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Home / Equine Research Bank / Can Vet J / Seroprevalence of Cache Valley virus and related viruses in ...
The Canadian veterinary journal = La revue veterinaire canadienne2018; 59(4); 413-418;

Seroprevalence of Cache Valley virus and related viruses in sheep and other livestock from Saskatchewan, Canada.

Abstract: Cache Valley virus, an orthobunyavirus, is an important cause of ovine neonatal malformations. Information on the seroprevalence of this virus in Saskatchewan livestock populations is lacking. The objectives of this study were to determine the seroprevalence of Cache Valley virus and closely related viruses in sheep, cattle, goats, horses, and mule deer in Saskatchewan by performing a plaque-reduction neutralization test using Cache Valley virus. In total, sera from 130 sheep from 50 flocks were tested. Seroprevalence in sheep was 64.6% (84/130) and 94.0% (47/50) of flocks had 1 or more seropositive sheep. Antibodies to Cache Valley virus or closely related viruses were also detected in serum samples collected from cattle, goats, horses, and mule deer with seroprevalences of 20.0% (5/25), 33.3% (8/24), 69.0% (40/58), and 50.8% (33/65), respectively. These results suggest widespread exposure to Cache Valley virus or closely related viruses in domestic animals and mule deer in Saskatchewan. Le virus de la Vallée Cache, un orthobunyavirus, est une cause importante de malformations néonatales ovines. Il manque des renseignements sur la séroprévalence de ce virus dans les populations des cheptels de la Saskatchewan. Les objectifs de cette étude consistaient à déterminer la séroprévalence du virus de la Vallée Cache et des virus étroitement apparentés chez les moutons, les bovins, les chèvres, les chevaux et les cerfs mulets en Saskatchewan en réalisant un test de séro-neutralisation par réduction des plages en utilisant le virus de la Vallée Cache. Au total, le sérum provenant de 130 moutons dans 50 troupeaux a été testé. Chez les moutons, la séroprévalence était de 64,6 % (84/130) et 94,0 % (47/50) des troupeaux avaient un mouton ou plusieurs moutons séropositifs. Les anticorps pour le virus de la Vallée Cache ou les virus étroitement apparentés ont aussi été détectés dans les échantillons de sérum prélevés auprès des bovins, des chèvres, des chevaux et des cerfs mulets avec une séroprévalence de 20,0 % (5/25), de 33,3 % (8/24), de 69,0 % (40/58) et de 50,8 % (33/65), respectivement. Ces résultats suggèrent une vaste exposition au virus de la Vallée Cache ou à des virus étroitement apparentés chez les animaux domestiques et les cerfs mulets en Saskatchewan.(Traduit par Isabelle Vallières).
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Publication Date: 2018-04-03 PubMed ID: 29606729PubMed Central: PMC5855288
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The researchers conducted a study to understand the prevalence of the Cache Valley virus, associated with ovine neonatal malformations, in various livestock in Saskatchewan, Canada. Broad exposure to the virus or closely related variants was observed across different types of animals, including sheep, cattle, goats, horses, and mule deer.

Study Objectives and Methodology

  • The primary objective of the study was to determine the seroprevalence, or the presence of specific antibodies in the blood, of the Cache Valley virus and related viruses within various kinds of livestock – sheep, cattle, goats, horses, and mule deer – in Saskatchewan.
  • To achieve this, the researchers carried out a plaque-reduction neutralization test using the Cache Valley virus. This type of test is used to measure the ability of the specific antibodies in the serum to inhibit virus growth.
  • The researchers collected serum samples from a total of 130 sheep across 50 flocks for the investigation.

Findings of the Study

  • The seroprevalence in sheep was found to be significant, with 64.6% of the sheep (84 out of 130) and 94% of the flocks (47 out of 50) having one or more seropositive sheep.
  • The investigation also detected antibodies to the Cache Valley virus or related viruses in serum samples collected from other livestock populations. The seroprevalences in cattle, goats, horses, and mule deer were 20.0% (5 out of 25), 33.3% (8 out of 24), 69.0% (40 out of 58), and 50.8% (33 out of 65), respectively.

