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Home / Equine Research Bank / BMC Vet Res / Outbreak of neuropathogenic equid herpesvirus 1 causing abor...
BMC veterinary research2022; 18(1); 83; doi: 10.1186/s12917-022-03171-1

Outbreak of neuropathogenic equid herpesvirus 1 causing abortions in Yili horses of Zhaosu, North Xinjiang, China.

Abstract: EHV-1 is one of the most serious viral pathogens that frequently cause abortion in horses around the world. However, so far, relatively little information is available on EHV-1 infections as they occur in China. In January 2021, during an abortion storm which occurred in Yili horses at the Chinese State Studs of Zhaosu (North Xinjiang, China), 43 out of 800 pregnant mares aborted. Results: PCR detection revealed the presence of EHV-1 in all samples as the possible cause of all abortions, although EHV-4, EHV-2 and EHV-5 were also found to circulate in the aborted fetuses. Furthermore, the partial ORF33 sequences of the 43 EHV-1 shared 99.3-100% and 99.0-100% similarity in nucleotide and amino acid sequences respectively. These sequences not only indicated a highly conserved region but also allowed the strains to group into six clusters. In addition, based on the predicted ORF30 nucleotide sequence, it was found that all the strains carried a guanine at the 2254 nucleotide position (aspartic acid at position 752 of the viral DNA polymerase) and were, therefore, identified as neuropathogenic strains. Conclusions: This study is the first one that establishes EHV-1 as the cause of abortions in Yili horses, of China. Further characterization of the ORF30 sequences revealed that all the EHV-1 strains from the study carried the neuropathogenic genotype. Totally, neuropathogenic EHV-1 infection in China's horse population should be concerned although the virus only detected in Yili horse abortions.
© 2022. The Author(s).
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Publication Date: 2022-03-01 PubMed ID: 35232435PubMed Central: PMC8886757DOI: 10.1186/s12917-022-03171-1Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article deals with an outbreak of neuropathogenic equid herpesvirus 1 (EHV-1) which caused a significant number of abortions in Yili horses in North Xinjiang, China in 2021. EHV-1 is highlighted as a serious viral pathogen causing horse abortions worldwide.

Study Overview

  • The study details an occurrence in January 2021, where 43 out of 800 pregnant mares at the Chinese State Studs of Zhaosu (North Xinjiang, China) experienced abortions. This abortion storm led to the investigation.
  • On analyzing the aborted fetuses, Polymerase Chain Reaction (PCR) detection found the presence of EHV-1 in all samples. There was also evidence of other strains of herpes virus including EHV-2, EHV-4, and EHV-5.

Key Research Findings

  • The partial ORF33 sequences of the 43 EHV-1 had a high degree of similarity, sharing 99.3-100% of nucleotide sequences and 99.0-100% of amino acid sequences. This revealed a highly conserved region among the viral strains.
  • The strains were grouped into six clusters based on these sequences.
  • The predicted ORF30 nucleotide sequence findings showed that all these strains were neuropathogenic, having a guanine at the 2254 nucleotide position of the viral DNA polymerase (aspartic acid at position 752).

Conclusion and Implications

  • The study concluded that EHV-1 was identified as the cause of abortions in Yili horses in China, marking the first time EHV-1 was found to be responsible in this region.
  • The EHV-1 strains discovered in this study all carried the neuropathogenic genotype.
  • The researchers suggested that more attention should be given to EHV-1 infection in China’s horse population, given that the neuropathogenic strain was found in the Yili horse abortions.

Cite This Article

APA
Tong P, Duan R, Palidan N, Deng H, Duan L, Ren M, Song X, Jia C, Tian S, Yang E, Kuang L, Xie J. (2022). Outbreak of neuropathogenic equid herpesvirus 1 causing abortions in Yili horses of Zhaosu, North Xinjiang, China. BMC Vet Res, 18(1), 83. https://doi.org/10.1186/s12917-022-03171-1

Publication

BMC veterinary research
ISSN: 1746-6148
NlmUniqueID: 101249759
Country: England
Language: English
Volume: 18
Issue: 1
Pages: 83
PII: 83

Researcher Affiliations

Tong, Panpan
  • Laboratory of Animal Etiology and Epidemiology, College of Veterinary Medicine, Xinjiang Agricultural University, Urumqi, Xinjiang, China.
Duan, Ruli
  • Laboratory of Animal Etiology and Epidemiology, College of Veterinary Medicine, Xinjiang Agricultural University, Urumqi, Xinjiang, China.
Palidan, Nuerlan
  • Laboratory of Animal Etiology and Epidemiology, College of Veterinary Medicine, Xinjiang Agricultural University, Urumqi, Xinjiang, China.
Deng, Haifeng
  • Zhaosu Horse Barn in Yili, Zhaosu, China.
Duan, Liya
  • Laboratory of Animal Etiology and Epidemiology, College of Veterinary Medicine, Xinjiang Agricultural University, Urumqi, Xinjiang, China.
  • Center of Animal Disease Control and Prevention, Acheng District, Harbin, Heilongjiang, China.
Ren, Meiling
  • Laboratory of Animal Etiology and Epidemiology, College of Veterinary Medicine, Xinjiang Agricultural University, Urumqi, Xinjiang, China.
  • Cisen Pharmaceutical Co., Ltd, Jining, Shandong, China.
Song, Xiaozhen
  • Laboratory of Animal Etiology and Epidemiology, College of Veterinary Medicine, Xinjiang Agricultural University, Urumqi, Xinjiang, China.
  • Tiankang biological Co., Ltd, Urumqi, Xinjiang, China.
Jia, Chenyang
  • Laboratory of Animal Etiology and Epidemiology, College of Veterinary Medicine, Xinjiang Agricultural University, Urumqi, Xinjiang, China.
Tian, Shuyao
  • Laboratory of Animal Etiology and Epidemiology, College of Veterinary Medicine, Xinjiang Agricultural University, Urumqi, Xinjiang, China.
Yang, Enhui
  • Laboratory of Animal Etiology and Epidemiology, College of Veterinary Medicine, Xinjiang Agricultural University, Urumqi, Xinjiang, China.
Kuang, Ling
  • Laboratory of Animal Etiology and Epidemiology, College of Veterinary Medicine, Xinjiang Agricultural University, Urumqi, Xinjiang, China. kuangling62@126.com.
Xie, Jinxin
  • Laboratory of Animal Etiology and Epidemiology, College of Veterinary Medicine, Xinjiang Agricultural University, Urumqi, Xinjiang, China. xiejinxin198683@163.com.

MeSH Terms

  • Abortion, Veterinary / epidemiology
  • Animals
  • Female
  • Herpesviridae Infections / epidemiology
  • Herpesviridae Infections / veterinary
  • Herpesvirus 1, Equid / genetics
  • Herpesvirus 4, Equid
  • Horse Diseases / epidemiology
  • Horses
  • Pregnancy

Grant Funding

  • 32060808 / National Natural Science Foundation of China
  • 2019M653901XB / Postdoctoral Research Foundation of China
  • 2019D01A47 / The Natural Science Foundation of Xinjiang Uyghur Autonomous Region
  • XJAU20180723 / Post-doctoral Science Foundation of Xinjiang Agricultural University
  • XJ20171123 / Xinjiang Uygur Autonomous Region High-Level Talent Introduction grants

Conflict of Interest Statement

The authors have declared no competing interests.

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Citations

This article has been cited 1 times.
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