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Home / Equine Research Bank / BMC Vet Res / Outbreak of equid herpesvirus 1 abortions at the Arabian stu...
BMC veterinary research2020; 16(1); 374; doi: 10.1186/s12917-020-02586-y

Outbreak of equid herpesvirus 1 abortions at the Arabian stud in Poland.

Abstract: Equid herpesvirus 1 (EHV-1) infections are endemic worldwide, including Poland. Many are subclinical, but some are associated with respiratory disease, abortion, neonatal foal death, or neurological disease. We describe an outbreak of abortions in Arabian mares at a well-managed State stud farm in Poland. Methods: Eight of 30 pregnant mares aborted and one gave birth to a weak foal that died within 72 h after birth. EHV-1 was isolated from all fetuses as well as from the diseased foal. All viruses belonged to the N variant based on the predicted open reading frame (ORF) 30 amino acid sequence. All were identical to each other and to previous EHV-1 viruses from the same stud based on the ORF68 sequence analysis. The outbreak coincided with the lapse in the routine yearly EHV-1/4 vaccinations of the mares. Conclusions: Multiple abortion due to EHV-1 infection can occur in well-managed groups of horses. Reactivation of latent EHV-1 in one of the resident mares followed by a horizontal spread was considered the most likely explanation for the outbreak. Routine vaccination is an important part of a herd-heath program.
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Publication Date: 2020-10-06 PubMed ID: 33023592PubMed Central: PMC7539464DOI: 10.1186/s12917-020-02586-yGoogle Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research discusses an outbreak of equid herpesvirus 1, a virus causing illnesses in horses, resulting in multiple abortions in a stud farm in Poland, stressing the importance of regular vaccinations.

Background of the Study

  • Equid herpesvirus 1 (EHV-1) is a common infection in horses worldwide, including Poland. While many of these infections are subclinical, meaning they do not show obvious signs of disease, they sometimes result in respiratory illness, abortions, death of young foals, or neurological disease.
  • This study specifically delves into an outbreak that led to abortions in Arabian mares in a state-owned stud farm known for its well-managed practices.

Method and Findings

  • The study involved 30 pregnant mares, out of which eight aborted and one gave birth to a weak foal that died within three days.
  • EHV-1 was isolated from all fetuses who aborted as well as the foal that died.
  • The isolated viruses belonged to the N variant, a specific type based on the predicted open reading frame (ORF) 30 amino acid sequence, an indicating feature of the virus.
  • All the viruses were identical to each other and were the same as previous EHV-1 viruses from the same stud farm, based on the analysis of the ORF68 sequence.
  • The outbreak took place at a time when there was a lapse in the routine yearly EHV-1/4 vaccinations for the mares.

Conclusion and Recommendations

  • Abortion due to EHV-1 infection can occur even in the best-managed horse groups, as showcased by the outbreak in the stud farm.
  • It is suspected that the source of the outbreak was a reactivation of latent EHV-1 in one of the resident mares, which then spread to others in close proximity.
  • The researchers recommend the importance of regular vaccinations in managing a healthy herd, which signifies the vital role of vaccination in preventing the outbreak of such diseases.

Cite This Article

APA
Stasiak K, Dunowska M, Rola J. (2020). Outbreak of equid herpesvirus 1 abortions at the Arabian stud in Poland. BMC Vet Res, 16(1), 374. https://doi.org/10.1186/s12917-020-02586-y

Publication

BMC veterinary research
ISSN: 1746-6148
NlmUniqueID: 101249759
Country: England
Language: English
Volume: 16
Issue: 1
Pages: 374
PII: 374

Researcher Affiliations

Stasiak, Karol
  • Department of Virology, National Veterinary Research Institute, Al. Partyzantow 57, 24-100, Pulawy, Poland.
Dunowska, Magdalena
  • Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston, North, New Zealand.
Rola, Jerzy
  • Department of Virology, National Veterinary Research Institute, Al. Partyzantow 57, 24-100, Pulawy, Poland. jrola@piwet.pulawy.pl.

