Practical experience with the treatment of recipient mares with a non-steroidal anti-inflammatory drug in an equine embryo transfer programme.
Abstract: As part of a commercial embryo transfer programme, 20 embryos were transferred to spontaneously synchronous or synchronized recipient mares. In 14 cases, embryo recipients were treated with non-steroidal anti-inflammatory drugs (NSAID), receiving flunixin meglumine i.v. at the time of transfer and vedaprofen orally twice a day on the 3 days after embryo transfer, while six embryos were transferred to untreated mares that served as controls. Out of the 14 recipient mares treated with NSAID, 11 (79%) were pregnant at 6-8 days after transfer and in 10 mares, the pregnancy was continued. From the six untreated recipients, only one became pregnant but underwent early embryonic death between day 14 and 35 after ovulation. In conclusion, pregnancy rate in NSAID-treated recipients is higher than that in untreated recipients and above reported average values, indicating that treatment of recipient mares with NSAID helps to increase pregnancy rates after transcervical transfer and can be recommended for equine embryo transfer.
© 2009 Blackwell Verlag GmbH.
Publication Date: 2009-06-12 PubMed ID: 19515030DOI: 10.1111/j.1439-0531.2009.01486.xGoogle Scholar: Lookup
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Summary
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The study aimed to evaluate the use of non-steroidal anti-inflammatory drugs (NSAIDs) in improving pregnancy rates among recipient mares after embryonic transfer. The findings suggest that treatment of recipient mares with NSAIDs increased pregnancy rates after transfer when compared to untreated control group.
Research Methodology
- This study was conducted as part of a commercial embryo transfer programme.
- A total of 20 embryos were transferred to either spontaneously synchronous or synchronized recipient mares.
- Out of these, 14 recipient mares were treated with NSAIDs. The specific NSAIDs used were flunixin meglumine, which was provided intravenously at the time of transfer and vedaprofen, given orally twice a day for the three days after embryo transfer.
- The remaining six mares received no NSAID treatment and were used as a control group for this experiment.
Results of the Research
- The results indicated a higher success rate with the use of NSAIDs. Out of the 14 mare recipients treated with NSAIDs, 11 (79%) were pregnant 6-8 days post-transfer. For 10 of these mares, pregnancy continued, implying successful implantation of the embryos.
- Contrarily, of the six untreated mares, only one became pregnant, but she experienced early embryonic death between day 14 and 35 after ovulation.
- This implies a significantly higher effectiveness of NSAID usage in increasing pregnancy rates post-transcervical transfer in mares.
Conclusions from the Study
- Treatment of recipient mares with NSAID is associated with higher pregnancy rates than untreated mares, and the pregnancy rates also exceeded reported average values.
- The research therefore concludes that the use of NSAIDs as a treatment option for recipient mares helps to increase the success rates after embryonic transfer.
- This indicates the applicability of NSAIDs to improve outcomes in equine embryo transfer programmes and as such, its use can be recommended.
Cite This Article
APA
Koblischke P, Budik S, Müller J, Aurich C.
(2009).
Practical experience with the treatment of recipient mares with a non-steroidal anti-inflammatory drug in an equine embryo transfer programme.
Reprod Domest Anim, 45(6), 1039-1041.
https://doi.org/10.1111/j.1439-0531.2009.01486.x Publication
Researcher Affiliations
- Graf Lehndorff Institute for Equine Sciences, Brandenburg State Stud, Neustadt (Dosse), Germany.
MeSH Terms
- Animals
- Anti-Inflammatory Agents, Non-Steroidal / pharmacology
- Clonixin / analogs & derivatives
- Clonixin / pharmacology
- Embryo Transfer / veterinary
- Female
- Horses / physiology
- Naphthalenes / pharmacology
- Pregnancy
- Pregnancy Rate
- Pregnancy, Animal / drug effects
- Propionates / pharmacology
Citations
This article has been cited 4 times.- Dzięcioł M, Szpaczek A, Uchańska O, Niżański W. Influence of a Single Dose of Meloxicam Administrated during Canine Estrus on Progesterone Concentration and Fertility-A Clinical Case Study. Animals (Basel) 2022 Mar 4;12(5).
- Jaśkowski BM, Opałka A, Gehrke M, Herudzińska M, Czeladko J, Baumgartner W, Jaśkowski JM. A Critical Overview on Prostaglandin Inhibitors and Their Influence on Pregnancy Results after Insemination and Embryo Transfer in Cows. Animals (Basel) 2021 Nov 24;11(12).
- Alonso MA, Silva LA, Affonso FJ, Lemes KM, Celeghini ECC, Lançoni R, Carvalho HF, de Arruda RP. Effect of hCG application at different moments of the estrous cycle on corpus luteum and uterine vascularization and serum progesterone concentration in mares. Anim Reprod 2019 Oct 24;16(2):317-327.
- Schlapp G, Goyeneche L, Fernández G, Menchaca A, Crispo M. Administration of the nonsteroidal anti-inflammatory drug tolfenamic acid at embryo transfer improves maintenance of pregnancy and embryo survival in recipient mice. J Assist Reprod Genet 2015 Feb;32(2):271-5.
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