American journal of physiology. Endocrinology and metabolism.
Publisher:
American Physiological Society
Frequency: Twice monthly, Feb. 2012-
Country: United States
Language: English
Author(s):
American Physiological Society (1887- )
Start Year:1980 -
ISSN:
0193-1849 (Print)
1522-1555 (Electronic)
0193-1849 (Linking)
1522-1555 (Electronic)
0193-1849 (Linking)
Impact Factor
5.1
2022
| NLM ID: | 100901226 |
| (OCoLC): | 05160965 |
| LCCN: | 80645400 |
| Classification: | W1 AM507E |
Equine hyperinsulinemia: investigation of the enteroinsular axis during insulin dysregulation. Compared with some other species, insulin dysregulation in equids is poorly understood. However, hyperinsulinemia causes laminitis, a significant and often lethal disease affecting the pedal bone/hoof wall attachment site. Until recently, hyperinsulinemia has been considered a counterregulatory response to insulin resistance (IR), but there is growing evidence to support a gastrointestinal etiology. Incretin hormones released from the proximal intestine, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide, augment insulin secretion in several species but require invest...
Stimulation by iodide of H(2)O(2) generation in thyroid slices from several species. The regulation of thyroid metabolism by iodide involves numerous inhibitory effects. However, in unstimulated dog thyroid slices, a small inconstant stimulatory effect of iodide on H(2)O(2) generation is observed. The only other stimulatory effect reported with iodide is on [1-(14)C]glucose oxidation, i.e., on the pentose phosphate pathway. Because we have recently demonstrated that the pentose phosphate pathway is controlled by H(2)O(2) generation, we study here the effect of iodide on basal H(2)O(2) generation in thyroid slices from several species. Our data show that in sheep, pig, bovine, ...