Omneity® Pellets
All-In-One Vitamin & Mineral Pellet
[Occurrence of various immunoglobulin isotopes in horses with equine recurrent uveitis (ERU)].
Abstract: We investigated 30 healthy eyes and 41 eyes with ERU from 57 horses. The total immunoglobulin titers and titers of IgGa, IgGb, IgM were measured in aqueous humour, vitreous and serum using different ELISA techniques. Every sample investigated contained detectable amounts of immunoglobulins. Compared to control eyes significantly increased titers were found in the aqueous humour and vitreous of the ERU eyes for all immunoglobulin isotypes studied (p < or = 0.01). While IgM was detected in only 2 out of thirty aqueous humour and in none of the thirty vitreous samples of healthy eyes, 79.6% of samples of ERU eyes revealed considerable IgM titers. Changes of the IgGa/IgGb ratio in the eye as compared to that in the autologous serum was more frequent in affected than in healthy eyes. In contrast to the intraocular immunoglobulins there were no significant differences in immunoglobulin serum titers in healthy horses and those affected with ERU (p > 0.05). In conclusion, the results argue for a physiological appearance of immunoglobulins in the healthy eye. The increased titers of immunoglobulins in eyes stricken with ERU might be signs either of a local ocular production of antibodies and/or an increased permeability of intraocular barriers.
Publication Date: 2000-08-05 PubMed ID: 10925516 The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- English Abstract
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This research investigated immunoglobulin levels in the eyes of horses with equine recurrent uveitis (ERU), compared to healthy horses. The study found that horses with ERU have significantly higher levels of all types of immunoglobulins measured in their eye fluid, suggesting possible local production of antibodies or increased permeability of intraocular barriers in affected horses.
Participant Selection
In the research, the eyes of 57 horses were investigated. This included 30 healthy eyes and 41 eyes affected by equine recurrent uveitis (ERU).
Procedure and Techniques
Total immunoglobulin titers and titers of specific immunoglobulins (IgGa, IgGb, IgM) were measured in the aqueous humour, vitreous, and serum of the horses. This was achieved using a variety of enzyme-linked immunosorbent assay (ELISA) techniques.
Findings
- All samples investigated contained detectable amounts of immunoglobulins, regardless of health status.
- Significantly increased titers of all immunoglobulin types studied were found in the aqueous humour and vitreous fluid of ERU-affected eyes, as compared to the control (healthy) eyes.
- In the case of IgM, while it was detected in only 2 out of 30 aqueous humour samples and none of the vitreous samples of healthy eyes, around 80% samples of ERU eyes revealed considerable IgM levels.
- The ratio of IgGa to IgGb differed in the eye compared to the serum, more frequently in ERU-affected eyes than in healthy ones.
- No significant differences were found in the serum immunoglobulin levels of healthy horses as opposed to those affected by ERU, suggesting the differences observed were specific to ocular tissues.
Conclusions
Overall, the results point to a physiological appearance of immunoglobulins in a healthy eye. The heightened levels of immunoglobulins in the eyes affected by ERU could either be caused by local production of antibodies in response to inflammation or an increased permeability of the barriers in the eye, allowing more immunoglobulins to penetrate. Further research is needed to elucidate the exact mechanism and the potential therapeutic implications.
Cite This Article
APA
Eule JC, Wagner B, Leibold W, Deegen E.
(2000).
[Occurrence of various immunoglobulin isotopes in horses with equine recurrent uveitis (ERU)].
Berl Munch Tierarztl Wochenschr, 113(6), 253-257.
Publication
Researcher Affiliations
- Klinik für Pferde, Tierärztlichen Hochschule Hannover.
MeSH Terms
- Animals
- Aqueous Humor / immunology
- Horse Diseases / immunology
- Horses
- Immunoglobulin G / analysis
- Immunoglobulin Isotypes / analysis
- Immunoglobulin M / analysis
- Recurrence
- Reference Values
- Uveitis / immunology
- Uveitis / veterinary
- Vitreous Body / immunology
Citations
This article has been cited 2 times.- Kirmse L, Thieme K, Doherr MG, Eule JC. Evaluation of Laboratory Techniques for the Diagnosis of Leptospira-Associated Equine Recurrent Uveitis (ERU) With Focus on the Goldmann-Witmer Coefficient. Vet Ophthalmol 2026 Jan;29(1):e70132.
- Wollanke B, Gerhards H, Ackermann K. Infectious Uveitis in Horses and New Insights in Its Leptospiral Biofilm-Related Pathogenesis. Microorganisms 2022 Feb 7;10(2).
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
