected cases of known duration, and of temporal and quantitative aspects of the immune response in blood and cerebro-spinal fluid. Included in the record are observations on the presence of Trypanosoma equiperdum parasites in these body fluids and methods for their detection. There is evidence that the occurrence of nervous symptoms and lesions in infected horses is associated with the presence of Trypanosoma equiperdum parasites in cerebro-spinal fluid. The suitability of cerebro-spinal fluid as an environment for the parasite and its relationship with nervous manifestations of the disease are discussed. Observations support the previously reported lesions of peripheral polyneuritis and suggest a possible correltation between the consitstent position of the nervous lesions and the drainage of cerebro-spinal fluid containing the parasite. Chemotherapy with an experimental drug MSbE was used with varying results in 4 horses at different stages of infection.
Publication Date: 1976-06-01 PubMed ID: 1018890
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- Journal Article
Summary
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This research article covers the study of dourine, a disease in horses caused by Trypanosoma equiperdum infection, focusing particularly on how it is transmitted, its clinical signs, immune response it provokes, and treatment possibilities.
Transmission and Clinical Signs of Dourine
- The paper presents data on how dourine, a disease caused by Trypanosoma equiperdum, is transmitted among horses. They utilized naturally infected cases for their observations.
- The clinical signs of the disease were also observed and documented. These findings could potentially help identify infected animals by observing their symptoms.
Immune Response of Infected Hosts
- The research provides thorough insight into the immune response of infected horses. This includes temporal (time-related) and quantitative (in terms of amounts) aspects of the response.
- The researchers also paid particular attention to the immune response in the blood and cerebro-spinal fluid of the infected horses.
Detection of Trypanosoma equiperdum in Body Fluids
- The paper presents observations on the presence of Trypanosoma equiperdum parasites in the body fluids of infected horses. These include blood and cerebro-spinal fluid.
- The researchers used certain methods to detect the presence of these parasites in the body fluids. Being able to detect the parasites is key to making accurate diagnoses of the disease.
Cerebro-spinal Fluid and Nervous Symptoms in Infected Horses
- The researchers found evidence that nervous symptoms and lesions (abnormal changes in body tissue) observed in infected horses are associated with the presence of Trypanosoma equiperdum parasites in the cerebro-spinal fluid.
- The paper discusses the suitability of cerebro-spinal fluid as an environment for the parasite, and its possible relationship with nervous manifestations of the disease.
- Also, data support the possibility of a connection between nervous lesions’ location and cerebro-spinal fluid’s drainage containing the parasite.
Chemotherapy Treatment for Infected Horses
- An experimental drug identified as MSbE was used as a chemotherapy treatment for infected horses. The results were variable in different stages of infection, suggesting the potential value of early detection.
Cite This Article
APA
Barrowman PR.
(1976).
Observations on the transmission, immunology, clinical signs and chemotherapy of dourine (Trypanosoma equiperdum infection) in horses, with special reference to cerebro-spinal fluid.
Onderstepoort J Vet Res, 43(2), 55-66.
Publication
Researcher Affiliations
MeSH Terms
- Anemia / veterinary
- Animals
- Antimony / therapeutic use
- Blood / parasitology
- Cerebrospinal Fluid / parasitology
- Dourine / drug therapy
- Dourine / parasitology
- Dourine / transmission
- Edema / veterinary
- Female
- Horse Diseases / drug therapy
- Horse Diseases / parasitology
- Horse Diseases / transmission
- Horses
- Lymphadenitis / veterinary
- Male
- Trypanocidal Agents / therapeutic use
- Trypanosomiasis / veterinary
Citations
This article has been cited 3 times.- Yasine A, Ashenafi H, Geldhof P, Van Brantegem L, Vercauteren G, Bekana M, Tola A, Van Soom A, Duchateau L, Goddeeris B, Govaere J. Histopathological lesions in reproductive organs, distal spinal cord and peripheral nerves of horses naturally infected with Trypanosoma equiperdum.. BMC Vet Res 2019 May 28;15(1):175.
- Fikru R, Hagos A, Rogé S, Reyna-Bello A, Gonzatti MI, Merga B, Goddeeris BM, Büscher P. A proline racemase based PCR for identification of Trypanosoma vivax in cattle blood.. PLoS One 2014;9(1):e84819.
- Gari FR, Ashenafi H, Tola A, Goddeeris BM, Claes F. Comparative diagnosis of parasitological, serological, and molecular tests in dourine-suspected horses.. Trop Anim Health Prod 2010 Dec;42(8):1649-54.
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