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Home / Equine Research Bank / J Periodontal Implant Sci / Periodontal regeneration capacity of equine particulate bone...
Journal of periodontal & implant science2010; 40(5); 220-226; doi: 10.5051/jpis.2010.40.5.220

Periodontal regeneration capacity of equine particulate bone in canine alveolar bone defects.

Abstract: This study was performed to evaluate the periodontal wound healing effect of particulate equine bone mineral on canine alveolar bone defects. Methods: Twelve adult male beagle dogs were used as study subjects. The mandibular second and fourth premolars were extracted prior to the experimental surgery, and the extraction sites were allowed to heal for 8 weeks. After periodontal probing, two-walled defects were created at the mesial and distal sides of the mandibular third premolars bilaterally, and the defects were filled with equine particulate bone with collagen membrane or bovine particulate bone with collagen membrane, or collagen membrane alone. The defects without any treatment served as negative controls. After probing depth measurement, animals were sacrificed at 10, 16, and 24 post-surgery weeks for micro-computed tomographic and histomorphometric analysis. Results: The equine particulate bone-inserted group showed significantly decreased values of probing depth and first bone contact compared to the negative control and collagen membrane alone groups at weeks 10, 16, and 24 (P < 0.05). There were no significant differences in the new cementum length, newly-formed bone area, or newly-formed bone volume between equine particulate bone- and bovine particulate bone-inserted groups, both of which showed significantly increased values compared to the negative control and collagen membrane alone groups (P < 0.05). Conclusions: Equine particulate bone showed significant differences in probing depth, first bone contact, new cementum length, newly formed bone area, and bone volume fraction values when compared to the negative control and collagen membrane alone groups. There were no significant differences between equine and bovine particulate bone substitutes in these parameters; therefore, we can conclude that equine particulate bone is equivalent to bovine bone for periodontal regeneration.
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Publication Date: 2010-10-31 PubMed ID: 21072218PubMed Central: PMC2967809DOI: 10.5051/jpis.2010.40.5.220Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study analyses the efficacy of equine bone mineral compared to bovine bone mineral for periodontal regeneration in dogs. It found that equine bone mineral is equally effective to bovine bone mineral for this purpose.

Research Methodology

  • Twelve adult male beagle dogs were the subjects of this study. To prepare for the experiment, the second and fourth premolars on their lower jaws were extracted. The extraction sites were then allowed to heal for a span of 8 weeks.
  • Post the healing period, two-walled defects were purposely created at the proximal and distal sides of the third premolars. These defects were then filled with either particulate equine bone mineral along with a collagen membrane, particulate bovine bone mineral along with a collagen membrane, or just a collagen membrane.
  • The defects were also left untreated in some instances as a negative control group. Following the surgery, the depth of the periodontal defects was recorded and analyzed at 10, 16, and 24 weeks respectively to understand the healing progress.
  • The dogs were then euthanized for further examination using micro-computed tomographic and histomorphometric analysis.

Findings

  • The initial findings pointed at a significantly reduced probing depth in the case of the equine particulate bone-inserted group as compared to the negative control and collagen membrane groups. This was consistent through weeks 10, 16, and 24.
  • The lengths of the new cementum, newly-formed bone area, and the volume showed no significant difference between groups treated with equine and bovine bone minerals. However, both these groups showed significantly greater values as compared to the control group and collagen membrane group.

Conclusion

  • For parameters such as probing depth, first bone contact, new cementum length, newly-formed bone area, and bone volume fraction values, the group treated with equine particulate bone saw significant improvements when compared to the negative control and collagen membrane alone groups.
  • The study therefore concludes that equine particulate bone is equivalent to bovine bone as a substance for periodontal regeneration. The efficacy of these bone minerals in regeneration can be applied in dentistry for superior dental health outcomes.

Cite This Article

APA
Kim TI, Chung CP, Heo MS, Park YJ, Rhee SH. (2010). Periodontal regeneration capacity of equine particulate bone in canine alveolar bone defects. J Periodontal Implant Sci, 40(5), 220-226. https://doi.org/10.5051/jpis.2010.40.5.220

Publication

Journal of periodontal & implant science
ISSN: 2093-2286
NlmUniqueID: 101526931
Country: Korea (South)
Language: English
Volume: 40
Issue: 5
Pages: 220-226

Researcher Affiliations

Kim, Tae-Il
  • Department of Periodontology and Dental Research Institute, Seoul National University School of Dentistry, Seoul, Korea.
Chung, Chong-Pyoung
    Heo, Min-Suk
      Park, Yoon-Jeong
        Rhee, Sang-Hoon

          Conflict of Interest Statement

          No potential conflict of interest relevant to this article was reported.

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          Citations

          This article has been cited 1 times.
          1. Cirligeriu L, Cimpean AM, Calniceanu H, Vladau M, Sarb S, Raica M, Nica L. Hyaluronic Acid/Bone Substitute Complex Implanted on Chick Embryo Chorioallantoic Membrane Induces Osteoblastic Differentiation and Angiogenesis, but not Inflammation. Int J Mol Sci 2018 Dec 19;19(12).
            doi: 10.3390/ijms19124119pubmed: 30572565google scholar: lookup
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