FREE SHIPPING over $40
OVER 9000 FIVE-STAR REVIEWS
5% OFF ALL SUBSCRIPTIONS
100% HAPPINESS GUARANTEE
Analyze Diet
0
Home / Equine Research Bank / J Vet Intern Med / Sequential plasma lactate concentrations as prognostic indic...
Journal of veterinary internal medicine2009; 24(1); 198-205; doi: 10.1111/j.1939-1676.2009.0419.x

Sequential plasma lactate concentrations as prognostic indicators in adult equine emergencies.

Abstract: Sequential lactate concentration ([LAC]) measurements have prognostic value in that hospitalized humans and neonatal foals that have a delayed return to normolactatemia have greater morbidity and case fatality rate. Objective: Prognosis for survival is decreased in horses with a delayed return to normal [LAC]. Methods: Two hundred and fifty adult horses presented for emergency evaluation excepting horses evaluated because of only ophthalmologic conditions, superficial wounds, and septic synovitis without systemic involvement. Methods: Prospective observational study. [LAC] was measured at admission and then at 6, 12, 24, 48, and 72 hours after admission. The change in [LAC] over time ([LAC]deltaT) was calculated from changes in [LAC] between sampling points. Results: Median [LAC] was significantly (P < .001) higher at admission in nonsurvivors (4.10 mmol/L [range, 0.60-18.20 mmol/L]) when compared with survivors (1.30 mmol/L [range, 0.30-13.90 mmol/L]) and this difference remained at all subsequent time points. The odds ratio for nonsurvival increased from 1.29 (95% confidence interval 1.17-1.43) at admission to 49.90 (6.47-384) at 72 hours after admission for every 1 mmol/L increase in [LAC]. [LAC]deltaT was initially positive in all horses but became negative and significantly lower in nonsurvivors for the time periods between 24-72 hours (- 0.47, P = .001) and 48-72 hours (- 0.07, P = .032) when compared with survivors (0.00 at both time periods) consistent with lactate accumulation in nonsurvivors. Conclusions: These results indicate that lactate metabolism is impaired in critically ill horses and [LAC]deltaT can be a useful prognostic indicator in horses.
Get Full Text
Publication Date: 2009-11-21 PubMed ID: 19925572DOI: 10.1111/j.1939-1676.2009.0419.xGoogle Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
LinkedInCopy
  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research study investigates the correlation between sequential plasma lactate concentrations and prognostic indicators in adult equine emergencies. It discovers an impaired lactate metabolism in critically ill horses and establishes that lactate concentration measurements can be a useful prognostic indicator.

Overview of the Study

  • The research involved studying 250 horses that were presented for an emergency evaluation. Horses being evaluated for just ophthalmologic conditions, superficial wounds, and septic synovitis without systemic involvement were excluded.
  • This prospective observational study intended to track the connection between prognosis for survival and the amount of time taken for plasma lactate concentrations to return to normal levels in equine patients.

Methods of the Study

  • The researchers observed the difference between the lactate concentration at admission and then subsequently at 6, 12, 24, 48, and 72 hours after admission.
  • The alteration in the lactate concentration over time, technically noted as [LAC]deltaT, was calculated by querying the changes between the different sampling points.

Results of the Study

  • The findings highlighted that the plasma lactate concentration was significantly higher at admission in nonsurviving horses when compared to those that survived.
  • Furthermore, data showed that for every 1 mmol/L increase in lactate concentration, the odds ratio for non-survival rose significantly, particularly from admission to the 72 hours mark post-admission.
  • The change in lactate concentration over time was initially positive in all horses but exhibited a significant drop among the nonsurvivors between the 24 to 72-hour mark, as well as the 48 to 72-hour period, pointing towards lactate accumulation as a potential risk factor.

Conclusions of the Study

  • Consequently, the results suggest that critical illness in horses impairs lactate metabolism.
  • The study concludes the lactate concentration measurement over time can act as a valuable prognostic indicator in horses’ treatment, marking a potential path for improvement in veterinary care.

Cite This Article

APA
Tennent-Brown BS, Wilkins PA, Lindborg S, Russell G, Boston RC. (2009). Sequential plasma lactate concentrations as prognostic indicators in adult equine emergencies. J Vet Intern Med, 24(1), 198-205. https://doi.org/10.1111/j.1939-1676.2009.0419.x

Publication

Journal of veterinary internal medicine
ISSN: 0891-6640
NlmUniqueID: 8708660
Country: United States
Language: English
Volume: 24
Issue: 1
Pages: 198-205

Researcher Affiliations

Tennent-Brown, B S
  • Section of Medicine, Department of Clinical Studies-New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA, USA.
Wilkins, P A
    Lindborg, S
      Russell, G
        Boston, R C

          MeSH Terms

          • Animals
          • Anticoagulants
          • Blood Specimen Collection
          • Emergencies / veterinary
          • Female
          • Horse Diseases / pathology
          • Horses
          • Lactic Acid / blood
          • Male
          • Predictive Value of Tests
          • Sodium Fluoride

