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The development of the lung and its surfactant in the foal and in other species.
Abstract: The development of the lung from the glandular through the canalicular to the alveolar stages in the horse fetus is described. Traces of surfactant and occasional lamellated osmiophilic bodies representing intracellular surfactant were found at 150 days of gestation, some 40 to 60 days before the transition to the canalicular stage. During this transition some of the cuboidal cells of the glandular rosettes are transformed into cells of Types I and II, but the surfactant is not fully developed until 300 days or, in some foals, until after delivery.
Publication Date: 1975-10-01 PubMed ID: 1060861 The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
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This research study unravels the sequential lung development process in horse fetuses, tracing the appearance of surfactant and lamellated osmiophilic bodies from the glandular stage to the alveolar stage, and noting the transformation of cellar types. The full development of the surfactant is pinpointed at around 300 days or sometimes post delivery.
Lung Development Stages in Horse Fetuses
- The research outlines the phases of lung development in horse fetuses from the glandular to the alveolar stages. Each stage is characterized by distinct structural features and cell changes that contribute to the lung’s functionality.
- The glandular stage is preliminary, with the lung only starting to form structures named glandular rosettes.
- From around 150 days of gestation, transition begins towards the canalicular stage. This is signified by the appearance of surfactant and occasional lamellated osmiophilic bodies, which are structures related to the formation of surfactant in the cell.
Cell Transformation During Development
- During the transition from the glandular to the canalicular stage, certain cuboidal cells of the glandular rosettes are transformed into Types I and II cells.
- Type I cells are involved in the process of gas exchange, and Type II cells are responsible for producing and secreting surfactant, a substance crucial in preventing the lungs from collapsing.
Surfactant Development
- In the study, it is observed that surfactant is not fully developed until approximately 300 days of gestation. In some cases, the full development takes place only after the horse has been delivered.
- The surfactant is key to lung function as it helps to lower the tension of pulmonary fluids, thereby permitting expansion of the lungs and facilitating respiration.
This research presents important findings on lung development stages and cellular changes in horse fetuses, thereby contributing to our understanding of mammalian lung growth and development.
Cite This Article
APA
Pattle RE, Rossdale PD, Schock C, Creasey JM.
(1975).
The development of the lung and its surfactant in the foal and in other species.
J Reprod Fertil Suppl(23), 651-657.
Publication
Researcher Affiliations
MeSH Terms
- Animals
- Fetus
- Gestational Age
- Horses / embryology
- Lung / embryology
- Lung / ultrastructure
- Pulmonary Surfactants / biosynthesis
Citations
This article has been cited 2 times.- Slauson DO, Hahn FF. Criteria for development of animal models of diseases of the respiratory system: the comparative approach in respiratory disease model development. Am J Pathol 1980 Dec;101(3 Suppl):S103-22.
- Platt H. Growth and maturity in the equine fetus. J R Soc Med 1978 Sep;71(9):658-61.
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