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Home / Equine Research Bank / Front Vet Sci / The impact of the administration of red ginseng (Panax ginse...
Frontiers in veterinary science2024; 11; 1285000; doi: 10.3389/fvets.2024.1285000

The impact of the administration of red ginseng (Panax ginseng) on lipid metabolism and free fatty acid profiles in healthy horses using a molecular networking approach.

Abstract: This study investigated the potential benefits of the administration of red ginseng (RG) on lipid metabolism and the profiles of individual free fatty acids (FFAs) in healthy horses. Eight healthy horses, raised under similar conditions, were randomly divided into two groups, each comprising four horses. The experimental group received powdered RG (600 mg/kg/day) mixed with a carrier, and the control group received only the carrier. The parameters associated with lipid metabolism and probable adverse effects were evaluated in both groups after 3 weeks. The computational molecular networking (MN) approach was applied to analyze the FFA profiles. The results indicated that RG administration significantly reduced blood triglyceride levels in the experimental group. Analysis of the FFAs using MN revealed significant decreases in specific types of FFAs (C12:0, dodecanoic acid; C14:0, myristric acid; C18:1, oleic acid; C18:2, linoleic acid). RG consumption did not produce significant adverse effects on the renal, hepatic, and immune functions. Thus, RG was found to effectively modulate lipid metabolism and the levels of individual FFAs. The application of the MN for the analysis of FFAs represents a novel approach and can be considered for future research.
Copyright © 2024 Kwak, Yoo and Yoon.
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Publication Date: 2024-01-24 PubMed ID: 38332753PubMed Central: PMC10851614DOI: 10.3389/fvets.2024.1285000Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article examines the effects of red ginseng (a type of herb) on lipid metabolism and free fatty acid profiles in healthy horses. The study found that administering red ginseng can positively alter lipid metabolism and decrease specific types of free fatty acids, with no adverse kidney, liver, or immune system effects.

Introduction and Methodology

  • The research was undertaken to study the effect of red ginseng (RG) on horses’ lipid metabolism and levels of individual free fatty acids (FFAs). Lipids play a crucial role in various physiological processes, and their disbalance can lead to various health complications.
  • The study commenced with eight horses divided equally into two groups – the experimental group and the control group. The horses were raised under uniform conditions to ensure accurate results.
  • The experimental group was given a diet containing powdered RG mixed with a carrier at a dose rate of 600 mg/kg/day. The control group, on the other hand, was only given the carrier.

Measurements and Analysis

  • After three weeks, the horses’ lipid metabolism parameters were tested. Simultaneously, checks were made for potential adverse effects.
  • Furthermore, free fatty acid profiles were analyzed using computational molecular networking. This advanced technology provided a deeper level of understanding of the changes in FFAs.

Results and Conclusion

  • The results showed that the RG administration significantly reduced blood triglyceride levels, pointing to a positive impact on lipid metabolism.
  • The molecular network analysis revealed a notable decrease in certain FFAs, namely dodecanoic acid, myristic acid, oleic acid, and linoleic acid.
  • The study also indicated that consuming RG did not lead to adverse effects on the horses’ renal, hepatic, and immune functions, colloquially known as kidney, liver, and immune system functions.
  • The authors concluded that RG can effectively regulate lipid metabolism and individual FFA levels, confirming its benefits in maintaining health.
  • The use of molecular networking in the analysis of FFA profiles was also justified and encouraged for future research.

Cite This Article

APA
Kwak YB, Yoo HH, Yoon J. (2024). The impact of the administration of red ginseng (Panax ginseng) on lipid metabolism and free fatty acid profiles in healthy horses using a molecular networking approach. Front Vet Sci, 11, 1285000. https://doi.org/10.3389/fvets.2024.1285000

Publication

Frontiers in veterinary science
ISSN: 2297-1769
NlmUniqueID: 101666658
Country: Switzerland
Language: English
Volume: 11
Pages: 1285000
PII: 1285000

Researcher Affiliations

Kwak, Young Beom
  • Racing Laboratory, Korea Racing Authority, Jeju, Republic of Korea.
Yoo, Hye Hyun
  • Institute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University, Ansan, Republic of Korea.
Yoon, Jungho
  • Equine Referral Clinic, Jeju Stud Farm, Korea Racing Authority, Jeju, Republic of Korea.

Conflict of Interest Statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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