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PloS one2024; 19(3); e0299990; doi: 10.1371/journal.pone.0299990

The effects of a synthetic epidermis spray on secondary intention wound healing in adult horses.

Abstract: To evaluate secondary intention wound healing in the horse's limbs when treated with the synthetic epidermis spray (Novacika®, Cohesive S.A.S, France) or with a standard bandaging technique. Methods: Six Standardbred mares were included in the study. Four 2.5 x 2.5 cm full-thickness skin wounds were created on each thoracic limb. Two wounds were located on the dorsoproximal aspect of the cannon bone and the other two at the dorsoproximal aspect of the fetlock. Six hours after creation, wounds were randomly treated with synthetic epidermis spray or standard bandaging. The wounds were assessed every 4 days by gross visual assessment and using a 3D imaging camera. Analysis was performed with a 3D imaging application. Results: Out of 46 wounds, 22 showed exuberant granulation tissue and were part of the standard bandaging group. Whether the wounds were treated with synthetic epidermis spray or standard bandaging, the time for healing was the same. Conclusions: The synthetic epidermis spray studied in this model has allowed healing without the production of exuberant granulation tissue but did not reduce the median wound healing time compared to a standard bandaging technique. The synthetic epidermis spray is potentially an interesting alternative for the management of secondary intention wound healing of superficial and non-infected distal limb wounds in adult horses on economical and practical aspects. However, all statistical inference (p-values especially) must be interpreted with caution, given the size of the sample.
Copyright: © 2024 Charlotte C. et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Publication Date: 2024-03-07 PubMed ID: 38451976PubMed Central: PMC10919598DOI: 10.1371/journal.pone.0299990Google Scholar: Lookup
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  • Journal Article
  • Randomized Controlled Trial
  • Veterinary

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research paper studies the effect of a synthetic skin spray on the wound healing process in adult horses, comparing it to standard bandaging technique. The study found that the spray allowed for healing without excessive tissue growth yet didn’t speed up the healing process compared to bandaging.

Methods:

  • The study was conducted on six Standardbred mares.
  • Four full-thickness skin wounds each measuring 2.5 x 2.5 cm were created on each thoracic limb of the horses.
  • Two of these wounds were placed on the upper front part of the cannon bone, and the other two were placed at the upper front part of the fetlock.
  • After six hours, the wounds were treated randomly either with a synthetic skin spray (Novacika®, Cohesive S.A.S, France) or a standard bandage.
  • The condition of the wounds was visually assessed and monitored using a 3D imaging camera every four days.
  • The 3D images of the wounds were analyzed using a specific application.

Results:

  • 22 out of 46 wounds showed overgrowth of granulation tissue. These wounds were part of the group treated with standard bandaging.
  • The time taken for wound healing was observed to be the same regardless of whether the wound was treated with the spray or standard bandaging.

Conclusions:

  • The synthetic skin spray allowed the wounds to heal without the formation of excessive granulation tissue. However, it did not reduce the time taken for wound healing compared to standard bandaging.
  • The synthetic skin spray can be considered a practical and economical alternative for managing wound healing in adult horses. This is particularly relevant for superficial, non-infected wounds on the lower limb.
  • However, the researchers advise caution when interpreting the statistical results (p-values, in particular) because of the small sample size used in the study.

Cite This Article

APA
Charlotte C P, Benoit B, Olivier M L. (2024). The effects of a synthetic epidermis spray on secondary intention wound healing in adult horses. PLoS One, 19(3), e0299990. https://doi.org/10.1371/journal.pone.0299990

Publication

PloS one
ISSN: 1932-6203
NlmUniqueID: 101285081
Country: United States
Language: English
Volume: 19
Issue: 3
Pages: e0299990

Researcher Affiliations

Charlotte C, Paindaveine
  • Unité ICE-Groupe de Recherche en Médecine et Rééducation des Equidés de Sport (GREMERES), Centre for Equine Health, Ecole Nationale Vétérinaire de Lyon, VetAgro Sup, Université de Lyon, Lyon, France.
Benoit, Bihin
  • Namur Research Institute for Life Sciences (NARILIS), University of Namur, Namur, Belgium.
Olivier M, Lepage
  • Unité ICE-Groupe de Recherche en Médecine et Rééducation des Equidés de Sport (GREMERES), Centre for Equine Health, Ecole Nationale Vétérinaire de Lyon, VetAgro Sup, Université de Lyon, Lyon, France.

MeSH Terms

  • Animals
  • Female
  • Epidermis
  • Forelimb
  • Horses
  • Intention
  • Skin Diseases
  • Wound Healing

Conflict of Interest Statement

The authors have declared that no competing interests exist.

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