Advanced drug delivery reviews.
Publisher:
Elsevier Science Publishers, B.V.,
Frequency: Twelve no. a year, 2001-
Country: Netherlands
Language: English
Start Year:1987 -
ISSN:
0169-409X (Print)
1872-8294 (Electronic)
0169-409X (Linking)
1872-8294 (Electronic)
0169-409X (Linking)
Impact Factor
16.1
2022
| NLM ID: | 8710523 |
| (DNLM): | SR0054804(s) |
| (OCoLC): | 13190647 |
| Coden: | ADDREP |
| LCCN: | sn 87026401 |
| Classification: | W1 AD402C |
Progress in cell-based therapies for tendon repair. The last decade has seen significant developments in cell therapies, based on permanently differentiated, reprogrammed or engineered stem cells, for tendon injuries and degenerative conditions. In vitro studies assess the influence of biophysical, biochemical and biological signals on tenogenic phenotype maintenance and/or differentiation towards tenogenic lineage. However, the ideal culture environment has yet to be identified due to the lack of standardised experimental setup and readout system. Bone marrow mesenchymal stem cells and tenocytes/dermal fibroblasts appear to be the cell populat...
The past, present and future in scaffold-based tendon treatments. Tendon injuries represent a significant clinical burden on healthcare systems worldwide. As the human population ages and the life expectancy increases, tendon injuries will become more prevalent, especially among young individuals with long life ahead of them. Advancements in engineering, chemistry and biology have made available an array of three-dimensional scaffold-based intervention strategies, natural or synthetic in origin. Further, functionalisation strategies, based on biophysical, biochemical and biological cues, offer control over cellular functions; localisation and sustained relea...