Selection signatures for high altitude adaptation in livestock: A review.
Abstract: High altitude adapted livestock species (cattle, yak, goat, sheep, and horse) has critical role in the human socioeconomic sphere and acts as good source of animal source products including milk, meat, and leather, among other things. These species sustain production and reproduction even in harsh environments on account of adaptation resulting from continued evolution of beneficial traits. Selection pressure leads to various adaptive strategies in livestock whose footprints are evident at the different genomic sites as the "Selection Signature". Scrutiny of these signatures provides us crucial insight into the evolutionary process and domestication of livestock adapted to diverse climatic conditions. These signatures have the potential to change the sphere of animal breeding and further usher the selection programmes in right direction. Technological revolution and recent strides made in genomic studies has opened the routes for the identification of selection signatures. Numerous statistical approaches and bioinformatics tools have been developed to detect the selection signature. Consequently, studies across years have identified candidate genes under selection region found associated with numerous traits which have a say in adaptation to high-altitude environment. This makes it pertinent to have a better understanding about the selection signature, the ways to identify and how to utilize them for betterment of livestock populations as well as farmers. This review takes a closer look into the general concept, various methodologies, and bioinformatics tools commonly employed in selection signature studies and summarize the results of recent selection signature studies related to high-altitude adaptation in various livestock species. This review will serve as an informative and useful insight for researchers and students in the field of animal breeding and evolutionary biology.
Copyright © 2024 Elsevier B.V. All rights reserved.
Publication Date: 2024-07-08 PubMed ID: 38986751DOI: 10.1016/j.gene.2024.148757Google Scholar: Lookup
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Summary
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The research article discusses the adaptation of various livestock species to high altitude environments and how this evolutionary progress could potentially influence and improve animal breeding programs. The paper reviews the concept of a “selection signature”, a footprint of adaptive strategies in the genomes of these animals, and how its detection and understanding could benefit the livestock industry.
Overview of the Concept of Selection Signatures
- The article introduces the concept of “selection signatures,” which are footprints left in the genomes of livestock species due to selection pressure. These signatures are evident in various adaptive strategies these animal species develop to cope with harsh environmental conditions, like high altitudes.
- Understanding these selection signatures gives a crucial insight into the evolutionary processes and domestication of livestock adapted to diverse climatic conditions. It also has the potential to impact animal breeding and selection processes, directing them in a more targeted way.
The Importance of Technology in Identification of Selection Signatures
- The paper recognizes the role of technological advancement and genomic studies in identifying selection signatures. Various statistical approaches and bioinformatics tools have been developed to this end, helping researchers to reveal the patterns in animal genomes that represent adaptation and evolution.
- This evolution has been traced through various traits associated with high-altitude adaptation, highlighting the role of gene selection in developing these beneficial traits.
Relevance and Implication of the Study
- Acknowledging and understanding selection signatures is important for improving the livestock population and the livelihood of farmers. By understanding how animals have adapted to harsh conditions, it may be possible to guide breeding programs to replicate these beneficial traits.
- Through reviewing various methodologies and bioinformatics tools commonly employed in selection signature studies, this research aims to provide a comprehensive look at high-altitude adaptation in livestock species. The findings will provide a valuable insight for researchers and students in animal breeding and evolutionary biology fields.
Cite This Article
APA
Tiwari M, Gujar G, Shashank CG, Ponsuksili S.
(2024).
Selection signatures for high altitude adaptation in livestock: A review.
Gene, 927, 148757.
https://doi.org/10.1016/j.gene.2024.148757 Publication
Researcher Affiliations
- ICAR-National Dairy Research Institute, Karnal, India; U.P. Pt. Deen Dayal Upadhyaya Veterinary Science University and Cattle Research Institute, Mathura, India. Electronic address: bt.manish1@gmail.com.
- CVAS, Jodhpur, RAJUVAS, India.
- ICAR-National Dairy Research Institute, Karnal, India.
- Research Institute for Farm Animal Biology (FBN), Dummerstorf, Germany.
Conflict of Interest Statement
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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