Conclusion

  • The results of the study suggest a widespread exposure to Cache Valley virus or its closely related viruses in domestic animals and mule deer in Saskatchewan.
  • The significant level of seroprevalence underlines the need for further research to understand the potential health and economic impacts on livestock in Saskatchewan and the need for developing preventive measures.

Cite This Article

APA
Uehlinger FD, Wilkins W, Godson DL, Drebot MA. (2018). Seroprevalence of Cache Valley virus and related viruses in sheep and other livestock from Saskatchewan, Canada. Can Vet J, 59(4), 413-418.

Publication

The Canadian veterinary journal = La revue veterinaire canadienne
ISSN: 0008-5286
NlmUniqueID: 0004653
Country: Canada
Language: English
Volume: 59
Issue: 4
Pages: 413-418

Researcher Affiliations

Uehlinger, Fabienne D
  • Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon S7N 5B4, Saskatchewan (Uehlinger); Government of Saskatchewan, Ministry of Agriculture Livestock Branch, 3085 Albert Street, Regina, Saskatchewan S4S 0B1 (Wilkins); Prairie Diagnostic Services, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Godson); Zoonotic Diseases and Special Pathogens Division, National Disease Laboratory, Public Health Agency of Canada, 1050 Arlington Street, Winnipeg, Manitoba R3E 3R2 (Drebot).
Wilkins, Wendy
  • Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon S7N 5B4, Saskatchewan (Uehlinger); Government of Saskatchewan, Ministry of Agriculture Livestock Branch, 3085 Albert Street, Regina, Saskatchewan S4S 0B1 (Wilkins); Prairie Diagnostic Services, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Godson); Zoonotic Diseases and Special Pathogens Division, National Disease Laboratory, Public Health Agency of Canada, 1050 Arlington Street, Winnipeg, Manitoba R3E 3R2 (Drebot).
Godson, Dale L
  • Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon S7N 5B4, Saskatchewan (Uehlinger); Government of Saskatchewan, Ministry of Agriculture Livestock Branch, 3085 Albert Street, Regina, Saskatchewan S4S 0B1 (Wilkins); Prairie Diagnostic Services, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Godson); Zoonotic Diseases and Special Pathogens Division, National Disease Laboratory, Public Health Agency of Canada, 1050 Arlington Street, Winnipeg, Manitoba R3E 3R2 (Drebot).
Drebot, Michael A
  • Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon S7N 5B4, Saskatchewan (Uehlinger); Government of Saskatchewan, Ministry of Agriculture Livestock Branch, 3085 Albert Street, Regina, Saskatchewan S4S 0B1 (Wilkins); Prairie Diagnostic Services, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Godson); Zoonotic Diseases and Special Pathogens Division, National Disease Laboratory, Public Health Agency of Canada, 1050 Arlington Street, Winnipeg, Manitoba R3E 3R2 (Drebot).

MeSH Terms

  • Animals
  • Antibodies, Viral / blood
  • Bunyamwera virus / immunology
  • Bunyaviridae Infections / epidemiology
  • Bunyaviridae Infections / immunology
  • Bunyaviridae Infections / veterinary
  • Cattle
  • Deer
  • Goats
  • Horses
  • Livestock
  • Neutralization Tests / veterinary
  • Saskatchewan / epidemiology
  • Seroepidemiologic Studies
  • Sheep
  • Sheep Diseases / epidemiology
  • Sheep Diseases / virology

