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Home / Equine Research Bank / Equine Vet J / Prospective, longitudinal assessment of subchondral bone mor...
Equine veterinary journal2024; doi: 10.1111/evj.14048

Prospective, longitudinal assessment of subchondral bone morphology and pathology using standing, cone-beam computed tomography in fetlock joints of 2-year-old Thoroughbred racehorses in their first year of training.

Abstract: Catastrophic injuries of the fetlock joints occur in Thoroughbred racehorses and are preceded by stress-induced bone injury. Early detection of subchondral bone injury is essential to prevent irreversible damage or bone failure. Objective: To investigate the use of standing, robotic cone-beam computed tomography (CBCT) for assessing longitudinal changes in subchondral bone morphology and pathology of the fetlock joints associated with race training in young Thoroughbreds. Methods: Observational cohort study. Methods: Forty-one 2-year-old Thoroughbred racehorses were recruited prior to the start of race training. Standing CBCT and radiographs of all 4 metacarpo-/metatarsophalangeal (MCP/MTP) joints were obtained at 0, 6 and 12 months. Hyperdensity, as an estimate of subchondral bone sclerosis, was measured in the distal third metacarpal (MC3)/metatarsal (MT3) bone and proximal phalanx (P1) at each time point on computed tomography. CBCTs were examined for subchondral bone pathology consisting of areas of hypodensity within regions of hyperdensity. Results: Subchondral bone sclerosis increased significantly over time in the medial and lateral MC3/MT3 condyles and in the medial and lateral parasagittal grooves of MC3/MT3. The presence of subchondral bone pathology increased significantly over time in the medial and lateral palmar condyles of MC3/MT3, the lateral parasagittal groove, the medial dorsal condyle and the medial and lateral ridges of P1. Conclusions: There was attrition of horses due to relocation, change in ownership, and retirement from racing. Husbandry, training regimens and racing schedules were not controlled for in the study. Conclusions: Standing CBCT is an efficient and effective screening tool for assessing subchondral bone morphology and identifying pathology of the fetlock joint in young Thoroughbred racehorses. CBCT may facilitate early detection of bone pathology allowing for timely intervention and prevention of more serious injuries. Unassigned: Katastrophale Verletzungen der Fesselgelenke treten bei Vollblutrennpferden auf und folgen belastungsinduzierten Knochenschäden. Die frühe Erkennung von subchondralen Knochenschäden ist essenziell, um irreversiblem Schaden oder Knochenversagen vorzubeugen. Unassigned: Untersuchung des Gebrauchs von stehend durchgeführter, robotischer Kegelstrahl-Computertomographie (CBCT) für die Beurteilung longitudinaler Veränderungen in subchondraler Knochenmorphologie und Pathologie der Fesselgelenke im Zusammenhang mit Renntraining bei jungen Vollblutpferden. Methods: Beobachtende Kohortenstudie. Methods: Einundvierzig zweijährige Vollblutrennpferde wurden vor Beginn des Renntrainings rekrutiert. Am stehenden Pferd durchgeführte CBCT und röntgenologische Untersuchung aller vier Metacarpo-/Metatarsophalangealgelenke (MCP/MTP) wurde zu den Zeitpunkten 0, 6 und 12 Monate wiederholt. Überdichte als eine Schätzung von subchondraler Knochensklerose wurde im distalen dritten Metacarpal-(MC3)/Metatarsal-(MT3) Knochen und der proximalen Phalanx zu jedem Zeitpunkt mithilfe der Computertomographie gemessen. CBCT wurden auf subchondrale Knochenpathologien bestehend aus hypodensen Bereichen innerhalb hyperdenser Regionen untersucht. Unassigned: Subchondrale Knochensklerose nahm im Laufe der Zeit in den medialen und lateralen MC3/MT3 Kondylen sowie in den medialen und lateralen parasagittalen Furchen signifikant zu. Das Vorhandensein subchondraler Knochenpathologien nahm im Laufe der Zeit in den Bereichen der medialen und lateralen palmaren Kondylen von MC3/MT3, der lateralen parasagittalen Furche, des medialen dorsalen Kondylus und der lateralen und medialen Kämme von P1 signifikant zu. HAUPTEINSCHRÄNKUNGEN: Pferde schieden aus der Studie aufgrund Standortwechsel, Besitzerwechsel, und Austritt aus dem Rennsport aus. Haltung, Trainingsregimente, und Rennpläne wurden für diese Studie nicht kontrolliert. Unassigned: Stehend durchgeführte CBCT ist ein effizientes und effektives Screening-Tool für die Beurteilung subchondraler Knochenmorphologie und Identifikation von Pathologie im Fesselgelenk junger Vollblutrennpferde. CBCT könnte frühe Erkennung von Knochenpathologie ermöglichen, was die rechtzeitige Intervention und Prävention von schwerwiegenderen Verletzungen ermöglicht.
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Publication Date: 2024-01-21 PubMed ID: 38247205DOI: 10.1111/evj.14048Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study explores the use of a medical imaging technique known as cone-beam computed tomography (CBCT) for identifying stress-related bone injuries in the fetlock joints of young Thoroughbred racehorses during their first year of training. The findings suggest that CBCT can help in tracking changes in bone morphology and detecting injuries early, potentially preventing catastrophic outcomes.

