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Home / Equine Research Bank / Vet Clin North Am Equine Pract / Regenerative Medicine and Rehabilitation for Tendinous and L...
The Veterinary clinics of North America. Equine practice2018; 34(2); 359-373; doi: 10.1016/j.cveq.2018.04.012

Regenerative Medicine and Rehabilitation for Tendinous and Ligamentous Injuries in Sport Horses.

Abstract: Tendon and ligament injuries are a common source of lameness in the athletic horse. Although tendons and ligaments have the ability to spontaneously heal, lesions tend to fill with biomechanically inferior fibrous tissue such that the horse is prone to reinjury. Regenerative medicine is used to improve quality of repair tissue and prevent reinjury. Platelet-rich plasma, stem cells, and autologous conditioned serum are the most commonly used orthobiologics in the horse. A tailored rehabilitation program is key to returning horses to athleticism following injury. The specifics of regenerative medicine and rehabilitation for tendonitis and desmitis in the horse are discussed.
Copyright © 2018 Elsevier Inc. All rights reserved.
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Publication Date: 2018-05-24 PubMed ID: 29803299DOI: 10.1016/j.cveq.2018.04.012Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research study reviews the use of regenerative medicine techniques and rehabilitation treatment plans for sports horses that experience common tendon and ligament injuries. The aim is to improve injury recovery quality and prevent recurrent injuries using treatments like platelet-rich plasma, stem cells, and autologous conditioned serum.

Tendon and Ligament Injuries in Sport Horses

  • Injuries to tendons and ligaments are cited as a significant cause of lameness in athletic horses. These structures play critical roles in the mobility and athletic performance of the horse, hence, their damage significantly impairs these activities.
  • Although natural healing processes do occur, the study points out that repair tissue often lacks sufficient biomechanical quality, which exaggerates the risk of recurrent injuries for the horses. The lesions tend to fill with inferior fibrous tissue during the healing process, making the area prone to reinjury.

Regenerative Medicine Intervention

  • The study highlights regenerative medicine as a useful intervention in improving the quality of repair tissue and reducing the risk of reinjury. This field of medicine aims to restore the function of damaged tissues by catalyzing the body’s own repair mechanism or by using engineered tissues and organs as treatment.
  • Specifically, three types of orthobiologics are commonly utilized in treating horses: platelet-rich plasma (PRP), stem cells, and autologous conditioned serum (ACS). These are substances found in the body that can help injuries heal more quickly. They promote the recovery process through different mechanisms such as promoting cell proliferation, differentiation, and regeneration.

Rehabilitation Post-Injury

  • Alongside regenerative medicine, an effective rehabilitation program is essential for a horse’s full recovery and return to athletic activities. The study states that a tailored program is necessary, recognizing the individual differences among horses and varied levels of injuries.
  • The program would commonly involve physiotherapy strategies to restore functionality, remedies to manage pain and inflammation, and in some cases restructuring of the training regime to prevent reinjury.

Tendonitis and Desmitis Treatment

  • The study specifically discusses the application of regenerative medicine and rehabilitation for tendonitis and desmitis, common issues in sport horses. Tendonitis is inflammation of a tendon, while desmitis is inflammation of a ligament. The study emphasizes that treatment for these conditions should enhance the healing process, restore function, and prevent reinjury.

Cite This Article

APA
Ortved KF. (2018). Regenerative Medicine and Rehabilitation for Tendinous and Ligamentous Injuries in Sport Horses. Vet Clin North Am Equine Pract, 34(2), 359-373. https://doi.org/10.1016/j.cveq.2018.04.012

Publication

The Veterinary clinics of North America. Equine practice
ISSN: 1558-4224
NlmUniqueID: 8511904
Country: United States
Language: English
Volume: 34
Issue: 2
Pages: 359-373

Researcher Affiliations

Ortved, Kyla F
  • Department of Clinical Studies, New Bolton Center, University of Pennsylvania, 382 West Street Road, Kennett Square, PA 19348, USA. Electronic address: kortved@vet.upenn.edu.

