FREE SHIPPING over $40
OVER 10000 FIVE-STAR REVIEWS
5% OFF ALL SUBSCRIPTIONS
100% HAPPINESS GUARANTEE
Analyze Diet
0
Mammalian genome : official journal of the International Mammalian Genome Society2004; 15(10); 843-850; doi: 10.1007/s00335-004-2356-6

Polymorphisms in equine immune response genes and their associations with infections.

Abstract: Polymorphic markers identified in the horse genes encoding the interleukin 12 p40 subunit, interferon gamma, tumor necrosis factor receptor 1, and inducible nitric oxide synthase were identified and tested, along with additional markers, for associations with two important horse infections: Rhodococcus equi and Lawsonia intracellularis. Eight immune response-related and 14 microsatellite loci covering 12 out of 31 equine autosomes were used for the association analysis. Markers located on horse Chromosomes Eca10 and 15 were significantly associated with the presence of high numbers of R. equi in transtracheal aspirates. Significant associations of markers located on Eca9, 15, and 21 with fecal shedding of Lawsonia intracellularis were found. Marginal associations with tumor necrosis factor alpha, interferon gamma, and other genes suggested that variations in immune response-related genes could underlie the phenotypic variation observed.
Get Full Text
Publication Date: 2004-11-03 PubMed ID: 15520887DOI: 10.1007/s00335-004-2356-6Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
LinkedInCopy
  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research investigates how certain variations in horse immune response genes can be linked to two specific horse infections, Rhodococcus equi and Lawsonia intracellularis. The findings suggest that different genetic markers were significantly connected with the presence of these infections in horses.

Research Methodology

  • The researchers first identified polymorphic markers – changes in DNA sequence that occur within a population – in the equine genes responsible for certain aspects of the immune response. These genes coded for the interleukin 12 p40 subunit, interferon gamma, tumor necrosis factor receptor 1, and inducible nitric oxide synthase.
  • In addition to these identified markers, they also tested other markers for possible links to Rhodococcus equi and Lawsonia intracellularis infections in horses.
  • The study used a total of eight immune response-related markers and 14 microsatellite loci, which cover 12 of the 31 equine autosomes. Autosomes are chromosomes that are not sex chromosomes.

Key Findings

  • The study demonstrated that markers located on horse Chromosomes Eca10 and 15 were significantly associated with the presence of high numbers of R. equi in transtracheal aspirates – a diagnostic sample obtained from the horse’s windpipe.
  • Moreover, there were significant associations of markers located on Eca9, 15, and 21 with the horses’ fecal shedding of Lawsonia intracellularis – an important parameter of disease spread.

Implications and Conclusion

  • The findings suggest potential relationships between variations in immune response-related genes and the presence of these two specific horse infections.
  • Specifically, the connections with the tumor necrosis factor alpha, interferon gamma, and other related genes indicate that these variations could underlie the observed phenotypic variation.
  • This means that these genetic variations potentially lead to observable differences in the individual horse’s susceptibility or resistance to these infections.
  • This could provide further guidance for breeding decisions or for the development of targeted medical treatments for these infections in horses.

Cite This Article

APA
Horín P, Smola J, Matiasovic J, Vyskocil M, Lukeszová L, Tomanová K, Králík P, Glasnák V, Schröffelová D, Knoll A, Sedlinská M, Krenková L, Jahn P. (2004). Polymorphisms in equine immune response genes and their associations with infections. Mamm Genome, 15(10), 843-850. https://doi.org/10.1007/s00335-004-2356-6

Publication

Mammalian genome : official journal of the International Mammalian Genome Society
ISSN: 0938-8990
NlmUniqueID: 9100916
Country: United States
Language: English
Volume: 15
Issue: 10
Pages: 843-850

Researcher Affiliations

Horín, Petr
  • Faculty of Veterinary Medicine, Institute of Animal Genetics, Palackého 1/3, 61242 Brno, Czech Republic. horin@dior.ics.muni.cz.
Smola, Jirrí
    Matiasovic, Ján
      Vyskocil, Mirko
        Lukeszová, Ludmila
          Tomanová, Katarína
            Králík, Petr
              Glasnák, Vladimír
                Schröffelová, Dana
                  Knoll, Ales
                    Sedlinská, Markéta
                      Krenková, Leona
                        Jahn, Petr

                          MeSH Terms

                          • Animals
                          • Chromosomes, Mammalian / genetics
                          • Genes, MHC Class II / genetics
                          • Genes, MHC Class II / immunology
                          • Genetic Predisposition to Disease
                          • Horses / genetics
                          • Horses / immunology
                          • Horses / microbiology
                          • Interferon-gamma / genetics
                          • Interferon-gamma / immunology
                          • Interleukin-12 / genetics
                          • Interleukin-12 / immunology
                          • Lawsonia Bacteria / metabolism
                          • Nitric Oxide Synthase / genetics
                          • Nitric Oxide Synthase / immunology
                          • Nitric Oxide Synthase Type II
                          • Polymorphism, Genetic
                          • Rhodococcus equi / metabolism
                          • Tumor Necrosis Factor-alpha / genetics
                          • Tumor Necrosis Factor-alpha / immunology

