Sublingual microcirculation in isoflurane-anesthetized horses receiving dexmedetomidine and lidocaine constant rate infusion.
Abstract: To assess the sublingual microcirculation in horses anesthetized with isoflurane and undergoing constant rate infusion of dexmedetomidine (DEX) and lidocaine (LID). Unassigned: 16 horses undergoing arthroscopy were included in a blind, randomized study comparing 2 groups: a DEX group (DEX-LID; 1.75 μg·kg-1·h-1 with a LID bolus of 1.3 mg·kg-1 followed by a continuous infusion of 0.05 mg·kg-1·min-1) and a LID-only group (LID; at the same dose). Hemodynamic variables, including mean, systolic, and diastolic blood pressure; heart rate; capnography; blood gas analysis; blood lactate; and orthogonal polarization spectral imaging were measured. Measurements were taken before infusion and at 15, 30, and 60 minutes after infusion initiation. Unassigned: No differences were observed in microcirculation variables between the groups. At 60 minutes, the total vessel density was 18.73 ± 0.97, the microvascular flow index 3.59 ± 0.39, and the De Backer score 12.4 ± 0.95 in the DEX-LID group. The total vessel density was 20.15 ± 2.23, microvascular flow index 3.62 ± 0.5, and De Backer score 13.41 ± 2.32 for the LID group. Notably, 5 of 8 horses in the LID group required ephedrine for hypotension management (mean arterial pressure < 65 mm Hg), whereas none in the DEX-LID group did. Unassigned: The combination of DEX and LID during isoflurane anesthesia provided stable hemodynamic conditions during arthroscopic surgery in horses without adversely affecting sublingual microcirculation or recovery. Unassigned: These findings support that the combination of DEX and LID maintains hemodynamic variables during surgery without compromising microcirculation function.
Publication Date: 2025-04-14 PubMed ID: 40228545DOI: 10.2460/ajvr.24.11.0340Google Scholar: Lookup
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Summary
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The research study evaluates the effect of dexmedetomidine and lidocaine constant rate infusion on the sublingual microcirculation in isoflurane-anesthetized horses undergoing arthroscopy. It concludes that the combination of these drugs maintains stable hemodynamic conditions without affecting sublingual microcirculation or recovery.
Research Design and Methodology
- The study was conducted on 16 horses randomized into two groups, which were blinded and unassigned.
- The first group received dexmedetomidine (DEX) and lidocaine (LID) at a constant rate infusion.
- The second group received only lidocaine (LID) at the same dose.
- Various hemodynamic variables were measured, such as mean, systolic, and diastolic blood pressure; heart rate; capnography; blood gas analysis; and blood lactate.
- In addition, orthogonal polarization spectral imaging was used to assess sublingual microcirculation.
- These measurements were taken before and at 15-minute intervals up to 60 minutes after the start of the infusion.
Key Findings
- There was no significant difference observed in microcirculation variables between the two groups.
- Notably, the total vessel density, the microvascular flow index, and the De Backer score, which are measures of capillary density and blood flow, were similar in both groups at the 60-minute mark.
- However, it was observed that five out of eight horses in the LID group required ephedrine for the management of hypotension (low blood pressure), while none in the DEX-LID group did.
Conclusion and Implications
- The combination of DEX and LID during isoflurane anesthesia provided stable hemodynamic conditions during arthroscopic surgery in horses without adversely affecting sublingual microcirculation or the recovery process.
- These findings suggest that the combination of DEX and LID can be used to maintain hemodynamic stability during surgery without compromising microcirculation function.
Cite This Article
APA
Garcia LL, Vicentini YF, Nagashima JK, de Souza AF, Pereira MAA, da Silva LCLC, Fantoni DT.
(2025).
Sublingual microcirculation in isoflurane-anesthetized horses receiving dexmedetomidine and lidocaine constant rate infusion.
Am J Vet Res, 1-8.
https://doi.org/10.2460/ajvr.24.11.0340 Publication
Researcher Affiliations
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