MeSH Terms

  • Animals
  • Horse Diseases / pathology
  • Horse Diseases / therapy
  • Horses / injuries
  • Ligaments / injuries
  • Regenerative Medicine
  • Sports
  • Tendinopathy / therapy
  • Tendinopathy / veterinary

Citations

This article has been cited 22 times.
  1. Carmona JU, López C, Argüelles D. Addressing Heterogeneity in Equine PRP Therapies: A Scoping Review of Methods, Evidence, and Commercial Validation. Animals (Basel) 2025 Dec 13;15(24).
    doi: 10.3390/ani15243586pubmed: 41463871google scholar: lookup
  2. Banu SA, Sharun K, Emmanuel RS, Mamachan M, Manjusha KM, Muthu S, El-Husseiny HM, Kumar R, Pawde AM, Dhama K, Amarpal. Stem Cell Exosomes for Osteoarthritis in Veterinary Medicine. Stem Cells Int 2025;2025:4888569.
    doi: 10.1155/sci/4888569pubmed: 40704321google scholar: lookup
  3. Xiongce L, Tao Y, Zhu J, Jin Y, Wang L. A bibliometric analysis from 2013 to 2023 reveals research hotspots and trends in the connection between sport and regenerative medicine. Medicine (Baltimore) 2024 Jul 5;103(27):e38846.
    doi: 10.1097/MD.0000000000038846pubmed: 38968451google scholar: lookup
  4. Reis IL, Lopes B, Sousa P, Sousa AC, Rêma A, Caseiro AR, Briote I, Rocha AM, Pereira JP, Mendonça CM, Santos JM, Lamas L, Atayde LM, Alvites RD, Maurício AC. Case report: Equine metacarpophalangeal joint partial and full thickness defects treated with allogenic equine synovial membrane mesenchymal stem/stromal cell combined with umbilical cord mesenchymal stem/stromal cell conditioned medium. Front Vet Sci 2024;11:1403174.
    doi: 10.3389/fvets.2024.1403174pubmed: 38840629google scholar: lookup
  5. Reis IL, Lopes B, Sousa P, Sousa AC, Caseiro AR, Mendonça CM, Santos JM, Atayde LM, Alvites RD, Maurício AC. Equine Musculoskeletal Pathologies: Clinical Approaches and Therapeutical Perspectives-A Review. Vet Sci 2024 Apr 26;11(5).
    doi: 10.3390/vetsci11050190pubmed: 38787162google scholar: lookup
  6. Leal Reis I, Lopes B, Sousa P, Sousa AC, Branquinho MV, Caseiro AR, Rêma A, Briote I, Mendonça CM, Santos JM, Atayde LM, Alvites RD, Maurício AC. Treatment of Equine Tarsus Long Medial Collateral Ligament Desmitis with Allogenic Synovial Membrane Mesenchymal Stem/Stromal Cells Enhanced by Umbilical Cord Mesenchymal Stem/Stromal Cell-Derived Conditioned Medium: Proof of Concept. Animals (Basel) 2024 Jan 24;14(3).
    doi: 10.3390/ani14030370pubmed: 38338013google scholar: lookup
  7. Tognoloni A, Bartolini D, Pepe M, Di Meo A, Porcellato I, Guidoni K, Galli F, Chiaradia E. Platelets Rich Plasma Increases Antioxidant Defenses of Tenocytes via Nrf2 Signal Pathway. Int J Mol Sci 2023 Aug 27;24(17).
    doi: 10.3390/ijms241713299pubmed: 37686103google scholar: lookup
  8. Leal Reis I, Lopes B, Sousa P, Sousa AC, Branquinho M, Caseiro AR, Pedrosa SS, Rêma A, Oliveira C, Porto B, Atayde L, Amorim I, Alvites R, Santos JM, Maurício AC. Allogenic Synovia-Derived Mesenchymal Stem Cells for Treatment of Equine Tendinopathies and Desmopathies-Proof of Concept. Animals (Basel) 2023 Apr 11;13(8).
    doi: 10.3390/ani13081312pubmed: 37106875google scholar: lookup
  9. Duddy HR, Schoonover MJ, Hague BA. Outcome following local injection of a liquid amnion allograft for treatment of equine tendonitis or desmitis - 100 cases. BMC Vet Res 2022 Nov 7;18(1):391.
    doi: 10.1186/s12917-022-03480-5pubmed: 36345002google scholar: lookup
  10. Cahalan SD, Boehm I, Jones RA, Piercy RJ. Recognising the potential of large animals for modelling neuromuscular junction physiology and disease. J Anat 2022 Nov;241(5):1120-1132.
    doi: 10.1111/joa.13749pubmed: 36056593google scholar: lookup
