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Veterinary and animal science2021; 12; 100176; doi: 10.1016/j.vas.2021.100176

Short-term infusion of ultralow-dose dopamine in an adult horse with acute kidney injury: A case report.

Abstract: Much is known regarding a good prognosis of acute kidney injury (AKI) is achieved with adequate, intensive, and early treatment, which leads to acceleration of the renal blood flow rate and associated urination. Low-dose dopamine (1 to 5 μg/kg bwt per min) is a treatment option for AKI in humans but remains controversial for use in horses because of the lack of extensive clinical trial data. A 19-year-old Westfalen horse gelding was referred to the Animal Medical Center with a 1-hour history of mild abdominal pain and anorexia after dressage exercise for 1 hour. Since elevated serum levels of blood urea nitrogen (BUN) and creatinine were found on days 4 and 5, the horse was diagnosed with AKI. In addition to basic hydration therapy with lactated Ringer's solution, we decided to use ultralow-dose dopamine because of the possibilities of the upregulation of dopamine receptors in the affected kidney and general large animal specificity of drug doses. Infusions with 0.04 and 0.02 μg/kg bwt per min for 1 hour on days 6 and 7, respectively, were effective in decreasing serum levels of BUN and creatinine accompanied with a diuretic effect. Thus, short-term infusion of ultralow-dose dopamine may be useful in controlling the renal blood flow rate and clinical conditions in horses with AKI.
© 2021 The Authors. Published by Elsevier Ltd.
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Publication Date: 2021-04-11 PubMed ID: 33912729PubMed Central: PMC8066775DOI: 10.1016/j.vas.2021.100176Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study examines the use of ultralow-dose dopamine to treat acute kidney injury (AKI) in a horse, showing a drop in blood urea nitrogen and creatinine levels when administered over a short term.

Introduction

  • The focus of the research was to explore and evaluate the effectiveness of using ultralow-dose dopamine as a treatment method for acute kidney injury (AKI) in horses.
  • The prognosis for AKI usually depends on how early and intensively the condition is treated. The quicker the renal blood flow rate is accelerated, the sooner urination resumes, leading to a potentially positive outcome.
  • Low-dose dopamine is an established treatment option for AKI in humans, but its application in horses remains controversial due to the scarcity of extensive clinical trial data supporting its use.

Case Overview

  • The subject of this study was a 19-year-old Westfalen horse gelding. It was referred to the Animal Medical Center following reports of mild abdominal pain and anorexia which emerged an hour after it had undertaken an hour of dressage exercise.
  • Focusing on the horse’s condition, raised serum levels of blood urea nitrogen (BUN) and creatinine were discovered on the fourth and fifth days. This led to a diagnosis of AKI.

Treatment Details and Results

  • The treatment chosen involved the combination of basic hydration therapy with lactated Ringer’s solution and the use of ultralow-dose dopamine. This decision was determined by considerations related to potential upregulations of dopamine receptors in the kidney affected and the general specifics of large animal drug doses.
  • This treatment method was deemed effective, as infusions of 0.04 and 0.02 μg/kg bwt per min were administered for an hour on day 6 and 7 respectively, and resulted in a decrease in serum BUN and creatinine levels. A diuretic effect was also noted.

Conclusion

  • The findings suggest that short-term infusion of ultralow-dose dopamine could be beneficial in managing the renal blood flow rate, as well as the overall clinical conditions in horses diagnosed with AKI.
  • This highlights the potential for further exploration and research into the use of dopamine for treatment of AKI in horses and possibly other large animals.

Cite This Article

APA
Matsuda H, Matsuda K, Muko R, Oikawa MA, Tanaka A. (2021). Short-term infusion of ultralow-dose dopamine in an adult horse with acute kidney injury: A case report. Vet Anim Sci, 12, 100176. https://doi.org/10.1016/j.vas.2021.100176

Publication

Veterinary and animal science
ISSN: 2451-943X
NlmUniqueID: 101694897
Country: Netherlands
Language: English
Volume: 12
Pages: 100176
PII: 100176

Researcher Affiliations

Matsuda, Hiroshi
  • Laboratory of Comparative Animal Medicine, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Matsuda, Kenshiro
  • Laboratory of Comparative Animal Medicine, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Muko, Ryo
  • Cooperative Major in Advanced Health Science, Graduate School of Bio-Applications and System Engineering, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Oikawa, Masa-Aki
  • Diagnostic and Research Laboratory, Equine Veterinary Medical Center, Education City, Doha, Qatar.
Tanaka, Akane
  • Laboratory of Comparative Animal Medicine, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan.
  • Cooperative Major in Advanced Health Science, Graduate School of Bio-Applications and System Engineering, Tokyo University of Agriculture and Technology, Tokyo, Japan.

Conflict of Interest Statement

The authors have declared that no conflict of interest exists.

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Citations

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