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Veterinary surgery : VS2019; 49 Suppl 1; O54-O59; doi: 10.1111/vsu.13264

Prospective randomized investigation of topical anesthesia during unilateral laparoscopic ovariectomy in horses.

Abstract: To compare pain-related responses in mares receiving topical or injected anesthesia of the ovarian pedicle prior to standing unilateral laparoscopic ovariectomy. Methods: Prospective randomized, blinded, placebo-controlled study. Methods: Fifteen healthy research mares. Methods: Mares were restrained in stocks and administered sedation. A right or left paralumbar ovariectomy was performed by using a laparoscopic portal and two instrument portals. Mares were divided into two treatment groups, and equal volumes of mepivacaine anesthesia were administered either topically (n = 8) or by injection into the ovarian pedicle (n = 7). Saline controls were simultaneously administered topically (n = 7) or by injection (n = 8), and surgeons were blinded to the treatment group. Ovarian removal was performed with traumatic forceps and a blunt tip vessel sealer and divider. Pain responses were measured by operative visual analog scale (VAS) scoring and perioperative serum cortisol response. Visual analog scale and serum cortisol were compared between groups by using Mann-Whitney testing. Serum cortisol concentrations were evaluated using repeated-measures one-way analysis of variance. Results: Ovaries were removed in all mares by using the described technique without operative complications. Quantity of sedation required to complete the procedure, operative VAS scores, and perioperative cortisol concentrations did not differ between treatment groups. Conclusions: Application of topical mepivacaine to the ovary provided intraoperative analgesia similar to injection of the ovarian pedicle when performing unilateral standing laparoscopic ovariectomy in mares. Conclusions: Topical anesthesia application to the ovary could provide an alternative to laparoscopic needle use, reducing the risk of inadvertent trauma to the pedicle or other visceral organs during laparoscopic ovariectomy.
© 2019 The American College of Veterinary Surgeons.
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Publication Date: 2019-06-21 PubMed ID: 31225655DOI: 10.1111/vsu.13264Google Scholar: Lookup
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  • Journal Article
  • Randomized Controlled Trial
  • Veterinary

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research is a comparative study on the differing effects of topical or injected anesthesia in mares during unilateral laparoscopic ovariectomy procedures. The study finds that both methods provide similar levels of analgesia, suggesting the potential for topical anesthesia as a safer alternative to injected anesthesia.

Methodology

  • The study is a prospective, randomized, blinded, and placebo-controlled research.
  • It involves fifteen healthy mares undergoing laparoscopic ovariectomy, where their ovaries were removed.
  • The mares were divided into two treatment groups, one receiving anesthesia topically and the other via injection into the ovarian pedicle.
  • In addition to the mepivacaine anesthesia, saline controls were also administered to each group, either topically or by injection.
  • During the procedures, the surgeons were unaware of the specific treatment each mare was receiving.

Procedure

  • The ovaries were removed using traumatic forceps and a blunt tip vessel sealer and divider, which was done via a laparoscopic portal with two instrument portals.
  • The level of pain experienced by the mares was estimated through operative visual analog scale (VAS) scoring and the evaluation of perioperative serum cortisol response.
  • The VAS scores and serum cortisol results were then compared between the two groups using Mann-Whitney testing methods.
  • Serum cortisol concentrations were further analysed using repeated-measures one-way analysis of variance.

Results and Conclusions

  • All the mares went through the procedure without any complications and the amount of sedation required, VAS scores and cortisol concentrations did not show any significant difference between the two groups.
  • The study thereby concludes that the application of topical mepivacaine provides a similar level of analgesia (pain relief) as its injection into the ovarian pedicle for unilateral standing laparoscopic ovariectomy in mares.
  • As a result, this research suggests that topical anesthesia might be a safer alternative. It could reduce the risk of unintended trauma to the ovarian pedicle or other visceral organs during laparoscopic ovariectomy by eliminating the need for needle use.

Cite This Article

APA
Koch DW, Easley JT, Hatzel JN, Nelson BB, Hendrickson DA, Bruemmer J, Hackett ES. (2019). Prospective randomized investigation of topical anesthesia during unilateral laparoscopic ovariectomy in horses. Vet Surg, 49 Suppl 1, O54-O59. https://doi.org/10.1111/vsu.13264

Publication

Veterinary surgery : VS
ISSN: 1532-950X
NlmUniqueID: 8113214
Country: United States
Language: English
Volume: 49 Suppl 1
Pages: O54-O59

Researcher Affiliations

Koch, Drew W
  • Department of Clinical Sciences, Colorado State University, Fort Collins, Colorado.
Easley, Jeremiah T
  • Department of Clinical Sciences, Colorado State University, Fort Collins, Colorado.
Hatzel, Jennifer N
  • Department of Clinical Sciences, Colorado State University, Fort Collins, Colorado.
Nelson, Brad B
  • Department of Clinical Sciences, Colorado State University, Fort Collins, Colorado.
Hendrickson, Dean A
  • Department of Clinical Sciences, Colorado State University, Fort Collins, Colorado.
Bruemmer, Jason
  • Department of Animal Sciences, Colorado State University, Fort Collins, Colorado.
Hackett, Eileen S
  • Department of Clinical Sciences, Colorado State University, Fort Collins, Colorado.

MeSH Terms

  • Anesthesia, Local / veterinary
  • Anesthetics, Local / administration & dosage
  • Anesthetics, Local / pharmacology
  • Animals
  • Female
  • Horses / surgery
  • Laparoscopy / methods
  • Laparoscopy / veterinary
  • Mepivacaine / administration & dosage
  • Mepivacaine / pharmacology
  • Ovariectomy / methods
  • Ovariectomy / veterinary
  • Ovary / surgery
  • Prospective Studies

Grant Funding

  • Center for Companion Animal Studies, Colorado State University.

References

This article includes 15 references
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Citations

This article has been cited 3 times.
  1. Straticò P, Guerri G, Palozzo A, Varasano V, Petrizzi L. Current Use of Equine Laparoscopy in Urogenital Disorders: A Scoping Review of the Literature from 2000 to 2021. Vet Sci 2022 Jan 22;9(2).
    doi: 10.3390/vetsci9020041pubmed: 35202295google scholar: lookup
  2. Vullo C, Tambella AM, Meligrana M, Catone G. Analgesic and Sedative Effects of Epidural Lidocaine-Xylazine in Elective Bilateral Laparoscopic Ovariectomy in Standing Mule Mares. Animals (Basel) 2021 Aug 17;11(8).
    doi: 10.3390/ani11082419pubmed: 34438877google scholar: lookup
  3. Giambrone G, Catone G, Marino G, Gugliandolo E, Miloro R, Vullo C. Loco-Regional Anaesthesia during Standing Laparoscopic Ovariectomy in Equids: A Systematic Review (2003-2023) of the Literature. Animals (Basel) 2024 Aug 8;14(16).
    doi: 10.3390/ani14162306pubmed: 39199841google scholar: lookup
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