References

This article includes 35 references
  1. HOLDEN P, HESS AD. Cache Valley virus, a previously undescribed mosquito-borne agent.. Science 1959 Oct 30;130(3383):1187-8.
    pubmed: 14402567doi: 10.1126/science.130.3383.1187google scholar: lookup
  2. Tauro LB, Almeida FL, Contigiani MS. First detection of human infection by Cache Valley and Kairi viruses (Orthobunyavirus) in Argentina.. Trans R Soc Trop Med Hyg 2009 Feb;103(2):197-9.
    pubmed: 18930511doi: 10.1016/j.trstmh.2008.09.004google scholar: lookup
  3. Drebot MA. Emerging mosquito-borne bunyaviruses in Canada.. Can Commun Dis Rep 2015 Jun 4;41(6):117-123.
    pmc: PMC5864308pubmed: 29769943doi: 10.14745/ccdr.v41i06a01google scholar: lookup
  4. Meyers MT, Bahnson CS, Hanlon M, Kopral C, Srisinlapaudom S, Cochrane ZN, Sabas CE, Saiyasombat R, Burrough ER, Plummer PJ, O'Connor AM, Marshall KL, Blitvich BJ. Management Factors Associated with Operation-Level Prevalence of Antibodies to Cache Valley Virus and Other Bunyamwera Serogroup Viruses in Sheep in the United States.. Vector Borne Zoonotic Dis 2015 Nov;15(11):683-93.
    pubmed: 26565774doi: 10.1089/vbz.2015.1810google scholar: lookup
  5. Campbell GL, Mataczynski JD, Reisdorf ES, Powell JW, Martin DA, Lambert AJ, Haupt TE, Davis JP, Lanciotti RS. Second human case of Cache Valley virus disease.. Emerg Infect Dis 2006 May;12(5):854-6.
    pmc: PMC3374447pubmed: 16704854doi: 10.3201/eid1205.051625google scholar: lookup
  6. Buescher EL, Byrne RJ, Clarke GC, Gould DJ, Russell PK, Scheider FG, Yuill TM. Cache Valley virus in the Del Mar Va Peninsula. I. Virologic and serologic evidence of infection.. Am J Trop Med Hyg 1970 May;19(3):493-502.
    pubmed: 4392807doi: 10.4269/ajtmh.1970.19.493google scholar: lookup
  7. Blitvich BJ, Saiyasombat R, Talavera-Aguilar LG, Garcia-Rejon JE, Farfan-Ale JA, Machain-Williams C, Loroño-Pino MA. Orthobunyavirus antibodies in humans, Yucatan Peninsula, Mexico.. Emerg Infect Dis 2012 Oct;18(10):1629-32.
    pmc: PMC3471633pubmed: 23017592doi: 10.3201/eid1810.120492google scholar: lookup
  8. Dimitrova K, Andonova M, Makowski K. Preliminary evidence of Cache Valley virus infections and associated human illness in western Canada in 2009. Can J Infect Dis Med Microbiol 2011;22:15A.
    pubmed: 0
  9. Sexton DJ, Rollin PE, Breitschwerdt EB, Corey GR, Myers SA, Dumais MR, Bowen MD, Goldsmith CS, Zaki SR, Nichol ST, Peters CJ, Ksiazek TG. Life-threatening Cache Valley virus infection.. N Engl J Med 1997 Feb 20;336(8):547-9.
    pubmed: 9023091doi: 10.1056/nejm199702203360804google scholar: lookup
  10. Nguyen NL, Zhao G, Hull R, Shelly MA, Wong SJ, Wu G, St George K, Wang D, Menegus MA. Cache valley virus in a patient diagnosed with aseptic meningitis.. J Clin Microbiol 2013 Jun;51(6):1966-9.
    pmc: PMC3716113pubmed: 23515536doi: 10.1128/jcm.00252-13google scholar: lookup
  11. Edwards JF, Livingston CW, Chung SI, Collisson EC. Ovine arthrogryposis and central nervous system malformations associated with in utero Cache Valley virus infection: spontaneous disease.. Vet Pathol 1989 Jan;26(1):33-9.