                          References

                          This article includes 28 references
                          1. Vet Microbiol. 1997 Jun 16;56(3-4):257-68
                            pubmed: 9226840
                          2. J Appl Bacteriol. 1994 Sep;77(3):325-33
                            pubmed: 7989259
                          3. J Clin Microbiol. 1990 Mar;28(3):495-503
                            pubmed: 1691208
                          4. J Clin Microbiol. 1993 Oct;31(10):2611-5
                            pubmed: 8253956
                          5. Immunol Rev. 2002 Dec;190:169-81
                            pubmed: 12493014
                          6. Clin Infect Dis. 2002 May 15;34(10):1379-85
                            pubmed: 11981734
                          7. J Clin Microbiol. 1995 Jun;33(6):1624-7
                            pubmed: 7650199
                          8. Vet Pathol. 2003 Jul;40(4):421-32
                            pubmed: 12824514
                          9. Vet Microbiol. 2001 Oct 1;82(4):331-45
                            pubmed: 11506927
                          10. Mamm Genome. 2002 Sep;13(9):524-34
                            pubmed: 12370783
                          11. Genome Res. 2003 Apr;13(4):742-51
                            pubmed: 12671008
                          12. Vet Microbiol. 2003 Feb 2;91(2-3):135-45
                            pubmed: 12458163
                          13. J Clin Microbiol. 1979 May;9(5):640-2
                            pubmed: 479362
                          14. Vet Microbiol. 1997 Jun 16;56(3-4):167-76
                            pubmed: 9226831
                          15. Immunol Rev. 2002 Dec;190:9-25
                            pubmed: 12493003
                          16. Vet Microbiol. 1985 Apr;10(3):293-300
                            pubmed: 3923693
                          17. Curr Opin Immunol. 2002 Oct;14(5):609-14
                            pubmed: 12183161
                          18. Mamm Genome. 2003 Jul;14(7):448-53
                            pubmed: 12925893
                          19. Clin Diagn Lab Immunol. 2003 Mar;10(2):208-15
                            pubmed: 12626444
                          20. Pharmacogenomics J. 2002;2(6):349-60
                            pubmed: 12629506
                          21. Infect Immun. 1999 Oct;67(10):5041-7
                            pubmed: 10496876
                          22. Clin Diagn Lab Immunol. 2003 May;10(3):345-51
                            pubmed: 12738629
                          23. Eur J Immunogenet. 2002 Oct;29(5):423-9
                            pubmed: 12358853
                          24. Eur J Immunogenet. 2002 Aug;29(4):285-6
                            pubmed: 12121271
                          25. Equine Vet J. 2000 Sep;32(5):418-25
                            pubmed: 11037264
                          26. Genome Res. 1999 Dec;9(12):1239-49
                            pubmed: 10613847
                          27. J Med Primatol. 1999 Feb;28(1):11-8
                            pubmed: 10372536
                          28. Immunogenetics. 1998 May;47(6):487-90
                            pubmed: 9553156

                          Citations

                          This article has been cited 6 times.
                          1. da Silveira BP, Cohen ND, Lawhon SD, Watson RO, Bordin AI. Protective immune response against Rhodococcus equi: An innate immunity-focused review. Equine Vet J 2025 May;57(3):563-586.
                            doi: 10.1111/evj.14214pubmed: 39258739google scholar: lookup
                          2. Mukhopadhyay A, Cook SR, SanMiguel P, Ekenstedt KJ, Taylor SD. TLR4 and MD2 variation among horses with differential TNFα baseline concentrations and response to intravenous lipopolysaccharide infusion. Sci Rep 2023 Jan 27;13(1):1486.
                            doi: 10.1038/s41598-023-27956-ypubmed: 36707633google scholar: lookup
                          3. Hellman S, Hjertner B, Morein B, Fossum C. The adjuvant G3 promotes a Th1 polarizing innate immune response in equine PBMC. Vet Res 2018 Oct 22;49(1):108.
                            doi: 10.1186/s13567-018-0602-2pubmed: 30348190google scholar: lookup
                          4. McQueen CM, Whitfield-Cargile CM, Konganti K, Blodgett GP, Dindot SV, Cohen ND. TRPM2 SNP genotype previously associated with susceptibility to Rhodococcus equi pneumonia in Quarter Horse foals displays differential gene expression identified using RNA-Seq. BMC Genomics 2016 Dec 5;17(1):993.
                            doi: 10.1186/s12864-016-3345-3pubmed: 27919223google scholar: lookup
                          5. McQueen CM, Dindot SV, Foster MJ, Cohen ND. Genetic Susceptibility to Rhodococcus equi. J Vet Intern Med 2015 Nov-Dec;29(6):1648-59.
                            doi: 10.1111/jvim.13616pubmed: 26340305google scholar: lookup
                          6. Schurink A, Wolc A, Ducro BJ, Frankena K, Garrick DJ, Dekkers JC, van Arendonk JA. Genome-wide association study of insect bite hypersensitivity in two horse populations in the Netherlands. Genet Sel Evol 2012 Oct 30;44(1):31.
                            doi: 10.1186/1297-9686-44-31pubmed: 23110538google scholar: lookup
                          Subscribe to our newsletter
                          Join 99,970 horse owners like you who receive our email updates on horse health and nutrition.