AIDS research and human retroviruses.
Publisher:
Mary Ann Liebert,. Larchmont, NY : Mary Ann Liebert
Frequency: Eighteen no. a year
Country: United States
Language: English
Start Year:1987 -
ISSN:
0889-2229 (Print)
1931-8405 (Electronic)
0889-2229 (Linking)
1931-8405 (Electronic)
0889-2229 (Linking)
Impact Factor
1.5
2022
| NLM ID: | 8709376 |
| (OCoLC): | 13812822 |
| (DNLM): | SR0057967(s) |
| Coden: | ARHRE7 |
| Classification: | W1 A11666 |
A conservative domain shared by HIV gp120 and EIAV gp90: implications for HIV vaccine design. Both HIV and EIAV belong to the retroviridae family and lentivirus genus. Two variable regions (V3 and V4) of equine infectious anemia virus (EIAV) gp90 and two variable regions (V1 and V2) of HIV gp120 possibly adopt the same topology. We have studied the N-glycosylation properties and B cell linear epitope distribution profile of these two regions. Our results indicated that V3 and V4 of EIAV gp90 are very similar to V1 and V2 of HIV gp120. The differences between EIAV virulent and vaccine strains are mainly located at these two regions. Vaccine strains lose two N-glycosylation sites at thes...
High prevalence of serum antibodies to equine infectious anemia virus reverse transcriptase. The immunogenicity of the equine infectious anemia virus (EIAV) reverse transcriptase (RT) was examined by immunoblot assay with recombinant EIAV RT. All of the 19 sera from EIAV-infected horses tested contained antibodies that recognized EIAV RT and directly inhibited the polymerase activity of the enzyme. An examination of sera obtained sequentially from two experimentally infected animals revealed that anti-RT antibodies arise early in infection and increase in level. The appearance of the antibodies correlated with progression toward the asymptomatic period of infection.