    pubmed: 2492399doi: 10.1177/030098588902600106google scholar: lookup
  12. McConnell S, Livingston C Jr, Calisher CH, Crandell RA. Isolations of Cache Valley virus in Texas, 1981.. Vet Microbiol 1987 Jan;13(1):11-8.
    pubmed: 3101276doi: 10.1016/0378-1135(87)90093-9google scholar: lookup
  13. Johnson GD, Bahnson CS, Ishii P, Cochrane ZN, Hokit DG, Plummer PJ, Bartholomay LC, Blitvich BJ. Monitoring sheep and Culicoides midges in Montana for evidence of Bunyamwera serogroup virus infection.. Vet Rec Open 2014;1(1):e000071.
    pmc: PMC4562451pubmed: 26392881doi: 10.1136/vetreco-2014-000071google scholar: lookup
  14. Chung SI, Livingston CW Jr, Jones CW, Collisson EW. Cache Valley virus infection in Texas sheep flocks.. J Am Vet Med Assoc 1991 Aug 1;199(3):337-40.
    pubmed: 1917638
  15. Burton AN, McLintock J, Francy DB. Isolation of St. Louis encephalitis and Cache Valley viruses from Saskatchewan mosquitoes.. Can J Public Health 1973 Jul-Aug;64(4):368-73.
    pubmed: 4147200
  16. Pabbaraju K, Ho KC, Wong S, Fox JD, Kaplen B, Tyler S, Drebot M, Tilley PA. Surveillance of mosquito-borne viruses in Alberta using reverse transcription polymerase chain reaction with generic primers.. J Med Entomol 2009 May;46(3):640-8.
    pubmed: 19496438doi: 10.1603/033.046.0332google scholar: lookup
  17. Thorsen J, Artsob H, Spence L, Surgeoner G, Helson B, Wright R. Virus isolations from mosquitoes in southern Ontario, 1976 and 1977.. Can J Microbiol 1980 Apr;26(4):436-40.
    pubmed: 6103747doi: 10.1139/m80-072google scholar: lookup
  18. Makowski K, Dimitrova K, Andonova M. The identification of probable cases of California serogroup virus infections in Manitoba in 2010. Can J Infect Dis Med Microbiol 2011;22:15A–16A.
    pubmed: 0
  19. Kulkarni MA, Berrang-Ford L, Buck PA, Drebot MA, Lindsay LR, Ogden NH. Major emerging vector-borne zoonotic diseases of public health importance in Canada.. Emerg Microbes Infect 2015 Jun 10;4(6):e33.
    pmc: PMC4773043pubmed: 26954882doi: 10.1038/emi.2015.33google scholar: lookup
  20. Shapiro J, Brooks A, Menzies P. Cache Valley virus identified as a cause of malformed lambs in Ontario. AHL Newsl 2012;16:15.
  21. Côté G, Fournier D, Leboeuf A. Cas de malformations congénitales chez des ovins causées par le virus de la vallée cache (birth defect cases in sheep caused by Cache Valley virus). MAPAQ; QC, Canada: 2013.
  22. Jansen J, Spinato M, Menzies P. Cache Valley virus — A cause of birth defects in Ontario lambs. 2016.
  23. Heinrichs R, Wilkins W, Schroeder G, Campbell J. Prevalence of Maedi-visna in Saskatchewan sheep.. Can Vet J 2017 Feb;58(2):183-186.
    pmc: PMC5234319pubmed: 28216689
  24. Beaty BJ, Calisher CH, Shope RS. Diagnostic procedures for viral, rickettsial and chlamydial infections. Washington, USA: Am Public Health Assoc; 1989. pp. 797–856.
  25. Blitvich BJ, Saiyasombat R, Travassos da Rosa A, Tesh RB, Calisher CH, Garcia-Rejon JE, Farfán-Ale JA, Loroño RE, Bates A, Loroño-Pino MA. Orthobunyaviruses, a common cause of infection of livestock in the Yucatan peninsula of Mexico.. Am J Trop Med Hyg 2012 Dec;87(6):1132-9.
