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The comparative biology of pulmonary intravascular macrophages.
Abstract: Pulmonary intravascular macrophages are an important part of the mononuclear phagocyte system in some species of mammals, mainly sheep and other ruminants, pigs, and horses. These cells phagocytize foreign particles, cell debris and pathogens that pass through the pulmonary circulation. Species with intravascular macrophages localize intravenously injected tracer particles and bacteria predominantly in the lung rather than the liver, and exhibit pulmonary hypertension when these cells are activated. Both in vivo and in vitro studies show that pulmonary intravascular macrophages have distinct secretory and immune capabilities. Consequently, the pulmonary intravascular macrophages play an important role in pulmonary inflammation in species that have them
Publication Date: 1997-06-01 PubMed ID: 9195895DOI: 10.2741/a186Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
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Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research paper discusses the unique role and biology of pulmonary intravascular macrophages (cells that consume harmful particles and pathogens) in certain mammals, primarily sheep, pigs, and horses.
Understanding Pulmonary Intravascular Macrophages
- The study begins by explaining the presence and significance of pulmonary intravascular macrophages in specific mammals. These cells play a crucial role in the mononuclear phagocyte system, defending the body against foreign particles and pathogens that might harm the pulmonary circulation.
- The cells are specifically located in the lungs, not the liver, mainly in animals like sheep, pigs, and horses. These animals exhibit symptoms of pulmonary hypertension when these macrophages are activated, an occurrence different from many other species.
Intravascular Macrophages’ Secretory and Immune Capabilities
- The study then delves into how pulmonary intravascular macrophages possess distinct secretory and immune capabilities. Both in vitro (in the lab) and in vivo (in the body) studies confirmed this, showing these cells’ unique behavior compared to other macrophages.
The Role in Pulmonary Inflammation
- The research concludes by highlighting the role of these cells in pulmonary inflammation. As these unique macrophages are predominantly found in the lungs recovering foreign particles and pathogens, they contribute significantly to any inflammation in the pulmonary system in species that host them.
The study broadens the understanding of how different species’ immune systems operate and how certain diseases and conditions may uniquely affect them due to the presence of these specific cells.
Cite This Article
APA
Longworth KE.
(1997).
The comparative biology of pulmonary intravascular macrophages.
Front Biosci, 2, d232-d241.
https://doi.org/10.2741/a186 Publication
Researcher Affiliations
- Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA. kelongworth@ucdavis.edu
MeSH Terms
- Animals
- Hemodynamics
- Humans
- Immune System / physiology
- Lung / blood supply
- Lung / immunology
- Lung / physiology
- Lung Diseases / physiopathology
- Macrophages, Alveolar / physiology
- Macrophages, Alveolar / ultrastructure
Citations
This article has been cited 9 times.- Bain CC, Lucas CD, Rossi AG. Pulmonary macrophages and SARS-Cov2 infection. Int Rev Cell Mol Biol 2022;367:1-28.
- Kosyreva A, Dzhalilova D, Lokhonina A, Vishnyakova P, Fatkhudinov T. The Role of Macrophages in the Pathogenesis of SARS-CoV-2-Associated Acute Respiratory Distress Syndrome. Front Immunol 2021;12:682871.
- Robinson K, Platt S, Bibi K, Banovic F, Barber R, Howerth EW, Madsen G. A Pilot Study on the Safety of a Novel Antioxidant Nanoparticle Delivery System and Its Indirect Effects on Cytokine Levels in Four Dogs. Front Vet Sci 2020;7:447.
- Bordet E, Maisonnasse P, Renson P, Bouguyon E, Crisci E, Tiret M, Descamps D, Bernelin-Cottet C, Urien C, Lefèvre F, Jouneau L, Bourry O, Leplat JJ, Schwartz-Cornil I, Bertho N. Porcine Alveolar Macrophage-like cells are pro-inflammatory Pulmonary Intravascular Macrophages that produce large titers of Porcine Reproductive and Respiratory Syndrome Virus. Sci Rep 2018 Jul 5;8(1):10172.
- Gómez-Laguna J, Salguero FJ, Pallarés FJ, Carrasco L. Immunopathogenesis of porcine reproductive and respiratory syndrome in the respiratory tract of pigs. Vet J 2013 Feb;195(2):148-55.
- Thenappan T, Goel A, Marsboom G, Fang YH, Toth PT, Zhang HJ, Kajimoto H, Hong Z, Paul J, Wietholt C, Pogoriler J, Piao L, Rehman J, Archer SL. A central role for CD68(+) macrophages in hepatopulmonary syndrome. Reversal by macrophage depletion. Am J Respir Crit Care Med 2011 Apr 15;183(8):1080-91.
- Harris A, Burnham K, Pradhyumnan R, Jaishankar A, Häkkinen L, Góngora-Rosero RE, Piazza Y, Andl CD, Andl T. Human-Specific Organization of Proliferation and Stemness in Squamous Epithelia: A Comparative Study to Elucidate Differences in Stem Cell Organization. Int J Mol Sci 2025 Mar 28;26(7).
- Perdrizet UG, Hill JE, Sobchishin L, Singh B, Fernando C, Bollinger TK, Misra V. Tissue and cellular tropism of Eptesicus fuscus gammaherpesvirus in big brown bats, potential role of pulmonary intravascular macrophages. Vet Pathol 2024 Jul;61(4):550-561.
- Ruedas-Torres I, Sánchez-Carvajal JM, Salguero FJ, Pallarés FJ, Carrasco L, Mateu E, Gómez-Laguna J, Rodríguez-Gómez IM. The scene of lung pathology during PRRSV-1 infection. Front Vet Sci 2024;11:1330990.
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