  11. Shojaee A, Ejeian F, Parham A, Nasr Esfahani MH. Optimizing Tenogenic Differentiation of Equine Adipose-Derived Mesenchymal Stem Cells (eq-ASC) Using TGFB3 Along with BMP Antagonists. Cell J 2022 Jul 27;24(7):370-379.
    doi: 10.22074/cellj.2022.7892pubmed: 36043405google scholar: lookup
  12. Jacobs CC, O'Neil E, Prange T. Efficacy of a commercial dry sleeve cryotherapy system for cooling the equine metacarpus. Vet Surg 2022 Oct;51(7):1070-1077.
    doi: 10.1111/vsu.13847pubmed: 35834384google scholar: lookup
  13. Knott LE, Fonseca-Martinez BA, O'Connor AM, Goodrich LR, McIlwraith CW, Colbath AC. Current use of biologic therapies for musculoskeletal disease: A survey of board-certified equine specialists. Vet Surg 2022 May;51(4):557-567.
    doi: 10.1111/vsu.13805pubmed: 35383972google scholar: lookup
  14. Prządka P, Buczak K, Frejlich E, Gąsior L, Suliga K, Kiełbowicz Z. The Role of Mesenchymal Stem Cells (MSCs) in Veterinary Medicine and Their Use in Musculoskeletal Disorders. Biomolecules 2021 Aug 2;11(8).
    doi: 10.3390/biom11081141pubmed: 34439807google scholar: lookup
  15. Montano C, Auletta L, Greco A, Costanza D, Coluccia P, Del Prete C, Meomartino L, Pasolini MP. The Use of Platelet-Rich Plasma for Treatment of Tenodesmic Lesions in Horses: A Systematic Review and Meta-Analysis of Clinical and Experimental Data. Animals (Basel) 2021 Mar 12;11(3).
    doi: 10.3390/ani11030793pubmed: 33809227google scholar: lookup
  16. King W, Cawood K, Bookmiller M. The Use of Autologous Protein Solution (Pro-Stride(®)) and Leukocyte-Rich Platelet-Rich Plasma (Restigen(®)) in Canine Medicine. Vet Med (Auckl) 2021;12:53-65.
    doi: 10.2147/VMRR.S286913pubmed: 33777723google scholar: lookup
  17. Bukowska J, Szóstek-Mioduchowska AZ, Kopcewicz M, Walendzik K, Machcińska S, Gawrońska-Kozak B. Adipose-Derived Stromal/Stem Cells from Large Animal Models: from Basic to Applied Science. Stem Cell Rev Rep 2021 Jun;17(3):719-738.
    doi: 10.1007/s12015-020-10049-ypubmed: 33025392google scholar: lookup
  18. Sukhikh S, Babich O, Prosekov A, Patyukov N, Ivanova S. Future of Chondroprotectors in the Treatment of Degenerative Processes of Connective Tissue. Pharmaceuticals (Basel) 2020 Aug 28;13(9).
    doi: 10.3390/ph13090220pubmed: 32872387google scholar: lookup
  19. Mund SJK, Kawamura E, Awang-Junaidi AH, Campbell J, Wobeser B, MacPhee DJ, Honaramooz A, Barber S. Homing and Engraftment of Intravenously Administered Equine Cord Blood-Derived Multipotent Mesenchymal Stromal Cells to Surgically Created Cutaneous Wound in Horses: A Pilot Project. Cells 2020 May 8;9(5).
    doi: 10.3390/cells9051162pubmed: 32397125google scholar: lookup
  20. Centeno CJ, Pastoriza SM. PAST, CURRENT AND FUTURE INTERVENTIONAL ORTHOBIOLOGICS TECHNIQUES AND HOW THEY RELATE TO REGENERATIVE REHABILITATION: A CLINICAL COMMENTARY. Int J Sports Phys Ther 2020 Apr;15(2):301-325.
    pubmed: 32269863
  21. Fuggle NR, Cooper C, Oreffo ROC, Price AJ, Kaux JF, Maheu E, Cutolo M, Honvo G, Conaghan PG, Berenbaum F, Branco J, Brandi ML, Cortet B, Veronese N, Kurth AA, Matijevic R, Roth R, Pelletier JP, Martel-Pelletier J, Vlaskovska M, Thomas T, Lems WF, Al-Daghri N, Bruyère O, Rizzoli R, Kanis JA, Reginster JY. Alternative and complementary therapies in osteoarthritis and cartilage repair. Aging Clin Exp Res 2020 Apr;32(4):547-560.
    doi: 10.1007/s40520-020-01515-1pubmed: 32170710google scholar: lookup
  22. Chung MJ, Park S, Son JY, Lee JY, Yun HH, Lee EJ, Lee EM, Cho GJ, Lee S, Park HS, Jeong KS. Differentiation of equine induced pluripotent stem cells into mesenchymal lineage for therapeutic use. Cell Cycle 2019 Nov;18(21):2954-2971.
    doi: 10.1080/15384101.2019.1664224pubmed: 31505996google scholar: lookup
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