Proteomic evaluation of milk from different mammalian species as a substitute for breast milk.
Abstract: As milk represents the main source of nutrition for infants, the question of an effective human milk substitute becomes mandatory when a formula-fed baby is allergic to cows' milk proteins. In this case, formulas containing extensively hydrolysed milk proteins should be preferred, but even such a formula may cause allergic reactions in highly sensitive patients. If there is evidence of cows' milk allergy with IgE-associated symptoms, after 6 mo of age, a soy bean formula may be recommended only when tolerance to soy protein has been established by clinical challenge. In infants with allergic reactions to cows' milk proteins, even after extensive hydrolyzation, proteomic techniques coupled to immunological methods may make it possible to select other milk products that do not contain the same allergens as ordinary cow's milk. In this paper, evidence will be presented that proteomic evaluation of proteins from different mammalian species may be a suitable method of testing whether proteins from the milk of different mammalian species may be used as a substitute for untreated bovine milk. Conclusions: Proteomic evaluation of milk from different mammalian species may not only be of help when recommending suitable feeding in cases of cows' milk allergy but also gives new insight into the background to allergic reactions caused by milk proteins.
Publication Date: 2006-01-20 PubMed ID: 16421029DOI: 10.1111/j.1651-2227.2005.tb01842.xGoogle Scholar: Lookup
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- Journal Article
Summary
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This research explores the use of milk from different mammals as a possible substitute for cow’s milk in cases where infants exhibit allergies to cow’s milk proteins. Through proteomic evaluations, the study seeks to identify milks that do not contain the same allergens found in cow’s milk.
Objective and Necessity of the Research
- The main goal of this research is to find an efficient substitute for human milk when infants manifest allergic responses to proteins found in cow’s milk, which is commonly used in formulas. When cases of cow’s milk allergy are verified, other sources of milk need to be considered. This study thus explores milk from other mammalian species to see if they can provide the essential nutrition without causing allergic reactions.
Methodology and Analysis
- Proteomic techniques, in combination with immunological methods, are employed for this research. These methods help in identifying and analyzing the proteins in milk from various mammals to ascertain if they contain the allergy-causing constituents found in cow’s milk.
- This proteomic evaluation is particularly crucial for infants who exhibit allergic reactions to cow’s milk proteins even after the formula has gone through extensive hydrolyzation – a process designed to break down proteins and thus decrease the potential for allergy.
- The suitability of milk proteins from different mammals is then tested through these evaluations.
Results and Conclusion
- The findings suggest that proteomic evaluation can aid in the selection of milk substitute for infants allergic to cow’s milk proteins. Milk from different mammals might not contain the same allergens and could, therefore, serve as effective alternatives.
- Moreover, this analysis also provides a better understanding of allergens present in different milk products and their role in instigating allergic reactions. Consequently, this research contributes new information to the ongoing studies on allergies to milk proteins.
Cite This Article
APA
D'Auria E, Agostoni C, Giovannini M, Riva E, Zetterström R, Fortin R, Greppi GF, Bonizzi L, Roncada P.
(2006).
Proteomic evaluation of milk from different mammalian species as a substitute for breast milk.
Acta Paediatr, 94(12), 1708-1713.
https://doi.org/10.1111/j.1651-2227.2005.tb01842.x Publication
Researcher Affiliations
- Department of Paediatrics, San Paolo Hospital, University of Milan, Milan, Italy.
MeSH Terms
- Animals
- Buffaloes / immunology
- Cattle / immunology
- Electrophoresis, Gel, Two-Dimensional
- Equidae / immunology
- Goats / immunology
- Horses / immunology
- Humans
- Hydrolysis
- Mammals / immunology
- Milk Proteins / analysis
- Milk, Human / immunology
- Proteomics
- Sheep / immunology
Citations
This article has been cited 15 times.- Agregán R, Echegaray N, López-Pedrouso M, Kharabsheh R, Franco D, Lorenzo JM. Proteomic Advances in Milk and Dairy Products.. Molecules 2021 Jun 23;26(13).
- KhalKhal E, Rezaei-Tavirani M, Rostamii-Nejad M. Pharmaceutical Advances and Proteomics Researches.. Iran J Pharm Res 2019 Fall;18(Suppl1):51-67.
- Faccia M, D'Alessandro AG, Summer A, Hailu Y. Milk Products from Minor Dairy Species: A Review.. Animals (Basel) 2020 Jul 24;10(8).
- Mansor M, Al-Obaidi JR, Jaafar NN, Ismail IH, Zakaria AF, Abidin MAZ, Selamat J, Radu S, Jambari NN. Optimization of Protein Extraction Method for 2DE Proteomics of Goat's Milk.. Molecules 2020 Jun 5;25(11).
- Bhat SA, Ahmad SM, Ibeagha-Awemu EM, Mobashir M, Dar MA, Mumtaz PT, Shah RA, Dar TA, Shabir N, Bhat HF, Ganai NA. Comparative milk proteome analysis of Kashmiri and Jersey cattle identifies differential expression of key proteins involved in immune system regulation and milk quality.. BMC Genomics 2020 Feb 14;21(1):161.
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