    pmc: PMC3516088pubmed: 23045250doi: 10.4269/ajtmh.2012.12-0188google scholar: lookup
  26. Sahu SP, Pedersen DD, Ridpath HD, Ostlund EN, Schmitt BJ, Alstad DA. Serologic survey of cattle in the northeastern and north central United States, Virginia, Alaska, and Hawaii for antibodies to Cache Valley and antigenically related viruses (Bunyamwera serogroup virus).. Am J Trop Med Hyg 2002 Jul;67(1):119-22.
    pubmed: 12363055doi: 10.4269/ajtmh.2002.67.119google scholar: lookup
  27. McLean RG, Calisher CH, Parham GL. Isolation of Cache Valley virus and detection of antibody for selected arboviruses in Michigan horses in 1980.. Am J Vet Res 1987 Jul;48(7):1039-41.
    pubmed: 3631684
  28. Calisher CH, Francy DB, Smith GC, Muth DJ, Lazuick JS, Karabatsos N, Jakob WL, McLean RG. Distribution of Bunyamwera serogroup viruses in North America, 1956-1984.. Am J Trop Med Hyg 1986 Mar;35(2):429-43.
    pubmed: 2869708doi: 10.4269/ajtmh.1986.35.429google scholar: lookup
  29. Iversen JO, Wagner RJ, Leung MK, Hayles LB, McLintock JR. Cache Valley virus: isolations from mosquitoes in Saskatchewan, 1972-1974.. Can J Microbiol 1979 Jun;25(6):760-4.
    pubmed: 38897doi: 10.1139/m79-110google scholar: lookup
  30. Goff G, Whitney H, Drebot MA. Roles of host species, geographic separation, and isolation in the seroprevalence of Jamestown Canyon and snowshoe hare viruses in Newfoundland.. Appl Environ Microbiol 2012 Sep;78(18):6734-40.
    pmc: PMC3426688pubmed: 22798366doi: 10.1128/aem.01351-12google scholar: lookup
  31. Calisher CH, Sever JL. Are North American Bunyamwera serogroup viruses etiologic agents of human congenital defects of the central nervous system?. Emerg Infect Dis 1995 Oct-Dec;1(4):147-51.
    pmc: PMC2626893pubmed: 8903187doi: 10.3201/eid0104.950409google scholar: lookup
  32. Campbell GL, Eldridge BF, Hardy JL, Reeves WC, Jessup DA, Presser SB. Prevalence of neutralizing antibodies against California and Bunyamwera serogroup viruses in deer from mountainous areas of California.. Am J Trop Med Hyg 1989 Apr;40(4):428-37.
    pubmed: 2496610doi: 10.4269/ajtmh.1989.40.428google scholar: lookup
  33. Neitzel DF, Grimstad PR. Serological evidence of California group and Cache Valley virus infection in Minnesota white-tailed deer.. J Wildl Dis 1991 Apr;27(2):230-7.
    pubmed: 1906113doi: 10.7589/0090-3558-27.2.230google scholar: lookup
  34. Andreadis TG, Armstrong PM, Anderson JF, Main AJ. Spatial-temporal analysis of Cache Valley virus (Bunyaviridae: Orthobunyavirus) infection in anopheline and culicine mosquitoes (Diptera: Culicidae) in the northeastern United States, 1997-2012.. Vector Borne Zoonotic Dis 2014 Oct;14(10):763-73.
    pmc: PMC4208611pubmed: 25325321doi: 10.1089/vbz.2014.1669google scholar: lookup
  35. Hall RR, McKiel JA, Brown JH. Isolation of Turlock virus and a member of the Bunyamwera group, probably Cache Valley virus, from Alberta mosquitoes.. Can J Public Health 1968 Apr;59(4):159-60.
    pubmed: 4385087