MeSH Terms

  • Abortion, Veterinary / epidemiology
  • Abortion, Veterinary / virology
  • Animals
  • Animals, Newborn / virology
  • Disease Outbreaks / veterinary
  • Female
  • Herpesviridae Infections / pathology
  • Herpesviridae Infections / veterinary
  • Herpesvirus 1, Equid / genetics
  • Herpesvirus 1, Equid / isolation & purification
  • Horse Diseases / epidemiology
  • Horse Diseases / pathology
  • Horse Diseases / virology
  • Horses
  • Open Reading Frames
  • Poland / epidemiology
  • Pregnancy
  • Vaccination / veterinary

Conflict of Interest Statement

The authors declare that they have no competing interests.

References

This article includes 58 references
  1. Slater J. Equine herpesviruses. Equine infectious diseases St. Louis: Saunders Elsevier; 2007. p. 134–53.
  2. van Maanen C, Willink DL, Smeenk LA, Brinkhof J, Terpstra C. An equine herpesvirus 1 (EHV1) abortion storm at a riding school.. Vet Q 2000 Apr;22(2):83-7.
    doi: 10.1080/01652176.2000.9695030pubmed: 10789515google scholar: lookup
  3. Damiani AM, de Vries M, Reimers G, Winkler S, Osterrieder N. A severe equine herpesvirus type 1 (EHV-1) abortion outbreak caused by a neuropathogenic strain at a breeding farm in northern Germany.. Vet Microbiol 2014 Aug 27;172(3-4):555-62.
    doi: 10.1016/j.vetmic.2014.06.023pubmed: 25042527google scholar: lookup
  4. Frymus T, Kita J, Woyciechowska S, Ganowicz M. Foetal and neonatal foal losses on equine herpesvirus type 1(EHV-1) infected farms before and after EHV-1 vaccination was introduced.. Pol Arch Weter 1986;26(3-4):7-14.
    pubmed: 2830601
  5. van Maanen C, Sloet van Oldruitenborgh-Oosterbaan MM, Damen EA, Derksen AG. Neurological disease associated with EHV-1-infection in a riding school: clinical and virological characteristics.. Equine Vet J 2001 Mar;33(2):191-6.
    doi: 10.1111/j.2042-3306.2001.tb00600.xpubmed: 11266070google scholar: lookup
  6. Pronost S, Legrand L, Pitel PH, Wegge B, Lissens J, Freymuth F, Richard E, Fortier G. Outbreak of equine herpesvirus myeloencephalopathy in France: a clinical and molecular investigation.. Transbound Emerg Dis 2012 Jun;59(3):256-63.
    doi: 10.1111/j.1865-1682.2011.01263.xpubmed: 21975071google scholar: lookup
  7. Slater JD, Borchers K, Thackray AM, Field HJ. The trigeminal ganglion is a location for equine herpesvirus 1 latency and reactivation in the horse.. J Gen Virol 1994 Aug;75 ( Pt 8):2007-16.
    doi: 10.1099/0022-1317-75-8-2007pubmed: 8046404google scholar: lookup
  8. Chesters PM, Allsop R, Purewal A, Edington N. Detection of latency-associated transcripts of equid herpesvirus 1 in equine leukocytes but not in trigeminal ganglia.. J Virol 1997 May;71(5):3437-43.
    doi: 10.1128/JVI.71.5.3437-3443.1997pmc: PMC191489pubmed: 9094614google scholar: lookup
  9. Allen GP. Antemortem detection of latent infection with neuropathogenic strains of equine herpesvirus-1 in horses.. Am J Vet Res 2006 Aug;67(8):1401-5.
    doi: 10.2460/ajvr.67.8.1401pubmed: 16881853google scholar: lookup
  10. Kydd JH, Slater J, Osterrieder N, Lunn DP, Antczak DF, Azab W, Balasuriya U, Barnett C, Brosnahan M, Cook C, Damiani A, Elton D, Frampton A, Gilkerson J, Goehring L, Horohov D, Maxwell L, Minke J, Morley P, Nauwynck H, Newton R, Perkins G, Pusterla N, Soboll-Hussey G, Traub-Dargatz J, Townsend H, Van de Walle GR, Wagner B. Third International Havemeyer Workshop on Equine Herpesvirus type 1.. Equine Vet J 2012 Sep;44(5):513-7.
    doi: 10.1111/j.2042-3306.2012.00604.xpubmed: 22888774google scholar: lookup