          Citations

          This article has been cited 18 times.
          1. Hardefeldt L, Thomas K, Page S, Norris J, Browning G, El Hage C, Stewart A, Gilkerson J, Muscatello G, Verwilghen D, van Galen G, Bauquier J, Cuming R, Reynolds B, Whittaker C, Wilkes E, Clulow J, Burden C, Begg L. Antimicrobial prescribing guidelines for horses in Australia. Aust Vet J 2025 Dec;103(12):781-889.
            doi: 10.1111/avj.70003pubmed: 40903020google scholar: lookup
          2. Mickevičienė I, Mikalauskienė D, Miknienė Z. The prognostic importance of physiological and biochemical parameters in horses afflicted with colic. Open Vet J 2024 Aug;14(8):1801-1807.
            doi: 10.5455/OVJ.2024.v14.i8.8pubmed: 39308735google scholar: lookup
          3. Rapezzano G, Marcatili M, Stephenson R, Pereira R, Hallowell G, Duz M. Evaluation of peritoneal l-lactate concentration in horses in the early post-partum period. Vet Med Sci 2024 May;10(3):e1352.
            doi: 10.1002/vms3.1352pubmed: 38634206google scholar: lookup
          4. Casalta H, Bayrou C, Djebala S, Eppe J, Gille L, Gommeren K, Marduel E, Sartelet A, Seys C, Versyp J, Grulke S. Evaluation of Blood Lactate, Heart Rate, Blood Pressure, and Shock Index, and Their Association with Prognosis in Calves. Vet Sci 2024 Jan 20;11(1).
            doi: 10.3390/vetsci11010045pubmed: 38275927google scholar: lookup
          5. Giraldo AF, Carballo R, Serrenho RC, Tran V, Valverde A, Renaud DL, Gomez DE. Association of the type of metabolic acidosis and non-survival of horses with colitis. Can Vet J 2023 Nov;64(11):1044-1050.
            pubmed: 37915775
          6. Martín-Cuervo M, Gracia-Calvo LA, Macías-García B, Ezquerra LJ, Barrera R. Evaluation of Eosinopenia as a SIRS Biomarker in Critically Ill Horses. Animals (Basel) 2022 Dec 15;12(24).
            doi: 10.3390/ani12243547pubmed: 36552467google scholar: lookup
          7. Smanik LE, Moser DK, Rothers KP, Hackett ES. Serial venous lactate measurement following gastrointestinal surgery in horses. J Vet Sci 2022 Sep;23(5):e66.
            doi: 10.4142/jvs.22038pubmed: 36038187google scholar: lookup
          8. Stefanovski D, Wilkins PA, Boston RC. Modeling Challenge Data to Quantify Endogenous Lactate Production. Front Endocrinol (Lausanne) 2021;12:656054.
            doi: 10.3389/fendo.2021.656054pubmed: 34267726google scholar: lookup
          9. Valverde A. Fluid Resuscitation for Refractory Hypotension. Front Vet Sci 2021;8:621696.
            doi: 10.3389/fvets.2021.621696pubmed: 33778035google scholar: lookup
          10. Witkowska-Piłaszewicz O, Cywińska A, Michlik-Połczyńska K, Czopowicz M, Strzelec K, Biazik A, Parzeniecka-Jaworska M, Crisman M, Witkowski L. Variations in haematological and biochemical parameters in healthy ponies. BMC Vet Res 2021 Jan 19;17(1):38.
            doi: 10.1186/s12917-020-02741-5pubmed: 33468115google scholar: lookup
          11. Di Lorenzo E, Rossi R, Ferrari F, Martini V, Comazzi S. Blood L-Lactate Concentration as an Indicator of Outcome in Roe Deer (Capreolus capreolus) Admitted to a Wildlife Rescue Center. Animals (Basel) 2020 Jun 20;10(6).
            doi: 10.3390/ani10061066pubmed: 32575686google scholar: lookup
          12. DeNotta SL, Divers TJ. Clinical Pathology in the Adult Sick Horse: The Gastrointestinal System and Liver. Vet Clin North Am Equine Pract 2020 Apr;36(1):105-120.
            doi: 10.1016/j.cveq.2019.11.004pubmed: 31982231google scholar: lookup
          13. Orr KE, Baker WT, Lynch TM, Hughes FE, Clark CK, Slone DE Jr, Fogle CA, Gonzalez LM. Prognostic value of colonic and peripheral venous lactate measurements in horses with large colon volvulus. Vet Surg 2020 Apr;49(3):472-479.
            doi: 10.1111/vsu.13361pubmed: 31916608google scholar: lookup
          14. Cole GC, Tordiffe ASW, Steenkamp G. Assessment of a portable lactate meter for field use in the white rhinoceros (Ceratotherium simum). Onderstepoort J Vet Res 2017 Nov 10;84(1):e1-e10.
            doi: 10.4102/ojvr.v84i1.1399pubmed: 29227129google scholar: lookup
          15. Trefz FM, Lorenz I, Lorch A, Constable PD. Clinical signs, profound acidemia, hypoglycemia, and hypernatremia are predictive of mortality in 1,400 critically ill neonatal calves with diarrhea. PLoS One 2017;12(8):e0182938.
            doi: 10.1371/journal.pone.0182938pubmed: 28817693google scholar: lookup
          16. Roy MF, Kwong GP, Lambert J, Massie S, Lockhart S. Prognostic Value and Development of a Scoring System in Horses With Systemic Inflammatory Response Syndrome. J Vet Intern Med 2017 Mar;31(2):582-592.
            doi: 10.1111/jvim.14670pubmed: 28207163google scholar: lookup
          17. Mizen K, Woodman J, Boysen SR, Wagg C, Greco-Otto P, Léguillette R, Roy MF. Effect of Dexamethasone on Resting Blood Lactate Concentrations in Horses. J Vet Intern Med 2017 Jan;31(1):164-169.
            doi: 10.1111/jvim.14630pubmed: 28019037google scholar: lookup
          18. Buczinski S, Boulay G, Francoz D. Preoperative and postoperative L-lactatemia assessment for the prognosis of right abomasal disorders in dairy cattle. J Vet Intern Med 2015 Jan;29(1):375-80.
            doi: 10.1111/jvim.12490pubmed: 25307271google scholar: lookup
          Subscribe to our newsletter
          Join 99,359 horse owners like you who receive our email updates on horse health and nutrition.