Objective and Methodology

  • The research aimed to use the standing, robotic CBCT as a tool for monitoring longitudinal changes in subchondral bone morphology and spotting pathological changes in the fetlock joints, which are associated with race training in young Thoroughbreds.
  • For the study, a cohort of 41 two-year-old Thoroughbred racehorses were enlisted, and their metacarpo-/metatarsophalangeal (MCP/MTP) joints were scanned using CBCT and radiographs at three intervals: at the start of race training, midway (at 6 months), and at the end of the first year (12 months).
  • Hyperdensity, indicating subchondral bone sclerosis, was calculated in the distal third metacarpal (MC3)/metatarsal (MT3) bone and proximal phalanx (P1) at each time point.
  • CBCT scans were specifically examined for pathology in the subchondral bone, identified as areas of hypodensity within regions of hyperdensity.

Results

  • It was observed that subchondral bone sclerosis significantly increased over time in the medial and lateral MC3/MT3 condyles and in the medial and lateral parasagittal grooves of MC3/MT3.
  • Similarly, the presence of subchondral bone pathology also significantly increased over time in various parts of the MC3/MT3 and P1.
  • These indicate that CBCT scans can effectively track changes in the bones over time, making it a useful tool for identifying early signs of stress-induced injuries.

Conclusions

  • Several horses had to be removed from the study due to reasons like relocation, change in ownership, and retirement from racing.
  • Factors like husbandry, training routines, and racing schedules were not controlled by the study, which could be treated as limitations.
  • Overall, standing CBCT is a movered as a highly efficient and effective method for longitudinal assessment of subchondral bone morphology and detecting early signs of injuries in young Thoroughbred racehorses.
  • By facilitating early detection of bone pathology, CBCT could aid in timely intervention and prevention of severe injuries.

Cite This Article

APA
Ciamillo SA, Wulster KB, Gassert TM, Richardson DW, Brown KA, Stefanovski D, Ortved KF. (2024). Prospective, longitudinal assessment of subchondral bone morphology and pathology using standing, cone-beam computed tomography in fetlock joints of 2-year-old Thoroughbred racehorses in their first year of training. Equine Vet J. https://doi.org/10.1111/evj.14048

Publication

Equine veterinary journal
ISSN: 2042-3306
NlmUniqueID: 0173320
Country: United States
Language: English

Researcher Affiliations

Ciamillo, Sarah A
  • Department of Clinical Studies-New Bolton Center, University of Pennsylvania, Kennett Square, Pennsylvania, USA.
Wulster, Kathryn B
  • Department of Clinical Studies-New Bolton Center, University of Pennsylvania, Kennett Square, Pennsylvania, USA.
Gassert, Taryn M
  • Sports Medicine Associates of Chester County, Cochranville, Pennsylvania, USA.
Richardson, Dean W
  • Department of Clinical Studies-New Bolton Center, University of Pennsylvania, Kennett Square, Pennsylvania, USA.
Brown, Kara A
  • Department of Clinical Studies-New Bolton Center, University of Pennsylvania, Kennett Square, Pennsylvania, USA.
Stefanovski, Darko
  • Department of Clinical Studies-New Bolton Center, University of Pennsylvania, Kennett Square, Pennsylvania, USA.
Ortved, Kyla F
  • Department of Clinical Studies-New Bolton Center, University of Pennsylvania, Kennett Square, Pennsylvania, USA.

