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Clinical and experimental immunology1971; 8(4); 529-542;

The intravenous administration of equine antilymphocytic globulin in renal transplant recipients and the detection of circulating antibodies to equine globulin.

Abstract: Methods are described for the intravenous administration of equine antilymphocytic globulin (ALG) to renal transplant recipients. The development of circulating antibodies to the equine IgG has been investigated using primary and secondary immunological procedures. The need for primary immunoassay procedures to assess both the immune response and induction of tolerance to equine IgG in ALG treated patients is extensively discussed.
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Publication Date: 1971-04-01 PubMed ID: 4995934PubMed Central: PMC1712968
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research investigates the method for using equine antilymphocytic globulin (ALG) intravenously in kidney transplant recipients and the process of tracking the development of antibodies against equine IgG. Additionally, it emphasizes the requirement for primary immunoassay procedures for the assessment of both the immune response and the introduction of tolerance to equine IgG in patients treated with ALG.

Administration of Equine Antilymphocytic Globulin

  • The study explores ways to give equine ALG intravenously to recipients of kidney transplants. Equine ALG is an immunosuppressive drug used to prevent organ rejection in transplant patients.
  • The method mentioned here involves direct injections into the bloodstream, making it an invasive approach that will need to be carried out with the utmost precision and care.
  • This part of the study aims to optimize this process, which could minimize potential risks and adverse reactions associated with the administration of the drug.

Detection of Circulating Antibodies Against Equine IgG

  • The research also includes the investigation of the formation of antibodies against equine IgG in the blood of these transplant recipients.
  • These antibodies are produced by the patient’s immune system in response to the equine-derived ALG injected into the patient’s body.
  • The formation of these antibodies could potentially lead to an adverse reaction or possibly reduce the effectiveness of ALG.
  • The study employs both primary and secondary immunological procedures to track this antibody development, suggesting a rigorous and reliable approach.

Primary Immunoassay Procedures

  • The study highlights the need for initial immunoassay tests to measure both the immune response and tolerance induction to equine IgG in ALG-treated patients.
  • These immunoassays are laboratory-based tests that can detect and measure specific proteins associated with different immune responses.
  • The outcome of these tests would furnish valuable insights into how well the patient’s body is accepting the equine ALG and whether the patient’s body is producing an immune response or developing tolerance to the foreign protein.
  • This data can assist in making crucial medical decisions such as whether to continue with the current treatment regimen, the need for additional interventions, or whether to alter the course of treatment completely.

Cite This Article

APA
James K, Pullar DM, Morton JB, Dalton RG, Nolan B, Woodruff MF. (1971). The intravenous administration of equine antilymphocytic globulin in renal transplant recipients and the detection of circulating antibodies to equine globulin. Clin Exp Immunol, 8(4), 529-542.

Publication

Clinical and experimental immunology
ISSN: 0009-9104
NlmUniqueID: 0057202
Country: England
Language: English
Volume: 8
Issue: 4
Pages: 529-542

Researcher Affiliations

James, K
    Pullar, D M
      Morton, J B
        Dalton, R G
          Nolan, B
            Woodruff, M F

              MeSH Terms

              • Anaphylaxis / etiology
              • Animals
              • Antibodies, Anti-Idiotypic / analysis
              • Antibody Formation
              • Antilymphocyte Serum / administration & dosage
              • Antilymphocyte Serum / adverse effects
              • Antilymphocyte Serum / isolation & purification
              • Chromatography, Gel
              • Fever / etiology
              • Hemagglutination Tests
              • Horses
              • Humans
              • Immune Tolerance
              • Immunodiffusion
              • Immunoglobulin G
              • Injections, Intravenous
              • Iodine Isotopes
              • Kidney Transplantation
              • Rabbits
              • Radioimmunoassay
              • Renal Dialysis
              • Transplantation, Homologous

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              Citations

              This article has been cited 3 times.
              1. Waller M, Pierce JC, Moncure CW, Hume DM. Humoral responses in human organ transplantation. Clin Exp Immunol 1972 Jun;11(2):173-86.
                pubmed: 4625156
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              3. Jones VE, Lance EM, Abbosh J, Graves HE. Intensive immunosuppression in patients with disseminated sclerosis. II. Tolerance to equine IgG and effect on immunoglobulin and complement levels. Clin Exp Immunol 1975 Jul;21(1):13-22.
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