Citations

This article has been cited 10 times.
  1. Bergevin MD, Ng V, Menzies P, Ludwig A, Mubareka S, Clow KM. Cache a Killer: Cache Valley virus seropositivity and associated farm management risk factors in sheep in Ontario, Canada. PLoS One 2023;18(8):e0290443.
    doi: 10.1371/journal.pone.0290443pubmed: 37616323google scholar: lookup
  2. Ayers VB, Huang YS, Kohl A, Dunlop JI, Hettenbach SM, Park SL, Higgs S, Vanlandingham DL. Comparison of Immunogenicity Between a Candidate Live Attenuated Vaccine and an Inactivated Vaccine for Cache Valley Virus. Viral Immunol 2023 Jan;36(1):41-47.
    doi: 10.1089/vim.2022.0103pubmed: 36622942google scholar: lookup
  3. Dieme C, Maffei JG, Diarra M, Koetzner CA, Kuo L, Ngo KA, Dupuis Ii AP, Zink SD, Backenson PB, Kramer LD, Ciota AT. Aedes Albopictus and Cache Valley virus: a new threat for virus transmission in New York State. Emerg Microbes Infect 2022 Dec;11(1):741-748.
    doi: 10.1080/22221751.2022.2044733pubmed: 35179429google scholar: lookup
  4. Skinner B, Mikula S, Davis BS, Powers JA, Hughes HR, Calvert AE. Monoclonal antibodies to Cache Valley virus for serological diagnosis. PLoS Negl Trop Dis 2022 Jan;16(1):e0010156.
    doi: 10.1371/journal.pntd.0010156pubmed: 35073325google scholar: lookup
  5. López K, Wilson SN, Coutermash-Ott S, Tanelus M, Stone WB, Porier DL, Auguste DI, Muller JA, Allicock OM, Paulson SL, Erasmus JH, Auguste AJ. Novel murine models for studying Cache Valley virus pathogenesis and in utero transmission. Emerg Microbes Infect 2021 Dec;10(1):1649-1659.
    doi: 10.1080/22221751.2021.1965497pubmed: 34353229google scholar: lookup
  6. Ludwig A, Zheng H, Vrbova L, Drebot MA, Iranpour M, Lindsay LR. Increased risk of endemic mosquito-borne diseases in Canada due to climate change. Can Commun Dis Rep 2019 Apr 4;45(4):91-97.
    doi: 10.14745/ccdr.v45i04a03pubmed: 31285698google scholar: lookup
  7. Waddell L, Pachal N, Mascarenhas M, Greig J, Harding S, Young I, Wilhelm B. Cache Valley virus: A scoping review of the global evidence. Zoonoses Public Health 2019 Nov;66(7):739-758.
    doi: 10.1111/zph.12621pubmed: 31254324google scholar: lookup
  8. Şevik M. A six-year epidemiological study of selected zoonotic abortifacient agents in ovine and caprine foetuses in Türkiye. Epidemiol Infect 2024 Dec 19;152:e173.
    doi: 10.1017/S0950268824001699pubmed: 39696935google scholar: lookup
  9. Goodman C, Powers JA, Mikula SR, Hughes HR, Biggerstaff BJ, Fitzpatrick K, Panella AJ, Machain-Williams C, Lee S, Calvert AE. Development of a Diagnostic IgM Antibody Capture ELISA for Detection of Anti-Cache Valley Virus Human IgM. Am J Trop Med Hyg 2025 Feb 5;112(2):386-395.
    doi: 10.4269/ajtmh.24-0360pubmed: 39561397google scholar: lookup
  10. Muller JA, López K, Escobar LE, Auguste AJ. Ecology and geography of Cache Valley virus assessed using ecological niche modeling. Parasit Vectors 2024 Jun 26;17(1):270.
    doi: 10.1186/s13071-024-06344-zpubmed: 38926834google scholar: lookup
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