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The American journal of surgical pathology.
Publisher:
Masson.. Philadelphia, PA : Wolters Kluwer Health, Inc. (2015)
Frequency: Monthly (with special supplement in Mar.),
Country: United States
Language: English
Start Year:1977 -
Identifiers
| ISSN: | 0147-5185 (Print) 1532-0979 (Electronic) 0147-5185 (Linking) |
| NLM ID: | 7707904 |
| (DNLM): | A25005000(s) |
| (OCoLC): | 03181447 |
| Coden: | AJSPDX |
| Classification: | W1 AM523BJ |
Loss of expression of protein kinase a regulatory subunit 1alpha in pigmented epithelioid melanocytoma but not in melanoma or other melanocytic lesions. Pigmented epithelioid melanocytoma (PEM) is a recently described entity comprising most cases previously described as "animal-type melanoma" and epithelioid blue nevus (EBN) occurring in patients with the multiple neoplasia syndrome Carney complex (CNC). Mutations of the protein kinase A regulatory subunit type 1alpha (R1alpha) (coded by the PRKAR1A gene) are found in more than half of CNC patients. In this study, we investigated whether PEM and EBN are related at the molecular level, and whether changes in the PRKAR1A gene status and the expression of the R1alpha protein may be involved in th...