  11. Gardiner DW, Lunn DP, Goehring LS, Chiang YW, Cook C, Osterrieder N, McCue P, Del Piero F, Hussey SB, Hussey GS. Strain impact on equine herpesvirus type 1 (EHV-1) abortion models: viral loads in fetal and placental tissues and foals.. Vaccine 2012 Oct 12;30(46):6564-72.
    doi: 10.1016/j.vaccine.2012.08.046pubmed: 22944628google scholar: lookup
  12. Prickett ME. The pathology of disease caused by equine herpesvirus 1. Equine infectious diseases II Proceedings of the Second International Conference on Equine Infectious Diseases, Paris 1969 Basel: S. Karger; 1970. pp. 24–33.
  13. Borchers K, Slater J. A nested PCR for the detection and differentiation of EHV-1 and EHV-4.. J Virol Methods 1993 Dec 31;45(3):331-6.
    doi: 10.1016/0166-0934(93)90117-Apubmed: 8106604google scholar: lookup
  14. Lawrence GL, Gilkerson J, Love DN, Sabine M, Whalley JM. Rapid, single-step differentiation of equid herpesviruses 1 and 4 from clinical material using the polymerase chain reaction and virus-specific primers.. J Virol Methods 1994 Apr;47(1-2):59-72.
    doi: 10.1016/0166-0934(94)90066-3pubmed: 8051234google scholar: lookup
  15. Pusterla N, Hussey SB, Mapes S, Johnson C, Collier JR, Hill J, Lunn DP, Wilson WD. Molecular investigation of the viral kinetics of equine herpesvirus-1 in blood and nasal secretions of horses after corticosteroid-induced recrudescence of latent infection.. J Vet Intern Med 2010 Sep-Oct;24(5):1153-7.
    doi: 10.1111/j.1939-1676.2010.0554.xpubmed: 20584139google scholar: lookup
  16. Pusterla N, Hussey SB, Mapes S, Leutenegger CM, Madigan JE, Ferraro GL, Wilson WD, Lunn DP. Comparison of four methods to quantify Equid herpesvirus 1 load by real-time polymerase chain reaction in nasal secretions of experimentally and naturally infected horses.. J Vet Diagn Invest 2009 Nov;21(6):836-40.
    doi: 10.1177/104063870902100611pubmed: 19901285google scholar: lookup
  17. Hussey SB, Clark R, Lunn KF, Breathnach C, Soboll G, Whalley JM, Lunn DP. Detection and quantification of equine herpesvirus-1 viremia and nasal shedding by real-time polymerase chain reaction.. J Vet Diagn Invest 2006 Jul;18(4):335-42.
    doi: 10.1177/104063870601800403pubmed: 16921871google scholar: lookup
  18. Allen GP, Bryans JT. Molecular epizootiology, pathogenesis, and prophylaxis of equine herpesvirus-1 infections.. Prog Vet Microbiol Immunol 1986;2:78-144.
    pubmed: 2856183
  19. Schulman ML, Becker A, van der Merwe BD, Guthrie AJ, Stout TA. Epidemiology and reproductive outcomes of EHV-1 abortion epizootics in unvaccinated Thoroughbred mares in South Africa.. Equine Vet J 2015 Mar;47(2):155-9.
    doi: 10.1111/evj.12264pubmed: 24617603google scholar: lookup
  20. Walter J, Seeh C, Fey K, Bleul U, Osterrieder N. Clinical observations and management of a severe equine herpesvirus type 1 outbreak with abortion and encephalomyelitis.. Acta Vet Scand 2013 Mar 5;55(1):19.
    doi: 10.1186/1751-0147-55-19pmc: PMC3630004pubmed: 23497661google scholar: lookup
  21. Slater JD, Lunn DP, Horohov DW, Antczak DF, Babiuk L, Breathnach C, Chang YW, Davis-Poynter N, Edington N, Ellis S, Foote C, Goehring L, Kohn CW, Kydd J, Matsumura T, Minke J, Morley P, Mumford J, Neubauer T, O'Callaghan D, Osterrieder K, Reed S, Smith K, Townsend H, van der Meulen K, Whalley M, Wilson WD. Report of the equine herpesvirus-1 Havermeyer Workshop, San Gimignano, Tuscany, June 2004.. Vet Immunol Immunopathol 2006 May 15;111(1-2):3-13.
    doi: 10.1016/j.vetimm.2006.01.004pubmed: 16542736google scholar: lookup
