Xylazine and tiletamine-zolazepam anesthesia in horses.
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
The study examines the impact of combining xylazine with tiletamine-zolazepam for anesthesia in horses, focusing on cardiopulmonary and anesthetic effects.
Experiment Design and Procedure
The experimental design was such that six horses were administered with a combined anesthetic regimen of xylazine and a 1:1 mixture of tiletamine and zolazepam. These drugs were administered via intravenous (IV) or intramuscular (IM) injections in four different treatments, using a randomized order. The specifics of these treatment options were:
- Treatment 1: 1.1 mg of xylazine/kg body weight (IV) and 1.1 mg of tiletamine-zolazepam/kg (IV)
- Treatment 2: 1.1 mg of xylazine/kg (IV) and 1.65 mg of tiletamine-zolazepam/kg (IV)
- Treatment 3: 1.1 mg of xylazine/kg (IV) and 2.2 mg of tiletamine-zolazepam/kg (IV)
- Treatment 4: 2.2 mg of xylazine/kg (IM) and 1.65 mg of tiletamine-zolazepam/kg (IV)
For the IV implementation, xylazine was administered five minutes before tiletamine-zolazepam, while in the IM method, xylazine was administered ten minutes before.
Outcomes and Observations
Tiletamine-zolazepam consistently induced recumbency (lying down) across all horses. However, duration of recumbency was seen to increase on raising the dosage of tiletamine-zolazepam, evident in the results from treatments 2 and 3.
On administration, Xylazine was observed to significantly lower heart rate and cardiac output. It also significantly elevated central venous pressure and the average pulmonary artery pressure. Reduction in respiratory rate was also exhibited in horses post xylazine administration.
Arterial blood pressure saw a significant surge when xylazine was implemented via IV in treatments 1 and 3, though it wasn’t significant in treatment 2. For the IM process, applying xylazine led to considerable rises in central venous pressure along with notable reductions in cardiac output.
This study, therefore, provides useful insights into the change in cardiopulmonary and anesthetic effects when horses are induced with combined xylazine and tiletamine-zolazepam anesthesia.
Cite This Article
Publication
Researcher Affiliations
- Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus 43210.
MeSH Terms
- Anesthesia, Intravenous / veterinary
- Animals
- Azepines / pharmacology
- Blood Gas Analysis / veterinary
- Blood Pressure / drug effects
- Cyclohexanes / pharmacology
- Drug Combinations
- Heart Rate / drug effects
- Horses / physiology
- Respiration / drug effects
- Thiazines / pharmacology
- Tiletamine / pharmacology
- Time Factors
- Xylazine / pharmacology
- Zolazepam / pharmacology
Citations
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