The coagulation system in horses with colic.

This research paper investigates how colic in horses often leads to changes in the coagulation system and promotes the development of disseminated intravascular clotting. Key indices of the coagulation system are studied to assist diagnosis and treatment of colic in horses.

Overview of Coagulation System Alterations in Horses with Colic

• The study reveals that colic, a common disorder among horses, often induces changes in the coagulation system, eventually leading to widespread intravascular clotting. This clotting is known as Disseminated Intravascular Coagulation (DIC).
• This coagulation or clotting is promoted by a myriad of factors. One significant factor is the increase in blood concentration, which expedites the exposure of coagulation activators.
• Simultaneously, there is a decrease in the activity of coagulation inhibitors, particularly antithrombin III, further fostering the coagulation process.

Blood Platelets Aggregation and Complications

• The paper highlights that as colic progresses, there is an increasing aggregation of blood platelets. This proliferation supports the production of microthromboses and the blockage of capillary vessels.
• The progression of these processes not only complicates the primary disease but also makes therapeutic interventions less effective.

Determination of Coagulation System Indices

• The research underlines the importance of determining various indexes of the coagulation system for effective diagnosis and treatment of colic in horses. For instance, regular monitoring of platelet count can provide essential insights into the horse’s coagulation status.
• Other significant indices include prothrombin time, activated partial thromboplastin time, thrombin time, fibrinogen and fibrinogen degradation products concentration.
• Index measures related to D-dimer (a fibrin degradation product) and antithrombin III contents can further facilitate adequate diagnosis.

Applications of the Research

• This research into alterations in the coagulation system caused by equine colic can facilitate development of more targeted and effective therapeutic strategies for horses suffering from this condition.
• By understanding the complex dynamics of the coagulation system during a colic episode, clinicians can better anticipate and manage potential complications, thereby enhancing the welfare of the affected horses.