  22. Nugent J, Birch-Machin I, Smith KC, Mumford JA, Swann Z, Newton JR, Bowden RJ, Allen GP, Davis-Poynter N. Analysis of equid herpesvirus 1 strain variation reveals a point mutation of the DNA polymerase strongly associated with neuropathogenic versus nonneuropathogenic disease outbreaks.. J Virol 2006 Apr;80(8):4047-60.
    doi: 10.1128/JVI.80.8.4047-4060.2006pmc: PMC1440451pubmed: 16571821google scholar: lookup
  23. Cuxson JL, Hartley CA, Ficorilli NP, Symes SJ, Devlin JM, Gilkerson JR. Comparing the genetic diversity of ORF30 of Australian isolates of 3 equid alphaherpesviruses.. Vet Microbiol 2014 Feb 21;169(1-2):50-7.
    doi: 10.1016/j.vetmic.2013.12.007pubmed: 24418044google scholar: lookup
  24. Allen GP, Breathnach CC. Quantification by real-time PCR of the magnitude and duration of leucocyte-associated viraemia in horses infected with neuropathogenic vs. non-neuropathogenic strains of EHV-1.. Equine Vet J 2006 May;38(3):252-7.
    doi: 10.2746/042516406776866453pubmed: 16706281google scholar: lookup
  25. Stasiak K, Dunowska M, Hills SF, Rola J. Genetic characterization of equid herpesvirus type 1 from cases of abortion in Poland.. Arch Virol 2017 Aug;162(8):2329-2335.
    doi: 10.1007/s00705-017-3376-3pmc: PMC5506511pubmed: 28451902google scholar: lookup
  26. Malik P, Bálint A, Dán A, Pálfi V. Molecular characterisation of the ORF68 region of equine herpesvirus-1 strains isolated from aborted fetuses in Hungary between 1977 and 2008.. Acta Vet Hung 2012 Mar;60(1):175-87.
    doi: 10.1556/avet.2012.015pubmed: 22366142google scholar: lookup
  27. Garvey M, Lyons R, Hector RD, Walsh C, Arkins S, Cullinane A. Molecular Characterisation of Equine Herpesvirus 1 Isolates from Cases of Abortion, Respiratory and Neurological Disease in Ireland between 1990 and 2017.. Pathogens 2019 Jan 15;8(1).
    pmc: PMC6471309pubmed: 30650561doi: 10.3390/pathogens8010007google scholar: lookup
  28. Sutton G, Garvey M, Cullinane A, Jourdan M, Fortier C, Moreau P, Foursin M, Gryspeerdt A, Maisonnier V, Marcillaud-Pitel C, Legrand L, Paillot R, Pronost S. Molecular Surveillance of EHV-1 Strains Circulating in France during and after the Major 2009 Outbreak in Normandy Involving Respiratory Infection, Neurological Disorder, and Abortion.. Viruses 2019 Oct 4;11(10).
    doi: 10.3390/v11100916pmc: PMC6832873pubmed: 31590336google scholar: lookup
  29. Diallo IS, Hewitson G, Wright LL, Kelly MA, Rodwell BJ, Corney BG. Multiplex real-time PCR for the detection and differentiation of equid herpesvirus 1 (EHV-1) and equid herpesvirus 4 (EHV-4).. Vet Microbiol 2007 Jul 20;123(1-3):93-103.
    doi: 10.1016/j.vetmic.2007.02.004pubmed: 17346907google scholar: lookup
  30. Stasiak K, Dunowska M, Rola J. Prevalence and sequence analysis of equid herpesviruses from the respiratory tract of Polish horses.. Virol J 2018 Jul 11;15(1):106.
    doi: 10.1186/s12985-018-1018-3pmc: PMC6042439pubmed: 29996858google scholar: lookup
  31. Kimura M. A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences.. J Mol Evol 1980 Dec;16(2):111-20.
    doi: 10.1007/BF01731581pubmed: 7463489google scholar: lookup
  32. Kumar S, Stecher G, Tamura K. MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets.. Mol Biol Evol 2016 Jul;33(7):1870-4.
    doi: 10.1093/molbev/msw054pmc: PMC8210823pubmed: 27004904google scholar: lookup
  33. Cullinane A. Equine rhinopneumonitis (infection with equid herpesvirus-1 and -4). Manual of Diagnositc Tests and Vaccines for Terrestial Animals 2019: OIE World Organisation for Animal Health 2019.
