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Comparative biochemistry and physiology. A, Comparative physiology1988; 89(3); 401-404; doi: 10.1016/0300-9629(88)91047-x

Total and free thyroxine and triiodothyronine in blood serum of mammals.

Abstract: 1. Blood samples were obtained from seven species of mammals: horses, cattle, sheep, goats, pigs, guinea pigs and rats for determination of total and free thyroxine and triiodothyronine. Total thyroxine in the order listed above in ng/ml was: 15, 60, 79, 185, 53, 45 and 79. Free thyroxine in pg/ml was: 5.9, 10.0, 19.2, 32.1, 21.7, 6.7 and 51.3. 2. Total triiodothyronine in pg/ml was: 677, 1290, 979, 3170, 760, 317 and 1747. Free triiodothyronine in pg/ml was: 3.22, 4.40, 2.60, 6.74, 2.74, 2.42 and 10.88. 3. Percent free thyroxine was high in rats and low in guinea pigs, while percent free triiodothyronine was high in guinea pigs and low in goats. 4. Free thyroxine and percent free thyroxine were higher in some groups of horses, particularly stallions, than in other groups.
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Publication Date: 1988-01-01 PubMed ID: 2896571DOI: 10.1016/0300-9629(88)91047-xGoogle Scholar: Lookup
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  • Comparative Study
  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study analyses the concentrations of different thyroid hormones across seven mammalian species including horses, cattle, sheep, goats, pigs, guinea pigs, and rats.

Research Methodology

  • Blood samples were collected from seven different species of mammals.
  • The key thyroid hormones tested were two types of thyroxine (T4) and triiodothyronine (T3).
  • The researchers particularly distinguished between the total quantity and the quantity of the free form of thyroxine and triiodothyronine hormones in the blood.

Findings

  • The concentration of total thyroxine in the blood varied across species in ng/ml as follows: horses – 15, cattle – 60, sheep – 79, goats – 185, pigs – 53, guinea pigs – 45, and rats – 79.
  • Free thyroxine (unbound to proteins and available to the body) also varied across species in pg/ml as follows: horses – 5.9, cattle – 10.0, sheep – 19.2, goats – 32.1, pigs – 21.7, guinea pigs – 6.7, and rats – 51.3.
  • The study gives the distribution of total triiodothyronine in pg/ml: horses – 677, cattle – 1290, sheep – 979, goats – 3170, pigs – 760, guinea pigs – 317, and rats – 1747.
  • Free triiodothyronine (unbound to proteins and available to the body) was measured in pg/ml as follows: horses – 3.22, cattle – 4.40, sheep – 2.60, goats – 6.74, pigs – 2.74, guinea pigs – 2.42, and rats – 10.88.

Key Observations and Comparisons

  • The study brought forth that rats had a high percentage of free thyroxine while guinea pigs had a low percentage of the same.
  • In contrast, the percentage of free triiodothyronine was high in guinea pigs and low in goats.
  • The distribution of free thyroxine and the percentage of free thyroxine were comparatively higher in some groups of horses, stallions, in particular, than others.

The study thus concluded that the levels and proportions of thyroid hormones such as thyroxine and triiodothyronine vary greatly across different species. It provides an understanding of how these hormones might be functioning differently across different species, thereby aiding in the understanding of the comparative physiology of mammals.

Cite This Article

APA
Anderson RR, Nixon DA, Akasha MA. (1988). Total and free thyroxine and triiodothyronine in blood serum of mammals. Comp Biochem Physiol A Comp Physiol, 89(3), 401-404. https://doi.org/10.1016/0300-9629(88)91047-x

Publication

Comparative biochemistry and physiology. A, Comparative physiology
ISSN: 0300-9629
NlmUniqueID: 1276312
Country: England
Language: English
Volume: 89
Issue: 3
Pages: 401-404

Researcher Affiliations

Anderson, R R
  • Department of Dairy Science, University of Missouri, Columbia 65211.
Nixon, D A
    Akasha, M A

      MeSH Terms

      • Animals
      • Castration
      • Cattle / blood
      • Female
      • Goats / blood
      • Guinea Pigs / blood
      • Horses / blood
      • Male
      • Mammals / blood
      • Pregnancy
      • Rats / blood
      • Sheep / blood
      • Species Specificity
      • Swine / blood
      • Thyroxine / blood
      • Triiodothyronine / blood

      Citations

      This article has been cited 6 times.
      1. Fazio E, Bionda A, Chiofalo V, La Fauci D, Randazzo C, Pino A, Crepaldi P, Attard G, Liotta L, Lopreiato V. Effects of Dietary Enrichment with Olive Cake on the Thyroid and Adrenocortical Responses in Growing Beef Calves. Animals (Basel) 2023 Jun 26;13(13).
        doi: 10.3390/ani13132120pubmed: 37443918google scholar: lookup
      2. Gerhardt P, Begall S, Frädrich C, Renko K, Hildebrandt TB, Holtze S, Heinrich A, Sahm A, Meci X, Köhrle J, Rijntjes E, Henning Y. Comparative analysis of thyroid hormone systems in rodents with subterranean lifestyle. Sci Rep 2023 Feb 22;13(1):3122.
        doi: 10.1038/s41598-023-30179-wpubmed: 36813840google scholar: lookup
      3. Fazio E, Bionda A, Chiofalo V, Crepaldi P, Lopreiato V, Medica P, Liotta L. Adaptive Responses of Thyroid Hormones, Insulin, and Glucose during Pregnancy and Lactation in Dairy Cows. Animals (Basel) 2022 May 28;12(11).
        doi: 10.3390/ani12111395pubmed: 35681859google scholar: lookup
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        doi: 10.1111/brv.12791pubmed: 34476892google scholar: lookup
      5. Thoresen SI, Wergeland R, Mørkrid L, Stokke O. Evaluation of an enzymatic immunoassay for free thyroxine determination in canine serum. Vet Res Commun 1996;20(5):411-20.
        doi: 10.1007/BF00419178pubmed: 8908721google scholar: lookup
      6. Bruschetta G, Bionda A, Giunta RP, Costa GL, Fazio E, Licata P, Bruno F. Can Productive Aptitude and Age Affect Circulating Serotonin, Total Thyroid Hormones, and Cortisol Patterns in Cows?. Vet Sci 2024 Oct 2;11(10).
        doi: 10.3390/vetsci11100471pubmed: 39453063google scholar: lookup
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