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Equine veterinary journal. Supplement2011; (39); 140-144; doi: 10.1111/j.2042-3306.2011.00398.x

The effect of nonsteroidal anti-inflammatory drugs on the equine intestine.

Abstract: Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used in the management of pain and endotoxaemia associated with colic in the horse. While NSAIDs effectively treat the symptoms of colic, there is evidence to suggest that their administration is associated with adverse gastrointestinal effects including right dorsal colitis and inhibition of mucosal barrier healing. Several studies have examined the pathophysiology of NSAID associated effects on the large and small intestine in an effort to avoid these complications and identify effective alternative medications. Differences in the response of the large and small intestines to injury and NSAID treatment have been identified. Flunixin meglumine has been shown in the small intestine to inhibit barrier function recovery and increase permeability to lipopolysaccharide (LPS). A range of NSAIDs has been examined in the small intestine and experimental evidence suggests that those NSAIDs with cyclooxygenase independent anti-inflammatory effects or a COX-2 selective mode of action may offer significant advantages over traditional NSAIDs.
© 2011 EVJ Ltd.
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Publication Date: 2011-08-04 PubMed ID: 21790769DOI: 10.1111/j.2042-3306.2011.00398.xGoogle Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research highlights the effects of Nonsteroidal anti-inflammatory drugs (NSAIDs) on the equine intestine, especially in the treatment of horse colic. It points out the potential adverse effects and further shows a difference in the impact of various NSAIDs on the large and small intestines.

Understanding the use of NSAIDs in Colic Treatment

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used in managing symptoms of colic in horses such as pain and endotoxaemia.
  • The research underscores that administration of these drugs has potentially adverse gastrointestinal effects. Examples of these adverse effects include right dorsal colitis and inhibition of mucosal barrier healing.

Examination of NSAID Effects on Intestine

  • Several studies have been carried out focusing on the pathophysiology of NSAIDs and how they affect the large and small intestines, with an aim of avoiding complications and identifying alternative effective medications.
  • Differences have been identified in the way the large and small intestines respond to injury and NSAID treatment.

Effects of Specific NSAIDs on the Intestine

  • Flunixin meglumine, an NSAID, has been shown particularly in the small intestine, to inhibit barrier function recovery and increase permeability to lipopolysaccharide (LPS), a major component of the outer membrane of Gram-negative bacteria.
  • Various NSAIDs have been evaluated in the small intestine and it was observed that NSAIDs with cyclooxygenase independent anti-inflammatory effects or a COX-2 selective mode of action might present significant advantages over traditional NSAIDs.

    • The above points out the need for considering the different effects of various NSAIDs on either the large or small intestine when formulating treatment plans for horses, particularly those with colic.

Cite This Article

APA
Marshall JF, Blikslager AT. (2011). The effect of nonsteroidal anti-inflammatory drugs on the equine intestine. Equine Vet J Suppl(39), 140-144. https://doi.org/10.1111/j.2042-3306.2011.00398.x

Publication

Equine veterinary journal. Supplement
NlmUniqueID: 9614088
Country: United States
Language: English
Issue: 39
Pages: 140-144

Researcher Affiliations

Marshall, J F
  • Weipers Centre Equine Hospital, School of Veterinary Medicine, University of Glasgow, UK. John.F.Marshall@glasgow.ac.uk
Blikslager, A T

    MeSH Terms

    • Animals
    • Anti-Inflammatory Agents, Non-Steroidal / adverse effects
    • Gastrointestinal Diseases / chemically induced
    • Gastrointestinal Diseases / veterinary
    • Horse Diseases / chemically induced
    • Horses
    • Intestines / drug effects

    Citations

    This article has been cited 18 times.
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