  34. Smith KC, Blunden AS, Whitwell KE, Dunn KA, Wales AD. A survey of equine abortion, stillbirth and neonatal death in the UK from 1988 to 1997.. Equine Vet J 2003 Jul;35(5):496-501.
    doi: 10.2746/042516403775600578pubmed: 12875329google scholar: lookup
  35. Smith KC, Mumford JA, Lakhani K. A comparison of equid herpesvirus-1 (EHV-1) vascular lesions in the early versus late pregnant equine uterus.. J Comp Pathol 1996 Apr;114(3):231-47.
    doi: 10.1016/S0021-9975(96)80045-4pubmed: 8762581google scholar: lookup
  36. Edington N, Smyth B, Griffiths L. The role of endothelial cell infection in the endometrium, placenta and foetus of equid herpesvirus 1 (EHV-1) abortions.. J Comp Pathol 1991 May;104(4):379-87.
    doi: 10.1016/S0021-9975(08)80148-Xpubmed: 1651960google scholar: lookup
  37. Edington N, Bridges CG, Patel JR. Endothelial cell infection and thrombosis in paralysis caused by equid herpesvirus-1: equine stroke.. Arch Virol 1986;90(1-2):111-24.
    doi: 10.1007/BF01314149pubmed: 3015074google scholar: lookup
  38. Lunn DP, Davis-Poynter N, Flaminio MJ, Horohov DW, Osterrieder K, Pusterla N, Townsend HG. Equine herpesvirus-1 consensus statement.. J Vet Intern Med 2009 May-Jun;23(3):450-61.
    doi: 10.1111/j.1939-1676.2009.0304.xpubmed: 19645832google scholar: lookup
  39. Noronha LE, Antczak DF. Modulation of T-cell reactivity during equine pregnancy is antigen independent.. Am J Reprod Immunol 2012 Aug;68(2):107-15.
    doi: 10.1111/j.1600-0897.2012.01154.xpubmed: 22587222google scholar: lookup
  40. Perkins GA, Goodman LB, Dubovi EJ, Kim SG, Osterrieder N. Detection of equine herpesvirus-1 in nasal swabs of horses by quantitative real-time PCR.. J Vet Intern Med 2008 Sep-Oct;22(5):1234-8.
    doi: 10.1111/j.1939-1676.2008.0172.xpubmed: 18691363google scholar: lookup
  41. Gibson JS, Slater JD, Awan AR, Field HJ. Pathogenesis of equine herpesvirus-1 in specific pathogen-free foals: primary and secondary infections and reactivation.. Arch Virol 1992;123(3-4):351-66.
    doi: 10.1007/BF01317269pubmed: 1314051google scholar: lookup
  42. Soboll G, Hussey SB, Whalley JM, Allen GP, Koen MT, Santucci N, Fraser DG, Macklin MD, Swain WF, Lunn DP. Antibody and cellular immune responses following DNA vaccination and EHV-1 infection of ponies.. Vet Immunol Immunopathol 2006 May 15;111(1-2):81-95.
    doi: 10.1016/j.vetimm.2006.01.011pubmed: 16549215google scholar: lookup
  43. Foote CE, Gilkerson JR, Whalley JM, Love DN. Seroprevalence of equine herpesvirus 1 in mares and foals on a large Hunter Valley stud farm in years pre- and postvaccination.. Aust Vet J 2003 May;81(5):283-8.
    doi: 10.1111/j.1751-0813.2003.tb12576.xpubmed: 15084039google scholar: lookup
  44. Gilkerson JR, Whalley JM, Drummer HE, Studdert MJ, Love DN. Epidemiology of EHV-1 and EHV-4 in the mare and foal populations on a Hunter Valley stud farm: are mares the source of EHV-1 for unweaned foals.. Vet Microbiol 1999 Aug 16;68(1-2):27-34.
    doi: 10.1016/S0378-1135(99)00058-9pubmed: 10501159google scholar: lookup
  45. Gilkerson JR, Whalley JM, Drummer HE, Studdert MJ, Love DN. Epidemiological studies of equine herpesvirus 1 (EHV-1) in Thoroughbred foals: a review of studies conducted in the Hunter Valley of New South Wales between 1995 and 1997.. Vet Microbiol 1999 Aug 16;68(1-2):15-25.
    doi: 10.1016/S0378-1135(99)00057-7pubmed: 10501158google scholar: lookup
  46. Bresgen C, Lämmer M, Wagner B, Osterrieder N, Damiani AM. Serological responses and clinical outcome after vaccination of mares and foals with equine herpesvirus type 1 and 4 (EHV-1 and EHV-4) vaccines.. Vet Microbiol 2012 Nov 9;160(1-2):9-16.
