Overview of the role and action mechanism of microRNA-128 in viral infections.
Abstract: Recently in vivo and in vitro studies have provided evidence establishing the significance of microRNAs (miRNAs) in both physiological and pathological conditions. In this regard, the role of miRNA-128 (miR-128) in health and diseases has been found, and its critical regulatory role in the context of some viral diseases has been recently identified. For instance, it has been found that miR-128 can serve as an antiviral mediator and significantly limit the replication and dissemination of human immunodeficiency virus type 1 (HIV-1). Besides, it has been noted that poliovirus receptor-related 4 (PVRL4) is post-transcriptionally regulated by miR-128, representing possible miRNA targets that can modulate measles virus infection. Of note, the downregulation of seminal exosomes eca-miR-128 is associated with the long-term persistence of Equine arteritis virus (EAV) in the reproductive tract, and this particular miRNA is a putative regulator of chemokine ligand 16 (C-X-C motif) as determined by target prediction analysis. In this review, the latest information on the role and action mechanism of miR-128 in viral infections will be summarized and discussed in detail.
Copyright © 2023 Elsevier Ltd. All rights reserved.
Publication Date: 2023-02-04 PubMed ID: 36746316DOI: 10.1016/j.micpath.2023.106020Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Review
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This research article is a comprehensive review focused on the role and action mechanism of microRNA-128 (miR-128) in viral infections. It discusses how miR-128 affects diseases and controls the spread of specific viruses, including HIV-1 and measles.
Role of miR-128 in Viral Infections
- The article reports that miR-128 plays a crucial regulatory role in certain viral diseases. Its effects have been studied both in lab conditions (in vitro) and in living organisms (in vivo). Studies have determined the importance of this microRNA in both health and disease states.
- One of the significant findings about this microRNA is that it can act as an antiviral mediator. It can substantially limit the replication and dissemination of the human immunodeficiency virus type 1 (HIV-1), contributing to the control of this disease.
Regulation by miR-128 and Effects on Measles Virus Infection
- The article further explains that poliovirus receptor-related 4 (PVRL4) is post-transcriptionally regulated by miR-128. The post-transcriptional regulation refers to controlling the rate at which a gene is expressed after the process of transcription, in which an RNA molecule is produced from a DNA template.
- An interesting finding about this microRNA is that there are potential targets for it that can modulate measles virus infection. By working on these targets, researchers could potentially manipulate the course of a measles virus infection.
Association of miR-128 with Equine Arteritis Virus (EAV)
- A poignant discovery made in the research is the correlation between the downregulation of seminal exosome miR-128 and the persistence of Equine arteritis virus (EAV) in the reproductive tract.
- This particular miRNA was determined to be a possible regulator of chemokine ligand 16 (C-X-C motif).
- The phenomenon of downregulation pertains to the decrease in the number or activity of cellular components such as RNA or protein, resulting from changes to certain mechanisms involved in gene expression.
Finally, this research article aims to supply a detailed review of the current information on the role and action mechanism of miR-128 in viral infections—a vital area of study for understanding biological responses to viral diseases.
Cite This Article
APA
Alshahrani SH, Alameri AA, Kahar F, Alexis Ramírez-Coronel A, Fadhel Obaid R, Alsaikhan F, Zabibah RS, Qasim QA, Altalbawy FMA, Fakri Mustafa Y, Mirzaei R, Karampoor S.
(2023).
Overview of the role and action mechanism of microRNA-128 in viral infections.
Microb Pathog, 176, 106020.
https://doi.org/10.1016/j.micpath.2023.106020 Publication
Researcher Affiliations
- Medical Surgical Nursing Department, King Khalid University, Almahala, Khamis Mushate, Saudi Arabia.
- Department of Chemistry, University of Babylon, Babylon, Iraq.
- Medic Technology Laboratory, Poltekkes Kemenkes Semarang, Indonesia.
- National University of Education, Azogues, Ecuador; Catholic University of Cuenca, Azogues Campus, Ecuador; University of Palermo, Buenos Aires, Argentina; CES University, Colombia, Azogues, Ecuador.
- Department of Biomedical Engineering, Al-Mustaqbal University College, Babylon, Iraq.
- College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj, Kingdom of Saudi Arabia.
- Medical Laboratory Technology Department, College of Medical Technology, The Islamic University, Najaf, Iraq.
- College of Pharmacy, Al-Ayen University, Thi-Qar, Iraq.
- National Institute of Laser Enhanced Sciences (NILES), Cairo University, Giza 12613, Egypt; Department of Chemistry, University College of Duba, Tabuk University, Duba 71911, Saudi Arabia.
- Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul 41001, Iraq.
- Venom and Biotherapeutics Molecules Lab, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran. Electronic address: rasul.micro92@gmail.com.
- Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran. Electronic address: karampour.s@iums.ac.ir.
MeSH Terms
- Animals
- Horses
- Humans
- MicroRNAs / genetics
- Down-Regulation
- Virus Diseases
- Genitalia
- Virus Replication
Conflict of Interest Statement
Declaration of competing interest None.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
