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Journal of equine science2016; 27(3); 125-129; doi: 10.1294/jes.27.125

Reference range of blood biomarkers for oxidative stress in Thoroughbred racehorses (2-5 years old).

Abstract: The oxidant and antioxidant equilibrium is known to play an important role in equine medicine and equine exercise physiology. There are abundant findings in this field; however, not many studies have been conducted for reference ranges of oxidative stress biomarkers in horses. This study was conducted to determine the reference values of reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) using blood samples from 372 (191 males, 181 females) Thoroughbred racehorse aged 2 to 5 (3.43 ± 1.10 (mean ± SD)) years old. There were obvious gender differences in oxidative biomarkers, and growth/age-related changes were observed especially in females. Gender and age must be considered when interpreting obtained oxidative stress biomarkers for diagnosis of disease or fitness alterations in Thoroughbred racehorses.
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Publication Date: 2016-09-30 PubMed ID: 27703408PubMed Central: PMC5048360DOI: 10.1294/jes.27.125Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research investigates levels of molecules related to oxidative stress in Thoroughbred racehorses, finding distinct differences based on gender and age. This suggests that these factors should be considered when using such biomarkers to diagnose disease or assess fitness in these horses.

Objective of the Study

  • The main objective of this study is to create a reference range for oxidative stress biomarkers in Thoroughbred racehorses, focusing on two specific molecules: reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP). This reference range would enhance the understanding of normal levels of these oxidative stress markers and improve diagnosing diseases or fitness alterations in horses.

Study Participants

  • The study included 372 Thoroughbred racehorses, aged between 2-5 years, comprising nearly an equal number of males (191) and females (181). The average age of the horses was approximately 3.43 years.

Procedure

  • The study collected blood samples from the participating horses and measured their d-ROMs and BAP levels. The d-ROMs represent the reactive oxygen substances produced by the body, while the BAP represents the body’s ability to neutralize these reactive substances.

Findings

  • The results indicate that there were significant differences in the levels of these oxidative biomarkers between male and female horses. It also found that there were noticeable age-related changes, especially in female horses.

Implications

  • The research shows that gender and age significantly affect the levels of oxidative stress biomarkers in Thoroughbred racehorses. The study implies that veterinarians and researchers should consider these factors when interpreting oxidative stress biomarker levels in diagnosing diseases or assessing fitness alterations in these horses.

Cite This Article

APA
Kusano K, Yamazaki M, Kiuchi M, Kaneko K, Koyama K. (2016). Reference range of blood biomarkers for oxidative stress in Thoroughbred racehorses (2-5 years old). J Equine Sci, 27(3), 125-129. https://doi.org/10.1294/jes.27.125

Publication

Journal of equine science
ISSN: 1340-3516
NlmUniqueID: 9503751
Country: Japan
Language: English
Volume: 27
Issue: 3
Pages: 125-129

Researcher Affiliations

Kusano, Kanichi
  • Miho Training Center, Racehorse Hospital, Japan Racing Association, Ibaraki 300-0493, Japan.
Yamazaki, Masahiko
  • Yamazaki Horse Clinic, Ibaraki 300-0415, Japan.
Kiuchi, Masataka
  • Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi 400-8510, Japan.
Kaneko, Kouki
  • Wismerll Company Limited, Tokyo 113-0033, Japan.
Koyama, Katsuhiro
  • Graduate School Department of Interdisciplinary Research, University of Yamanashi, Yamanashi 400-8510, Japan.

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Citations

This article has been cited 8 times.
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