    doi: 10.1016/j.vetmic.2012.04.042pubmed: 22633483google scholar: lookup
  47. Kydd JH, Townsend HG, Hannant D. The equine immune response to equine herpesvirus-1: the virus and its vaccines.. Vet Immunol Immunopathol 2006 May 15;111(1-2):15-30.
    doi: 10.1016/j.vetimm.2006.01.005pubmed: 16476492google scholar: lookup
  48. Goehring LS, Wagner B, Bigbie R, Hussey SB, Rao S, Morley PS, Lunn DP. Control of EHV-1 viremia and nasal shedding by commercial vaccines.. Vaccine 2010 Jul 19;28(32):5203-11.
    doi: 10.1016/j.vaccine.2010.05.065pubmed: 20538091google scholar: lookup
  49. Bürki F, Rossmanith W, Nowotny N, Pallan C, Möstl K, Lussy H. Viraemia and abortions are not prevented by two commercial equine herpesvirus-1 vaccines after experimental challenge of horses.. Vet Q 1990 Apr;12(2):80-6.
    doi: 10.1080/01652176.1990.9694249pubmed: 2163560google scholar: lookup
  50. Goehring LS, Landolt GA, Morley PS. Detection and management of an outbreak of equine herpesvirus type 1 infection and associated neurological disease in a veterinary teaching hospital.. J Vet Intern Med 2010 Sep-Oct;24(5):1176-83.
    doi: 10.1111/j.1939-1676.2010.0558.xpubmed: 20584137google scholar: lookup
  51. Burgess BA, Tokateloff N, Manning S, Lohmann K, Lunn DP, Hussey SB, Morley PS. Nasal shedding of equine herpesvirus-1 from horses in an outbreak of equine herpes myeloencephalopathy in Western Canada.. J Vet Intern Med 2012 Mar-Apr;26(2):384-92.
    doi: 10.1111/j.1939-1676.2012.00885.xpubmed: 22332764google scholar: lookup
  52. Goehring LS, van Maanen C, Berendsen M, Cullinane A, de Groot RJ, Rottier PJ, Wesselingh JJ, Sloet van Oldruitenborgh-Oosterbaan MM. Experimental infection with neuropathogenic equid herpesvirus type 1 (EHV-1) in adult horses.. Vet J 2010 Nov;186(2):180-7.
    doi: 10.1016/j.tvjl.2009.08.007pubmed: 19726209google scholar: lookup
  53. Mumford JA, Rossdale PD, Jessett DM, Gann SJ, Ousey J, Cook RF. Serological and virological investigations of an equid herpesvirus 1 (EHV-1) abortion storm on a stud farm in 1985.. J Reprod Fertil Suppl 1987;35:509-18.
    pubmed: 2824770
  54. Crabb BS, Studdert MJ. Equine herpesviruses 4 (equine rhinopneumonitis virus) and 1 (equine abortion virus).. Adv Virus Res 1995;45:153-90.
    doi: 10.1016/S0065-3527(08)60060-3pubmed: 7793324google scholar: lookup
  55. Allen GP. Risk factors for development of neurologic disease after experimental exposure to equine herpesvirus-1 in horses.. Am J Vet Res 2008 Dec;69(12):1595-600.
    doi: 10.2460/ajvr.69.12.1595pubmed: 19046006google scholar: lookup
  56. Kydd JH, Wattrang E, Hannant D. Pre-infection frequencies of equine herpesvirus-1 specific, cytotoxic T lymphocytes correlate with protection against abortion following experimental infection of pregnant mares.. Vet Immunol Immunopathol 2003 Dec 15;96(3-4):207-17.
    doi: 10.1016/j.vetimm.2003.08.004pubmed: 14592733google scholar: lookup
  57. Matczuk AK, Skarbek M, Jackulak NA, Bażanów BA. Molecular characterisation of equid alphaherpesvirus 1 strains isolated from aborted fetuses in Poland.. Virol J 2018 Dec 3;15(1):186.
    doi: 10.1186/s12985-018-1093-5pmc: PMC6276253pubmed: 30509297google scholar: lookup
  58. Bryant NA, Wilkie GS, Russell CA, Compston L, Grafham D, Clissold L, McLay K, Medcalf L, Newton R, Davison AJ, Elton DM. Genetic diversity of equine herpesvirus 1 isolated from neurological, abortigenic and respiratory disease outbreaks.. Transbound Emerg Dis 2018 Jun;65(3):817-832.
    doi: 10.1111/tbed.12809pmc: PMC5947664pubmed: 29423949google scholar: lookup

