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The Canadian veterinary journal = La revue veterinaire canadienne2023; 64(10); 957-967; doi: 10.1111/vsu.13506

Review of local extravascular delivery systems for chemotherapeutic agents in small animals and horses.

Abstract: Tumors of various sizes and locations can create a treatment dilemma in achieving adequate surgical margins when sufficient free tissue is not available for closure. Extravascular local adjunctive chemotherapy has been investigated clinically to aid in achieving local tumor control in animals with naturally occurring neoplastic disease. Local chemotherapy can be an alternative primary or a local adjunctive treatment. This is a summary of relevant findings of in vitro and in vivo studies on local chemotherapeutic delivery through carrier media, together with a summary of outcomes of clinical use of local delivery of chemotherapeutic agents in small animals and Equidae. Literature from 1990 to 2022 was evaluated via searches of PubMed, Google Scholar, and CAB Abstracts databases for studies of local extravascular delivery of chemotherapeutic agents and chemotherapeutic-impregnated delivery systems in research and clinical settings in veterinary medicine. Chemotherapeutic-impregnated calcium sulfate hemihydrate beads with carboplatin are currently favored for extravascular delivery and are associated with minimal wound complications. The ideal delivery system may vary depending on the chemotherapeutic agent used, commercial availability, targeted tumor type, and location. Future investigations might focus on the required dose, the rate of sustained release, and enhancing nodal uptake. Examen des systèmes d’administration extravasculaire locaux d’agents chimiothérapeutiques chez les petits animaux et les chevaux. Des tumeurs de tailles et emplacements différents peuvent créer un dilemme thérapeutique pour obtenir des marges chirurgicales adéquates lorsqu’il n’y a pas suffisamment de tissu libre disponible pour la fermeture. La chimiothérapie d’appoint extravasculaire locale a été étudiée cliniquement pour aider à obtenir une limitation locale de la tumeur chez les animaux atteints d’une maladie néoplasique naturelle. La chimiothérapie locale peut être une alternative primaire ou un traitement local d’appoint. Il s’agit d’un résumé des résultats pertinents d’études in vitro et in vivo sur l’administration locale de chimiothérapie par le biais de transporteurs, ainsi que d’un résumé des résultats de l’utilisation clinique de l’administration locale d’agents chimiothérapeutiques chez les petits animaux et les équidés. La littérature de 1990 à 2022 a été évaluée via des recherches dans les bases de données PubMed, Google Scholar et CAB Abstracts pour des études sur l’administration extravasculaire locale d’agents chimiothérapeutiques et de systèmes d’administration chimiothérapeutiques imprégnés dans des contextes de recherche et cliniques en médecine vétérinaire. Les billes de sulfate de calcium hémihydratée chimiothérapeutique imprégnées de carboplatine sont actuellement privilégiées pour l’administration extravasculaire et sont associées à des complications minimes des plaies. Le système d’administration idéal peut varier en fonction de l’agent chimiothérapeutique utilisé, de la disponibilité commerciale, du type de tumeur ciblé et de l’emplacement. Les recherches futures pourraient se concentrer sur la dose requise, le taux de libération prolongée et l’amélioration de l’absorption nodale.(Traduit par Dr Serge Messier).
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Publication Date: 2023-10-02 PubMed ID: 37780479PubMed Central: PMC10506355DOI: 10.1111/vsu.13506Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The article discusses the evaluation of local chemotherapeutic delivery systems in treating tumors in small animals and horses, with findings favoring the use of chemotherapeutic-impregnated calcium sulfate hemihydrate beads with carboplatin. The research encompasses literature from 1990 to 2022.

Objective

The research aims to review and analyze various studies on the use of local extravascular delivery methods of chemotherapy in veterinary medicine. It emphasizes the challenge of treating tumors where sufficient tissue for surgical closure is not available.

Methodology

  • The research encompasses an extensive literature review, ranging between 1990 to 2022.
  • Databases used for the research include PubMed, Google Scholar, and CAB Abstracts.
  • The paper reviews both laboratory and clinical studies that focus on the local extravascular delivery of chemotherapeutic agents and chemotherapeutic-impregnated delivery systems.

Findings

  • The chemotherapeutic-impregnated calcium sulfate hemihydrate beads combined with carboplatin is currently preferred for extravascular delivery.
  • Using these beads has been found to result in minimal wound complications.
  • Local chemotherapy can serve as a primary alternative treatment or a local adjunctive treatment to control the spread of tumors.

Variables

The ideal chemotherapeutic delivery system may vary depending on some factors such as:

  • The type of chemotherapeutic agent used.
  • The commercial availability of the treatment.
  • The type and location of the targeted tumor.

Future Research

Further investigations based on the study’s findings could focus on areas such as:

  • Determining the required dosage for treatments.
  • Enhancing the rate of the treatment’s sustained release.
  • Improving the nodal uptake of the treatments.

Cite This Article

APA
Risselada M, Worth DB. (2023). Review of local extravascular delivery systems for chemotherapeutic agents in small animals and horses. Can Vet J, 64(10), 957-967. https://doi.org/10.1111/vsu.13506

Publication

The Canadian veterinary journal = La revue veterinaire canadienne
ISSN: 0008-5286
NlmUniqueID: 0004653
Country: Canada
Language: English
Volume: 64
Issue: 10
Pages: 957-967

Researcher Affiliations

Risselada, Marije
  • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, 625 Harrison Street, West Lafayette, Indiana 47907, USA.
Worth, David B
  • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, 625 Harrison Street, West Lafayette, Indiana 47907, USA.

MeSH Terms

  • Animals
  • Horses
  • Carboplatin
  • Antineoplastic Agents / therapeutic use

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