Grant Funding

  • Grayson-Jockey Club Research Foundation

References

This article includes 41 references
  1. Riggs CM, Boyde A. Effect of exercise on bone density in distal regions of the equine third metacarpal bone in 2-year-old thoroughbreds.. Equine Vet J 1999;31(S30):555-560.
  2. Noble P, Singer ER, Jeffery NS. Does subchondral bone of the equine proximal phalanx adapt to race training?. J Anat 2016;229(1):104-113.
  3. Young DR, Nunamaker DM, Markel MD. Quantitative evaluation of the remodeling response of the proximal sesamoid bones to training-related stimuli in Thoroughbreds.. Am J Vet Res 1991;52:1350-1356.
  4. Martig S, Lee PVS, Anderson GA, Whitton RC. Compressive fatigue life of subchondral bone of the metacarpal condyle in thoroughbred racehorses.. Bone 2013;57:392-398.
  5. Norrdin RW, Stover SM. Subchondral bone failure in overload arthrosis: a scanning electron microscopic study in horses.. J Musculoskelet Neuronal Interact 2006;6:251-257.
  6. Dyson PK, Jackson BF, Pfeiffer DU, Price JS. Days lost from training by two- and three-year-old Thoroughbred horses: a survey of seven UK training yards.. Equine Vet J 2008;40:650-657.
  7. Barr ED, Pinchbeck GL, Clegg PD, Boyde A, Riggs CM. Post mortem evaluation of palmar osteochondral disease (traumatic osteochondrosis) of the metacarpo/metatarsophalangeal joint in Thoroughbred racehorses.. Equine Vet J 2009;41:366-371.
  8. Riggs CM, Whitehouse GH, Boyde A. Pathology of the distal condyles of the third metacarpal and third metatarsal bones of the horse.. Equine Vet J 1999;31:140-148.
  9. Reed SR, Jackson BF, McIlwraith CW, Wright IM, Pilsworth R, Knapp S. Descriptive epidemiology of joint injuries in Thoroughbred racehorses in training.. Equine Vet J 2012;44:13-19.
  10. Pinchbeck GL, Clegg PD, Boyde A, Riggs CM. Pathological and clinical features associated with palmar/plantar osteochondral disease of the metacarpo/metatarsophalangeal joint in Thoroughbred racehorses.. Equine Vet J 2013;45:587-592.
  11. Ramzan PHL, Palmer L. Musculoskeletal injuries in Thoroughbred racehorses: a study of three large training yards in Newmarket, UK (2005-2007).. Vet J 2011;187:325-329.
  12. Hill AE, Blea JA, Arthur RM, McIlwraith CW. Non-fatal injury occurrence in Southern California Thoroughbred racehorses 2009-2010.. Vet J 2015;205:98-100.
  13. Tull TM, Bramlage LR. Racing prognosis after cumulative stress-induced injury of the distal portion of the third metacarpal and third metatarsal bones in Thoroughbred racehorses: 55 cases (2000-2009).. J Am Vet Med Assoc 2011;238:1316-1322.
  14. Diab SS, Stover SM, Carvallo F, Nyaoke AC, Moore J, Hill A. Diagnostic approach to catastrophic musculoskeletal injuries in racehorses.. J Vet Diagn Invest 2017;29:405-413.
  15. Dubois M-S, Morello S, Rayment K, Markel MD, Vanderby R, Kalscheur VL. Computed tomographic imaging of subchondral fatigue cracks in the distal end of the third metacarpal bone in the Thoroughbred racehorse can predict crack micromotion in an ex-vivo model.. PloS One 2014;9:e101230.
  16. Vanderperren K, Ghaye B, Snaps FR, Saunders JH. Evaluation of computed tomographic anatomy of the equine metacarpophalangeal joint.. Am J Vet Res 2008;69:631-638.
  17. Curtiss AL, Ortved KF, Dallap-Schaer B, Gouzeev S, Stefanovski D, Richardson DW. Validation of standing cone beam computed tomography for diagnosing subchondral fetlock pathology in the Thoroughbred racehorse.. Equine Vet J 2021;53:510-523.
  18. O'Brien T, Baker T, Brounts S, Sample S, Markel M, Scollay M. Detection of articular pathology of the distal aspect of the third metacarpal bone in thoroughbred racehorses: comparison of radiography, computed tomography and magnetic resonance imaging.. Vet Surg 2011;40:942-951.
  19. Davis AM, Fan X, Shen L, Robinson P, Riggs CM. Improved radiological diagnosis of palmar osteochondral disease in the Thoroughbred racehorse.. Equine Vet J 2017;49:454-460.
  20. Olive J, D'Anjou M-A, Alexander K, Laverty S, Theoret C. Comparison of magnetic resonance imaging, computed tomography, and radiography for assessment of noncartilaginous changes in equine metacarpophalangeal osteoarthritis.. Vet Radiol Ultrasound 2010;51:267-279.