Citations

This article has been cited 5 times.
  1. Macleay CM, Carrick J, Shearer P, Begg A, Stewart M, Heller J, Chicken C, Brookes VJ. A Scoping Review of the Global Distribution of Causes and Syndromes Associated with Mid- to Late-Term Pregnancy Loss in Horses between 1960 and 2020. Vet Sci 2022 Apr 13;9(4).
    doi: 10.3390/vetsci9040186pubmed: 35448683google scholar: lookup
  2. Tong P, Duan R, Palidan N, Deng H, Duan L, Ren M, Song X, Jia C, Tian S, Yang E, Kuang L, Xie J. Outbreak of neuropathogenic equid herpesvirus 1 causing abortions in Yili horses of Zhaosu, North Xinjiang, China. BMC Vet Res 2022 Mar 1;18(1):83.
    doi: 10.1186/s12917-022-03171-1pubmed: 35232435google scholar: lookup
  3. Nielsen SS, Alvarez J, Bicout DJ, Calistri P, Canali E, Drewe JA, Garin-Bastuji B, Gonzales Rojas JL, Gortázar C, Herskin M, Michel V, Miranda Chueca MÁ, Roberts HC, Padalino B, Pasquali P, Spoolder H, Ståhl K, Calvo AV, Viltrop A, Winckler C, Carvelli A, Paillot R, Broglia A, Kohnle L, Baldinelli F, Van der Stede Y. Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): infection with Equine Herpesvirus-1. EFSA J 2022 Jan;20(1):e07036.
    doi: 10.2903/j.efsa.2022.7036pubmed: 35035581google scholar: lookup
  4. Kambayashi Y, Bannai H, Nemoto M, Kawanishi N, Niwa H, Tsujimura K. Comparative analysis of 3 qPCR primer-probe sets for the detection of equid alphaherpesvirus 1. J Vet Diagn Invest 2026 Jan;38(1):77-83.
    doi: 10.1177/10406387251379857pubmed: 41055561google scholar: lookup
  5. Tong P, Pan J, Dang Y, Yang E, Jia C, Duan R, Tian S, Palidan N, Kuang L, Wang C, Lu G, Xie J. First identification and isolation of equine herpesvirus type 1 in aborted fetal lung tissues of donkeys. Virol J 2024 May 27;21(1):117.
    doi: 10.1186/s12985-024-02390-2pubmed: 38802935google scholar: lookup
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