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Home / Equine Research Bank / Biol Reprod / Sperm migration, selection, survival, and fertilizing abilit...
Biology of reproduction2021; 105(2); 317-331; doi: 10.1093/biolre/ioab105

Sperm migration, selection, survival, and fertilizing ability in the mammalian oviduct†.

Abstract: In vitro fertilization (IVF) gives rise to embryos in a number of mammalian species and is currently widely used for assisted reproduction in humans and for genetic purposes in cattle. However, the rate of polyspermy is generally higher in vitro than in vivo and IVF remains ineffective in some domestic species like pigs and horses, highlighting the importance of the female reproductive tract for gamete quality and fertilization. In this review, the way the female environment modulates sperm selective migration, survival, and acquisition of fertilizing ability in the oviduct is being considered under six aspects: (1) the utero-tubal junction that selects a sperm sub-population entering the oviduct; (2) the presence of sperm binding sites on luminal epithelial cells in the oviduct, which prolong sperm viability and plays a role in limiting polyspermic fertilization; (3) the contractions of the oviduct, which promote sperm migration toward the site of fertilization in the ampulla; (4) the regions of the oviduct, which play different roles in regulating sperm physiology and interactions with oviduct epithelial cells; (5) the time of ovulation, and (6) the steroid hormonal environment which regulates sperm release from the luminal epithelial cells and facilitates capacitation in a finely orchestrated manner.
© The Author(s) 2021. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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Publication Date: 2021-06-01 PubMed ID: 34057175PubMed Central: PMC8335357DOI: 10.1093/biolre/ioab105Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article reviews how the female reproductive tract influences sperm migration, selection, survival, and fertilizing ability in the oviduct, offering clues for improving in vitro fertilization (IVF) outcomes and better understanding some of the challenges in assisted reproduction in some domestic animals like pigs and horses.

Sperm Migration and Selection: Utero-tubal Junction

  • The paper discusses the role of the utero-tubal junction – the point where the uterus connects to the fallopian tubes. It’s suggested to perform a selection process on sperm, allowing only a chosen sub-population to progress into the oviduct where fertilization can potentially happen.

Sperm Survival: Luminal Epithelial Cells

  • The study explores the presence of sperm-binding sites on luminal epithelial cells in the oviduct. These cells are suggested to promote sperm viability and limit polyspermic fertilization, where an egg is fertilized by more than one sperm, through these binding sites where sperm can attach.

Sperm Migration: Oviduct Contractions

  • The authors discuss how contractions of the oviduct help promote sperm migration toward the ampulla, the location where fertilization usually occurs. These contractions assist sperm in their journey towards the egg.

Regulation of Sperm Physiology: Oviduct Regions

  • Different regions of the oviduct are considered in the paper, each believed to play a unique role in regulating sperm physiology and their interactions with oviduct epithelial cells.

Ovulation Timing

  • The paper also explores the relevance of the timing of ovulation. If fertilization is to occur, sperm must be present in the female reproductive tract around the time when the egg is released from the ovary, thus demonstrating the importance of the synchronisation of ovulation and sperm presence in successful fertilization.

Steroid Hormonal Environment

  • Lastly, the authors discuss how a female’s steroid hormonal environment helps orchestrate sperm release from the luminal epithelial cells and facilitates capacitation, the process by which sperm gain the ability to fertilize the egg. This hormonal environment is thought to finely balance these processes for optimal fertilization probability.

This review suggests a need for additional studies into the complex environment of the female reproductive tract to improve IVF outcomes and better understand infertility in some domestic animals. Understanding these mechanics could lead to advancements in assisted reproduction techniques in the future.

Cite This Article

APA
Mahé C, Zlotkowska AM, Reynaud K, Tsikis G, Mermillod P, Druart X, Schoen J, Saint-Dizier M. (2021). Sperm migration, selection, survival, and fertilizing ability in the mammalian oviduct†. Biol Reprod, 105(2), 317-331. https://doi.org/10.1093/biolre/ioab105

Publication

Biology of reproduction
ISSN: 1529-7268
NlmUniqueID: 0207224
Country: United States
Language: English
Volume: 105
Issue: 2
Pages: 317-331

Researcher Affiliations

Mahé, Coline
  • CNRS, IFCE, INRAE, Université de Tours, PRC, Nouzilly, France.
Zlotkowska, Aleksandra Maria
  • Institute of Reproductive Biology, Leibniz Institute for Farm Animal Biology, FBN, Dummerstorf, Germany.
Reynaud, Karine
  • CNRS, IFCE, INRAE, Université de Tours, PRC, Nouzilly, France.
Tsikis, Guillaume
  • CNRS, IFCE, INRAE, Université de Tours, PRC, Nouzilly, France.
Mermillod, Pascal
  • CNRS, IFCE, INRAE, Université de Tours, PRC, Nouzilly, France.
Druart, Xavier
  • CNRS, IFCE, INRAE, Université de Tours, PRC, Nouzilly, France.
Schoen, Jennifer
  • Institute of Reproductive Biology, Leibniz Institute for Farm Animal Biology, FBN, Dummerstorf, Germany.
Saint-Dizier, Marie
  • CNRS, IFCE, INRAE, Université de Tours, PRC, Nouzilly, France.
  • Tours University, Faculty of Sciences and Techniques, Agrosciences Department, Tours, France.

MeSH Terms

  • Animals
  • Cell Movement
  • Cell Survival
  • Female
  • Fertilization
  • Humans
  • Male
  • Mammals
  • Oviducts / physiology
  • Spermatozoa / physiology

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