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Home / Equine Research Bank / J Anim Sci Technol / Transplantation of spermatogonial stem cells in stallions.
Journal of animal science and technology2024; 66(4); 635-644; doi: 10.5187/jast.2024.e30

Transplantation of spermatogonial stem cells in stallions.

Abstract: Spermatogonial stem cells originate from gonocytes and undergo self-renewal and differentiation to generate mature spermatozoa via spermatogenesis in the seminiferous tubules of the testis in male mammals. Owing to the unique capacity of these cells, the spermatogonial stem cell transplantation technique, which enables the restoration of male fertility by transfer of germlines between donor and recipient males, has been developed. Thus, spermatogonial stem cell transplantation can be used as an important next-generation reproductive and breeding tool in livestock production. However, in large animals, this approach is associated with many technical limitations and inefficiency. Furthermore, research regrading spermatogonial stem cell transplantation in stallions is limited. Therefore, this review article describes the history and current knowledge regarding spermatogonial stem cell transplantation in animals and challenges in establishing an experimental protocol for successful spermatogonial stem cell transplantation in stallions, which have been presented under the following heads: spermatogonial stem cell isolation, recipient preparation, and spermatogonial stem cell transplantation. Additionally, we suggest that further investigation based on previous unequivocal evidence regarding donor-derived spermatogenesis in large animals must be conducted. A detailed and better understanding of the physical and physiological aspects is required to discuss the current status of this technique field and develop future directions for the establishment of spermatogonial stem cell transplantation in stallions.
© Copyright 2024 Korean Society of Animal Science and Technology.
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Publication Date: 2024-07-31 PubMed ID: 39165739PubMed Central: PMC11331362DOI: 10.5187/jast.2024.e30Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article discusses the development and challenges of transplanting spermatogonial stem cells (cells involved in sperm production) in stallions (male horses), a potentially important tool for enhancing livestock production.

Introduction to Spermatogonial Stem Cell Transplantation

  • Spermatogonial stem cells (SSCs), which are responsible for the generation of mature sperm cells in male mammals, are derived from a type of stem cell called gonocytes.
  • SSCs possess certain unique attributes, such as self-renewal (ability to produce copies of themselves) and differentiation (evolution into other types of cells).
  • Through a process known as SSC transplantation, transferring these cells between different males can restore fertility in those who may be infertile.
  • This transplant technique has potential uses in livestock production systems as a next-generation reproductive tool.

Challenges in SSC Transplantation in Large Animals

  • Despite the potential advantages of SSC transplantation, implementing it in larger animals, particularly stallions, has proven challenging due to various technical limitations and issues of inefficiency.
  • The article mentions a lack of detailed research on SSC transplantation in stallions, signaling a need for further study in this area.

Key Aspects of SSC Transplantation

  • The research article highlights three main areas to focus on when performing SSC transplantation: SSC isolation, recipient preparation, and the transplantation itself.
  • The authors stress on the need for an in-depth understanding of the physical and physiological aspects involved in the process for progress in this field.

Conclusion and Future Directions

  • The researchers suggest that more conclusive evidence is needed regarding donor-derived spermatogenesis in large animals.
  • This would entail further investigation and the establishment of clear experimental protocols for SSC transplantation in stallions.
  • Success in these areas could help overcome the current technical challenges and inefficiencies observed in this field, and open up new possibilities for reproductive interventions in livestock production.

Cite This Article

APA
Jung H, Yoon M. (2024). Transplantation of spermatogonial stem cells in stallions. J Anim Sci Technol, 66(4), 635-644. https://doi.org/10.5187/jast.2024.e30

Publication

Journal of animal science and technology
ISSN: 2055-0391
NlmUniqueID: 101661694
Country: Korea (South)
Language: English
Volume: 66
Issue: 4
Pages: 635-644

Researcher Affiliations

Jung, Heejun
  • Research Center for Horse Industry, Kyungpook National University, Sangju 37224, Korea.
Yoon, Minjung
  • Research Center for Horse Industry, Kyungpook National University, Sangju 37224, Korea.
  • Department of Horse, Companion and Wild Animal Science, Kyungpook National University, Sangju 37224, Korea.

Conflict of Interest Statement

No potential conflict of interest relevant to this article was reported.

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