Whole blood glutathione peroxidase activity in Standardbred broodmares supplemented with vitamin E and selenium.
Abstract: The objective of this study was to determine the effect of either oral supplementation of sodium selenite and alpha-tocopherol or intramuscular administration of a commercial preparation of selenium (Se) and vitamin E to Standardbred broodmares with low (21.0 ± 18.1 IU/g Hb) whole blood glutathione peroxidase (GPx) activity. Ten mares received 3 weekly intramuscular (IM) doses, whereas 9 mares were orally supplemented daily for 10 wk. Blood samples were collected jugular venipuncture and the whole blood GPx activity was measured at each sampling time for the 32-week period. Both oral and intramuscular administration resulted in a marked increase in whole blood GPx activity in both groups of mares. L’objectif de cette étude était de déterminer l’effet d’une supplémentation orale en sélénite de sodium et en alpha-tocophérol, ou d’une administration intramusculaire d’une préparation commerciale de sélénium (Se) et de vitamine E, chez des juments poulinières Standardbred présentant une faible activité de glutathion peroxydase (GPx) sanguine (21,0 ± 18,1 UI/g Hb). Dix juments ont reçu 3 injections intramusculaires (IM) hebdomadaires, tandis que 9 autres ont reçu une supplémentation orale quotidienne pendant 10 semaines. Des échantillons de sang ont été prélevés par ponction de la veine jugulaire et l’activité de la GPx sanguine a été mesurée à chaque prélèvement pendant les 32 semaines de l’étude. L’administration orale autant qu’intramusculaire, a entraîné une augmentation significative de l’activité de la GPx sanguine dans les deux groupes de juments.(Traduit par Docteur Serge Messier).
Copyright and/or publishing rights held by the Canadian Veterinary Medical Association.
Publication Date: 2026-01-01 PubMed ID: 41585003PubMed Central: PMC12825818
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- Journal Article
Cite This Article
APA
Baird JD, Arroyo LG, Lumsden JH.
(2026).
Whole blood glutathione peroxidase activity in Standardbred broodmares supplemented with vitamin E and selenium.
Can J Vet Res, 90(1), 25-29.
Publication
Researcher Affiliations
- Department of Clinical Studies (Baird, Arroyo) and Department of Pathobiology (Lumsden), Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1.
- Department of Clinical Studies (Baird, Arroyo) and Department of Pathobiology (Lumsden), Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1.
- Department of Clinical Studies (Baird, Arroyo) and Department of Pathobiology (Lumsden), Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1.
MeSH Terms
- Animals
- Female
- Glutathione Peroxidase / blood
- Glutathione Peroxidase / metabolism
- Glutathione Peroxidase / genetics
- Dietary Supplements
- Selenium / administration & dosage
- Selenium / pharmacology
- Vitamin E / administration & dosage
- Vitamin E / pharmacology
- Horses / blood
- Administration, Oral
- Injections, Intramuscular / veterinary
- Sodium Selenite / administration & dosage
- Sodium Selenite / pharmacology
- Diet / veterinary
- Animal Feed / analysis
- Animal Nutritional Physiological Phenomena
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