  21. Hosmer D, Lemeshow S, Sturdivant R. Assessing the fit of the model.. Applied logistic regression 3rd ed. Hoboken, NJ: John Wiley & Sons, Ltd.; 2013. p. 153-226.
  22. Lanyon LE. Functional strain in bone tissue as an objective, and controlling stimulus for adaptive bone remodelling.. J Biomech 1987;20:1083-1093.
  23. Turley SM, Thambyah A, Riggs CM, Firth EC, Broom ND. Microstructural changes in cartilage and bone related to repetitive overloading in an equine athlete model.. J Anat 2014;224:647-658.
  24. Whitton RC, Ayodele BA, Hitchens PL, Mackie EJ. Subchondral bone microdamage accumulation in distal metacarpus of Thoroughbred racehorses.. Equine Vet J 2018;50:766-773.
  25. Holmes JM, Mirams M, Mackie EJ, Whitton RC. Thoroughbred horses in race training have lower levels of subchondral bone remodelling in highly loaded regions of the distal metacarpus compared to horses resting from training.. Vet J 2014;202:443-447.
  26. Firth EC, Rogers CW, van Weeren PR, Barneveld A, Wayne McIlwraith CW, Kawcak CE. The effect of previous conditioning exercise on diaphyseal and metaphyseal bone to imposition and withdrawal of training in young Thoroughbred horses.. Vet J 2012;192:34-40.
  27. Parkin TDH, Clegg PD, French NP, Proudman CJ, Riggs CM, Singer ER. Catastrophic fracture of the lateral condyle of the third metacarpus/metatarsus in UK racehorses - fracture descriptions and pre-existing pathology.. Vet J 2006;171:157-165.
  28. Stewart HL, Kawcak CE. The importance of subchondral bone in the pathophysiology of osteoarthritis.. Front Vet Sci 2018;5:178.
  29. Kawack CE, McIlwraith CW. Proximodorsal first phalanx osteochondral chip fragmentation in 336 horses.. Equine Vet J 1994;26:392-396.
  30. Kawcak CE, McIlwraith CW, Norrdin RW, Park RD, Steyn PS. Clinical effects of exercise on subchondral bone of carpal and metacarpophalangeal joints in horses.. Am J Vet Res 2000;61:1252-1258.
  31. Cresswell EN, McDonough SP, Palmer SE, Hernandez CJ, Reesink HL. Can quantitative computed tomography detect bone morphological changes associated with catastrophic proximal sesamoid bone fracture in Thoroughbred racehorses?. Equine Vet J 2019;51:123-130.
  32. Shaffer SK, To C, Garcia TC, Fyhrie DP, Uzal FA, Stover SM. Subchondral focal osteopenia associated with proximal sesamoid bone fracture in Thoroughbred racehorses.. Equine Vet J 2021;53:294-305.
  33. Luedke LK, Ilevbare P, Noordwijk KJ, Palomino PM, McDonough SP, Palmer SE. Proximal sesamoid bone microdamage is localized to articular subchondral regions in Thoroughbred racehorses, with similar fracture toughness between fracture and controls.. Vet Surg 2022;51:952-962.
  34. Spriet M, Espinosa-Mur P, Cissell DD, Phillips KL, Arino-Estrada G, Beylin D. 18F-sodium fluoride positron emission tomography of the racing Thoroughbred fetlock: validation and comparison with other imaging modalities in nine horses.. Equine Vet J 2019;51:375-383.
  35. Spriet M. Positron emission tomography: a horse in the musculoskeletal imaging race.. Am J Vet Res 2022;83:ajvr.22.03.0051.
  36. Morgan JW, Santschi EM, Zekas LJ, Scollay-Ward MC, Markel MD, Radtke CL. Comparison of radiography and computed tomography to evaluate metacarpo/metatarsophalangeal joint pathology of paired limbs of thoroughbred racehorses with severe condylar fracture.. Vet Surg 2006;35:611-617.
  37. Johnston GCA, Ahern BJ, Palmieri C, Young AC. Imaging and gross pathological appearance of changes in the parasagittal grooves of Thoroughbred racehorses.. Animals 2021;11:3366.
  38. Drum MG, Les CM, Park RD, Norrdin RW, McIlwraith CW, Kawcak CE. Correlation of quantitative computed tomographic subchondral bone density and ash density in horses.. Bone 2009;44:316-319.
  39. Olive J, d'Anjou M-A, Alexander K, Beauchamp G, Theoret CL. Correlation of signal attenuation-based quantitative magnetic resonance imaging with quantitative computed tomographic measurements of subchondral bone mineral density in metacarpophalangeal joints of horses.. Am J Vet Res 2010;71:412-420.
  40. Riggs CM. Computed tomography in equine orthopaedics - the next great leap?. Equine Vet Educ 2019;31:151-153.
  41. DeLay J. Postmortem findings in Ontario racehorses, 2003-2015.. J Vet Diagn Invest 2017;29:457-464.

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