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The immunology of companion animals: reagents and therapeutic strategies with potential veterinary and human clinical applications.
Abstract: There is now a wide range of immunological reagents that can be used in the diagnosis and treatment of diseases in the companion animals (dogs, cats and horses). Many of these diseases are the veterinary equivalents of human conditions, and may therefore provide good models to study basic pathogenic mechanisms.
Publication Date: 1994-08-01 PubMed ID: 7916946DOI: 10.1016/0167-5699(94)90171-6Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
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Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This research paper delves into the realm of immunology concerning companion animals such as dogs, cats, and horses. It studies the application of various immunological reagents in diagnosing and treating diseases in these animals, which in turn can provide insight into similar conditions in humans.
Immunological Reagents in Companion Animals
This section of the paper focuses on the usage and potential of immunological reagents in identifying and treating diseases in companion animals. The wide range of immunological reagents mentioned in the paper includes, but isn’t limited to:
- Antibodies: Used in diagnostic tests and therapies, given their ability to bind to specific antigens present in many disease conditions.
- Vaccines: Employed to boost the immune response against particular pathogens, helping prevent, control, or eliminate diseases.
- Immunosuppressants: Used to control immune-mediated diseases by suppressing or reducing the body’s immune response.
Equivalents of Human Diseases in Animals
Another key focus in the study revolves around diseases in animals that are equivalent to human conditions. This implies that the diseases share similar symptoms, pathogenic mechanisms or causes with certain human illnesses. These connections provide a fertile ground of study for:
- Enhancing our understanding of the disease pathology by comparing its manifestation in different mammalian systems.
- Developing and testing new strategies for diagnosing and treating the respective human conditions, thus using animals as models for human diseases.
- Refining the existing therapeutic strategies, thanks to the newfound insights about the disease mechanisms.
Potential Applications in Veterinary and Human Clinical Practices
The final section of the study explores the potential applications of the findings in veterinary and human clinical practices. This encompasses:
- Veterinary Applications: Enhanced diagnostic and treatment methods for the targeted diseases in companion animals, improving animal health and longevity.
- Human Clinical Applications: Observations on the equivalent diseases in animals can aid in understanding similar human diseases, fostering the development of better diagnostic methods and more effective treatments.
Cite This Article
APA
Cobbold S, Holmes M, Willett B.
(1994).
The immunology of companion animals: reagents and therapeutic strategies with potential veterinary and human clinical applications.
Immunol Today, 15(8), 347-353.
https://doi.org/10.1016/0167-5699(94)90171-6 Publication
Researcher Affiliations
- Sir William Dunn School of Pathology, University of Oxford, UK.
MeSH Terms
- Animals
- Antibodies, Monoclonal / therapeutic use
- Cats / immunology
- Dogs / immunology
- Horses / immunology
- Human-Animal Bond
- Humans
- Immune System Diseases / immunology
- Immune System Diseases / therapy
- Immune System Diseases / veterinary
- Models, Biological
Citations
This article has been cited 2 times.- Yule TD, Roth MB, Dreier K, Johnson AF, Palmer-Densmore M, Simmons K, Fanton R. Canine parvovirus vaccine elicits protection from the inflammatory and clinical consequences of the disease. Vaccine 1997 Apr-May;15(6-7):720-9.
- Rieu P, Ueda T, Haruta I, Sharma CP, Arnaout MA. The A-domain of beta 2 integrin CR3 (CD11b/CD18) is a receptor for the hookworm-derived neutrophil adhesion inhibitor NIF. J Cell Biol 1994 Dec;127(6 Pt 2):2081-91.
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