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Home / Equine Research Bank / Adv Healthc Mater / Systematic Comparison of Biomaterials-Based Strategies for O...
Advanced healthcare materials2021; 10(20); e2100878; doi: 10.1002/adhm.202100878

Systematic Comparison of Biomaterials-Based Strategies for Osteochondral and Chondral Repair in Large Animal Models.

Abstract: Joint repair remains a major challenge in orthopaedics. Recent progress in biomaterial design has led to the fabrication of a plethora of promising devices. Pre-clinical testing of any joint repair strategy typically requires the use of large animal models (e.g., sheep, goat, pig or horse). Despite the key role of such models in clinical translation, there is still a lack of consensus regarding optimal experimental design, making it difficult to draw conclusions on their efficacy. In this context, the authors performed a systematic literature review and a risk of bias assessment on large animal models published between 2010 and 2020, to identify key experimental parameters that significantly affect the biomaterial therapeutic outcome and clinical translation potential (including defect localization, animal age/maturity, selection of controls, cell-free versus cell-laden). They determined that mechanically strong biomaterials perform better at the femoral condyles; while highlighted the importance of including native tissue controls to better evaluate the quality of the newly formed tissue. Finally, in cell-laded biomaterials, the pre-culture conditions played a more important role in defect repair than the cell type. In summary, here they present a systematic evaluation on how the experimental design of preclinical models influences biomaterial-based therapeutic outcomes in joint repair.
© 2021 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH.
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Publication Date: 2021-08-18 PubMed ID: 34405587DOI: 10.1002/adhm.202100878Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't
  • Review
  • Systematic Review

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research involves a systematic review of studies on biomaterial-based strategies for joint repair in large animal models. The findings indicate that experimental design plays a significant role in the effectiveness of such strategies, as evidenced by important parameters such as defect positioning and animal age or maturity.

Introduction and Background

  • The paper discusses a growing challenge in orthopaedics, which is joint repair. Due to advancements in biomaterial design, many promising solutions have been developed.
  • Large animal models such as sheep, goats, pigs, or horses are frequently used for pre-clinical testing of joint repairs. However, there’s a lack of consensus on the best experimental design, which complicates the assessment of their efficacy.

Methodology

  • The researchers conducted a systematic review of literature and performed a risk-bias assessment on studies conducted on large animal models between 2010 and 2020.
  • The main objective was to identify pivotal experimental parameters that can significantly affect the therapeutic outcomes of biomaterials in joint repairs, and their potential for clinical translation.

Findings

  • The researchers found, for instance, that mechanically strong biomaterials work better at the femoral condyles, and emphasized the need for including native tissue controls to evaluate the quality of newly formed tissue effectively.
  • They also discovered that with cell-laden biomaterials, the conditions under which cells were pre-cultured played a more significant role in defect repair than the type of cell used.
  • The study is an important contribution to the field as it presents a systematic assessment of how outcomes of pre-clinical models for joint repair can be influenced by the experimental design chosen.

Implications

  • The findings are significant as they shed light on some of the previously unaddressed aspects of how biomaterials can be optimally used for joint repairs.
  • The data gleaned can inform decisions on the most effective experimental design and parameters to maximize the outcome of biomaterial-based therapeutic strategies.
  • This has the potential to accelerate the clinical application of these interventions and ultimately improve the quality of life for patients struggling with joint issues.

Cite This Article

APA
González Vázquez AG, Blokpoel Ferreras LA, Bennett KE, Casey SM, Brama PA, O'Brien FJ. (2021). Systematic Comparison of Biomaterials-Based Strategies for Osteochondral and Chondral Repair in Large Animal Models. Adv Healthc Mater, 10(20), e2100878. https://doi.org/10.1002/adhm.202100878

Publication

Advanced healthcare materials
ISSN: 2192-2659
NlmUniqueID: 101581613
Country: Germany
Language: English
Volume: 10
Issue: 20
Pages: e2100878

Researcher Affiliations

González Vázquez, Arlyng G
  • Tissue Engineering Research Group, Department of Anatomy and Regenerative Medicine, Royal College of Surgeons in Ireland (RCSI), Dublin, 2 D02 YN77, Ireland.
  • Advanced Materials Bio-Engineering Research Centre (AMBER), RCSI and TCD, Dublin, 2 D02 PN40, Ireland.
Blokpoel Ferreras, Lia A
  • Tissue Engineering Research Group, Department of Anatomy and Regenerative Medicine, Royal College of Surgeons in Ireland (RCSI), Dublin, 2 D02 YN77, Ireland.
  • Advanced Materials Bio-Engineering Research Centre (AMBER), RCSI and TCD, Dublin, 2 D02 PN40, Ireland.
Bennett, Kathleen E
  • Division of Population Health Science, RCSI, Dublin, 2 D02 YN77, Ireland.
Casey, Sarah M
  • Tissue Engineering Research Group, Department of Anatomy and Regenerative Medicine, Royal College of Surgeons in Ireland (RCSI), Dublin, 2 D02 YN77, Ireland.
  • Advanced Materials Bio-Engineering Research Centre (AMBER), RCSI and TCD, Dublin, 2 D02 PN40, Ireland.
Brama, Pieter Aj
  • School of Veterinary Medicine, University College Dublin (UCD), Dublin, 4 D04 V1W8, Ireland.
O'Brien, Fergal J
  • Tissue Engineering Research Group, Department of Anatomy and Regenerative Medicine, Royal College of Surgeons in Ireland (RCSI), Dublin, 2 D02 YN77, Ireland.
  • Advanced Materials Bio-Engineering Research Centre (AMBER), RCSI and TCD, Dublin, 2 D02 PN40, Ireland.
  • Trinity Centre for Biomedical Engineering, Trinity Biomedical Sciences Institute, Trinity College Dublin (TCD), Dublin, 2 D02 PN40, Ireland.

MeSH Terms

  • Animals
  • Biocompatible Materials
  • Cartilage, Articular
  • Horses
  • Knee Joint
  • Models, Animal
  • Sheep
  • Swine
  • Tissue Engineering

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Citations

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