Ageing research reviews.
Publisher:
Elsevier Science,
Frequency: Four no. a year
Country: England
Language: English
Start Year:2002 -
ISSN:
1568-1637 (Print)
1872-9649 (Electronic)
1568-1637 (Linking)
1872-9649 (Electronic)
1568-1637 (Linking)
Impact Factor
13.1
2022
| NLM ID: | 101128963 |
| (OCoLC): | 49560020 |
| LCCN: | 2002243184 |
| Classification: | W1 AG326CB |
A review of the equine age-related changes in the immune system: comparisons between human and equine aging, with focus on lung-specific immune-aging. The equine aging process involves many changes to the immune system that may be related to genetics, the level of nutrition, the environment and/or an underlying subclinical disease. Geriatric horses defined as horses above the age of 20, exhibit a decline in body condition, muscle tone and general well-being. It is not known whether these changes contribute to decreased immune function or are the result of declining immune function. Geriatric years are characterized by increased susceptibility to infections and a reduced antibody response to vaccination as a result of changes in the immune sy...
Advantages and limitations of the equine disease, pituitary pars intermedia dysfunction as a model of spontaneous dopaminergic neurodegenerative disease. Parkinson's disease (PD) is a leading cause of neurologic disability in the aged population. Remarkable progress has been made in the past decade to understand the cellular and molecular events that occur in PD. However attempts to unravel the early, initiating factors in the pathogenesis of dopaminergic neurodegeneration and PD have been limited by the lack of a suitable animal model. Models in which there has been genetic or environmental manipulation are not of use in determining the natural cause of a disease. While a large scale prospective human study would be ideal, the relatively low p...