ACS applied materials & interfaces.
Publisher:
American Chemical Society
Frequency: Monthly
Country: United States
Language: English
Author(s):
American Chemical Society.
Start Year:2009 -
Identifiers
| ISSN: | 1944-8244 (Print) 1944-8252 (Electronic) 1944-8244 (Linking) |
| NLM ID: | 101504991 |
| (OCoLC): | 238703087 |
| LCCN: | 2008201974 |
| Classification: | W1 AC73808 |
H2S Activated Drug Release from Protein Cages. We took advantage of gasotransmitter HS as a chemical reaction-based trigger for controlled release of doxorubicin which is precoordinated by copper ions and enclosed in horse spleen apoferritin. The nanocomposite is stable at physiological pH and temperature before HS activation. The drug release process avoids disassembly of protein shells and is controllable by the strong affinity of sulfide with copper ions. The in vitro cytotoxicity assay indicates the antitumor effect of doxorubicin toward tumor cells could be achievable by HS activation.